Association between single nucleotide polymorphisms of <i>VEGF</i> gene and pelvic lymph node metastasis in patients with early-stage cervical cancer

Zhong, Wei; Guo, Xingyan; He, Yan; Yasen, Maimaiti; Adilai, Maimaitimin; Abudubari, Hailiqiemu; Abudukadier, Abuduhelili; Xiafukaiti, Alifu

doi:10.1080/01443615.2021.1963691

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…As reported by recent studies VEGF-460 C/T polymorphism were CC genotype and C allele were significantly associated with increased risk of esophageal cancer (Guleria et al, 2022). VEGF polymorphisms have previously been described in solid carcinoma ,containing lung cancer (F. Yang et al, 2018) cervical cancer (W. Zhong et al, 2022) colorectal cancer (Kontham et al, 2022) and renal cell carcinoma ,results showed dramatically high risk for renal cell carcinoma were found regarding most genetic models and alleles of the +936 C/T polymorphism ,in addition significant increased risk with -2578 C/A .However ,no significant association were found between renal cell carcinoma risk and the -460C/T polymorphism (Gong et al, 2017) Han et al, (2015 they observed CC genotype was risk for coronary heart diseases (OR=2.5, 95%CI =1.1-5.68) and the frequencies of -460 C/T CC genotype (13.6%) was found higher in the case group than that of control group (6.7%). In this study elevated serum level of VEGF were associated with the -460 C/C, -2578 C/C and +936 C/C.…”

Section: Discussionmentioning

confidence: 88%

Untitled

2023

ecb

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Background: A vital role of vascular Endothelial Growth Factor was angiogenesis in kidney, that one of the most heavily vascularized organs. the current study aimed to analyze the genotype frequency of VEGF gene polymorphism (-460, -2578 and +936) between 104 hypothyroidism patients at the dialysis unit in Basrah Hospitals and 60 healthy controls, also studied effect on serum level VEGF-A. Methods: Amplification Refractory Mutation System Real-Time PCR (ARMS RT-PCR) was used to identify the VEGF -460 C/T, -2578C/A, and +936 C/T single nucleotide polymorphisms (SNP) in all included patients. Results: In comparison to the patient group, the control group had a larger distribution of the VEGF-460 C/T genotype .The CC genotype of -460 SNP showed a higher frequency with the hypothyroidism patients on hemodialysis. For VEGF -2578 C/A, VEGF + 936 C/T, for cases and healthy control persons, we did not find any differences in genotypes that were statistically significant (p=0.7 and p=0.5, respectively). The dominant model showed a significant association with the protective effect of subclinical hypothyroidism .However ,no significant association was observed between this polymorphism and subclinical hypothyroidism susceptibility in recessive model and allele frequency for -460 C/T. There was no association between -460 rs 833061 polymorphism with overt hypothyroidism in all genetic models .There was no association between VEGF-2578 C/A and +936 C/T polymorphism with hypothyroidism (subclinical ,overt) in all genetic models .VEGF levels in serum from patients were significantly higher than those in healthy subjects . Conclusion:The VEGF gene is highly polymorphic, and some variations may be connected to ESRD in hypothyroid patients. The pathophysiology of chronic kidney failure may be significantly influenced by VEGF polymorphisms, Our findings indicated that VEGF polymorphisms decreased the risk of hypothyroidism. Since this the first study ,further studies with different races are required to confirm our results.

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Section: Discussionmentioning

confidence: 88%

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2023

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“…It is currently divided into squamous cell cervical cancer, which occurs in 85–90% of all cervical cancers; adenocarcinoma, which occurs in 10–15% of all cervical cancers; and other epithelial tumors [ 7 , 8 ]. The prognostic significance of VEGF-A (Vascular Endothelial Growth Factor-A) in cervical cancer is still a matter of scientific interest [ 9 ]. Angiogenesis is considered an important biological process for the growth of primary cancer as well as metastases [ 10 ], and according to the literature, VEGF-A is a significant biomarker that enhances tumor angiogenesis [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Expression of Vascular Endothelial Growth Factor-A (VEGF-A) in Adenocarcinoma and Squamous Cell Cervical Cancer and Its Impact on Disease Progression: Single Institution Experience

Piškur,

Topolovec,

Bakula

et al. 2023

Medicina

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Background and Objectives: The aim of this retrospective study was to determine the difference in VEGF-A expression in adenocarcinoma and squamous cell cervical cancer and to show the influence of VEGF-A expression on clinical, pathological, and therapeutic prognostic factors on the outcome of treatment and the survival of patients. Materials and Methods: The study included patients with cervical cancer who were treated in the period from 1 January 2010 to 31 December 2021 at the Clinic for Gynecology and Obstetrics, University Hospital Centre, Osijek. The researchers conducted a retrospective analysis of data from patients’ medical history, along with the pathohistological findings and oncologist findings. The study included 66 patients with cervical cancer (divided into two subgroups of 33 with adenocarcinoma or squamous cell cervical cancer). Diagnosis was based on the pathohistological status and FIGO staging. VEGF-A expression was significantly higher in adenocarcinoma. Subjects with a higher expression of VEGF-A had a significantly higher rate of disease progression and a higher possibility for lethal outcome. Results: Statistically significant prognostic factors in bivariate analysis in predicting a negative treatment outcome were: older age, greater depth of stromal invasion, FIGO IIB stage, chemotherapy, and positive lymph nodes. In the multivariate analysis, age and positive lymph nodes were shown to be significant predictors for a negative treatment outcome. Conclusions: VEGF-A has shown to be statistically more expressed in adenocarcinoma, which correlates with disease progression, but not statistically significant in multivariate regression analysis as an independent prognostic factor for poor survival of the subjects.

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Association of <i>VEGFA</i> gene rs2010963 polymorphism with cervical cancer and its progression

Rogalev,

Kishenya,

Pishchulina

et al. 2023

Almanac of Clinical Medicine

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Background: Cervical cancer is the most common type of female genital malignancies. In Russia, its incidence is 17 to 19 cases per 100,000 of female population. Cervical cancer is characterized by high activity, rapid development of radio/chemoresistance and unfavorable prognosis. To assess the risk of recurrence, metastasis and choice of the optimal treatment strategy, factors related to the disease progression are under study. Vascular endothelial growth factor (VEGF) overexpression is related to tumor angiogenesis and poor outcome in various cancer types, including cervical cancer. Aim: To study an association between the rs2010963 polymorphism of the VEGFA gene and risk of development and progression of cervical cancer. Materials and methods: This case-control study included 120 women (aged 49 [42; 65] years) with cervical cancer stage I-II and 112 women without cervical or other types of cancer. Based on the results of histological examination, two subgroups were formed: the one with tumor emboli (TE+) in the tumor vasculature and surrounding tissues (n = 41, 34.17%) and the other without tumor emboli (TE-) (n = 79, 65.83%). The polymorphic DNA loci of the rs2010963 VEGFA gene were analyzed by real time polymerase chain reaction. Results: In the patients, cervical cancer has associated with the VEGFA gene allelic polymorphism rs2010963 (χ2 = 5.47; p = 0.021). The minor C allele increased risk of cervical cancer by 1.6-fold (odds ratio (ОR) 1.58, 95% confidence interval (CI) 1.08-2.31), and the ancestral G allele reduced the cervical cancer probability (ОR 0.63, 95% CI 0.43-0.93). The genotypes distribution in the dominant model (GG and GC + CC) confirmed the association of the rs2010963 VEGFA gene polymorphism with cervical cancer (χ2 = 4.73; p = 0.031), specifically, if there was a minor C allele in the genotype (GC + CC). We found that the association of the rs2010963 VEGFA gene polymorphism with TE in the tumor vessels and surrounding tissues was a predictor of unfavorable progression and metastasis of cervical cancer (χ2 = 3.94; р = 0.049). The minor C allele increased the risk of TE by 1.7-fold (ОR 1.72, 95% CI 1.004-2.98), whereas the ancestral G allele reduced this chance (ОR 0.58, 95% CI 0.34-0.996). Conclusion: The C allele of the rs2010963 polymorphism of the VEGFA gene is a risk factor for cervical cancer, as well as a risk factor for the development of tumor emboli.

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Association between single nucleotide polymorphisms of VEGF gene and pelvic lymph node metastasis in patients with early-stage cervical cancer

Cited by 3 publications

References 21 publications

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Expression of Vascular Endothelial Growth Factor-A (VEGF-A) in Adenocarcinoma and Squamous Cell Cervical Cancer and Its Impact on Disease Progression: Single Institution Experience

Association of <i>VEGFA</i> gene rs2010963 polymorphism with cervical cancer and its progression

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