Association between Single Nucleotide Polymorphisms in the OPRM1 Gene and Intraoperative Remifentanil Consumption in Northern Chinese Women

Liu, Jing; Hu, Dongxue; Jiang, Yongdong; Xi, Hongjie; Li, Wenzhi

doi:10.1159/000368082

Cited by 7 publications

(13 citation statements)

References 25 publications

(25 reference statements)

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“…Chau et al, 16 found that patients with AA genotype required less postoperative morphine dose than patients with genotype AG or AA. Also, Liu et al, 6 found that patients carrying one or 2 copies of the minor allele (G allele) required significantly more intraoperative remifentanil than in patients without the minor allele ( p =0.001). We performed our study on Jordanian patients (Arab ethnic group) and our findings coincide with Liu et al, 6 where the remifentanil consumed in the intra-operative time to maintain a SBP between 90-100 mm Hg was higher in AG gene compared with AA gene.…”

Section: Discussionmentioning

confidence: 98%

“…Also, Liu et al, 6 found that patients carrying one or 2 copies of the minor allele (G allele) required significantly more intraoperative remifentanil than in patients without the minor allele ( p =0.001). We performed our study on Jordanian patients (Arab ethnic group) and our findings coincide with Liu et al, 6 where the remifentanil consumed in the intra-operative time to maintain a SBP between 90-100 mm Hg was higher in AG gene compared with AA gene. The mean required dose of remifentanil for patients with AG gene was 0.316 µg kg -1 min -1 , and for the patients with AA gene it was 0.173 µg kg -1 min -1 ( p <0.0001).…”

Section: Discussionmentioning

confidence: 98%

“… 9 To avoid the effect of those factors we designed our study to calculate the amount of narcotic used in the intra-operative time for patients who underwent septoplasty surgery under general anesthesia. The Liu et al 6 study was the only study done in the intraoperative time and they used remifentanil as a narcotics agent. In this study, anesthesia was performed under MAC and maintained by the intravenous infusion of remifentanil during hysteroscopy surgery.…”

Section: Discussionmentioning

confidence: 99%

“…In their study they assessed the intra-operative pain using the visual analogue score (VAS), gave fixed weight adjusted dose (µg kg -1 min -1 ), and gave a bolus dose of 0.25 µg kg -1 to keep VAS below 3. Our study was build on the Liu et al 6 study, and the main difference was that our study was conducted under complete general anesthesia and the only factor that decided the dose of remifentanil was the value of SBP affected by severity of pain that comes from surgical stimulation. Sympathetic stimulation caused by painful surgical stimuli leads to increase secretion of catecholamines from the adrenal medulla and release of norepinephrine from presynaptic nerve terminals.…”

Section: Discussionmentioning

confidence: 99%

“…The meta-analysis provided evidence that there is variation in the amount of opioid consumed in the postoperative period in correlation with OPRM1 A118G polymorphism and this variation depends on the type of opioid used, type of surgery, and the difference in ethnic group. In one study conducted on Chinese women, 6 researchers assessed the association between SNPs in the OPRM1 gene and intraoperative remifentanil consumption in patients who had surgery under monitored anesthesia care (MAC). From our observation, we thought that there is variation in the amount of Remifentanil consumed intra-operatively in Jordanian patients, and this difference came from gene variance.…”

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confidence: 99%

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Remifentanil consumption in septoplasty surgery under general anesthesia

Almustafa

Oweidi

Al-Zaben

et al. 2017

SMJ

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Objectives:To evaluate the influence of the ORM1 variants in codon 118 on the intra-operative remifentanil consumption under general anesthesia.Methods:A prospective gene association study, performed at the Jordan University Jordan, Amman, Jordan from September 2013 to August 2014. It includes patients who underwent septoplasty surgery under general anesthesia. All patients received standard intravenous anesthesia. Anesthesia maintained with fixed dose of Sevoflurane and variable dose of Remifentanil to keep the systolic blood pressure between 90-100 mm Hg. The Remifentanil dose was calculated and correlated with ORM1 genotype variance.Results:Genotype and clinical data were available for 123 cases. The A118A genotype was seen in 96 patients (78%), the A118G genotype was seen in 25 patients (20.3%), and only 2 patients had genotype G118G (1.6%). The G118G variant was removed from the statistical analysis due to small sample size. There was a significant effect of ORM1 genotype variant and the amount of remifentanil consumed. The A118A genotype received 0.173 ± 0.063 µg kg-1 min-1 and the A118G genotype received 0.316 ± 0.100 µg kg-1 min-1 (p<0.0001).Conclusion:The ORM1 gene has a role in intra-operative remifentanil consumption in patients who underwent septoplasty surgery under general anesthesia. The A118G gene required higher dose of remifentanil compared with the A118A genotype.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Remifentanil consumption in septoplasty surgery under general anesthesia

Almustafa

Oweidi

Al-Zaben

et al. 2017

SMJ

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Effect of A118G (rs1799971) single‐nucleotide polymorphism of the μ‐opioid receptor OPRM1 gene on intraoperative remifentanil requirements in Japanese women undergoing laparoscopic gynecological surgery

Zou,

Nishizawa,

Inoue

et al. 2024

Neuropsychopharm Rep

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AimAbundant data are available on the effect of the A118G (rs1799971) single‐nucleotide polymorphism (SNP) of the μ‐opioid receptor OPRM1 gene on morphine and fentanyl requirements for pain control. However, data on the effect of this SNP on intraoperative remifentanil requirements remain limited. We investigated the effect of this SNP on intraoperative remifentanil requirements.MethodsWe investigated 333 Japanese women, aged 21–69 years, who underwent laparoscopic gynecological surgery for benign gynecological disease under total intravenous anesthesia at Juntendo University Hospital. Average infusion rates of propofol and remifentanil during anesthesia and the average bispectral index (BIS) during surgery were recorded. Associations among genotypes of the A118G and phenotypes were examined with the Mann–Whitney U test.ResultsThe average propofol infusion rate was not different between patients with different genotypes. The average remifentanil infusion rate was significantly higher in patients with the AG or GG genotype than the AA genotype (p = 0.028). The average intraoperative BIS was significantly higher in patients with the GG genotype than the AA or AG genotype (p = 0.039).ConclusionsThe G allele of the A118G SNP was associated with higher intraoperative remifentanil requirements and higher intraoperative BIS values but was not associated with propofol requirements. Given that remifentanil and propofol act synergistically on the BIS, these results suggest that the G allele of the A118G SNP is associated with lower effects of remifentanil in achieving adequate intraoperative analgesia and in potentiating the sedative effect of propofol on the BIS.

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Progress, Challenges, and Prospects of Research on the Effect of Gene Polymorphisms on Adverse Reactions to Opioids

et al. 2022

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The abuse of opioids has become one of the most serious concerns in the world. Opioid use can cause serious adverse reactions, including respiratory depression, postoperative nausea and vomiting, itching, and even death. These adverse reactions are also important complications of clinical application of opioid drugs that may affect patient safety and recovery. Due to the fear of adverse reactions of opioids, clinicians often do not dare to use opioids in an adequate or appropriate amount, thus affecting the clinical medication strategy and the quality of treatment for patients. The prediction of

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Association between Single Nucleotide Polymorphisms in the OPRM1 Gene and Intraoperative Remifentanil Consumption in Northern Chinese Women

Abstract: SNP rs558025 in the OPRM1 gene was associated with intraoperative remifentanil consumption during gynecological hysteroscopic surgery in our subjects.

Cited by 7 publications

References 25 publications

Remifentanil consumption in septoplasty surgery under general anesthesia

Remifentanil consumption in septoplasty surgery under general anesthesia

Effect of A118G (rs1799971) single‐nucleotide polymorphism of the μ‐opioid receptor OPRM1 gene on intraoperative remifentanil requirements in Japanese women undergoing laparoscopic gynecological surgery

Progress, Challenges, and Prospects of Research on the Effect of Gene Polymorphisms on Adverse Reactions to Opioids

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