Association between single nucleotide polymorphisms in the XRCC1 and RAD51 genes and clinical radiosensitivity in head and neck cancer

Pratesi, Nicola; Mangoni, Monica; Mancini, Irene; Paiar, Fabiola; Simi, Lisa; Livi, Lorenzo; Cassani, S.; Buglione, Michela; Grisanti, Salvatore; Almici, Camillo; Polli, Caterina; Saieva, Calogero; Magrini, Stefano Maria; Biti, Giampaolo; Pazzagli, Mario; Orlando, Claudio

doi:10.1016/j.radonc.2011.05.062

Cited by 85 publications

(61 citation statements)

References 37 publications

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“…However, the genotype distribution of TGFb1 T869C was significantly different from that in Chinese normal population (P , 0.001). The genotype distribution of TGFb1, XRCC3 and ATM frequencies of XRCC3 722C.T (0.09 in (24)(25)(26). Such a phenomenon may be resulted from racial difference.…”

Section: Discussionmentioning

confidence: 98%

XRCC3 Polymorphisms are Associated with the Risk of Developing Radiation-induced Late Xerostomia in Nasopharyngeal Carcinoma Patients Treated with Intensity Modulation Radiated Therapy

Zou¹,

Song²,

Wang³

et al. 2014

Japanese Journal of Clinical Oncology

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Objective: The incidence of radiation-induced late xerostomia varies greatly in nasopharyngeal carcinoma patients treated with radiotherapy. The single-nucleotide polymorphisms in genes involved in DNA repair and fibroblast proliferation may be correlated with such variability. The purpose of this paper was to evaluate the association between the risk of developing radiationinduced late xerostomia and four genetic polymorphisms: TGFb1 C-509T, TGFb1 T869C, XRCC3 722C.T and ATM 5557G.A in nasopharyngeal carcinoma patients treated with Intensity Modulation Radiated Therapy. Methods: The severity of late xerostomia was assessed using a patient self-reported validated xerostomia questionnaire. Polymerase chain reaction-ligation detection reaction methods were performed to determine individual genetic polymorphism. The development of radiationinduced xerostomia associated with genetic polymorphisms was modeled using Cox proportional hazards, accounting for equivalent uniform dose. Results: A total of 43 (41.7%) patients experienced radiation-induced late xerostomia. Univariate Cox proportional hazard analyses showed a higher risk of late xerostomia for patients with XRCC3 722 TT/CT alleles. In multivariate analysis adjusted for clinical and dosimetric factors, XRCC3 722C.T polymorphisms remained a significant factor for higher risk of late xerostomia. Conclusions: To our knowledge, this is the first study that demonstrated an association between genetic polymorphisms and the risk of radiation-induced late xerostomia in nasopharyngeal carcinoma patients treated with Intensity Modulation Radiated Therapy. Our findings suggest that the polymorphisms in XRCC3 are significantly associated with the risk of developing radiation-induced late xerostomia.

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Section: Discussionmentioning

confidence: 98%

XRCC3 Polymorphisms are Associated with the Risk of Developing Radiation-induced Late Xerostomia in Nasopharyngeal Carcinoma Patients Treated with Intensity Modulation Radiated Therapy

Zou¹,

Song²,

Wang³

et al. 2014

Japanese Journal of Clinical Oncology

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“…Radiation-induced pulmonary side effects remain a significant clinical concern [2][3][4], thus research to reveal assays predictive of response to radiotherapy remains at the forefront of molecular radiation oncology [28][29][30]. Recent evidence indicates that interpatient variation in the development of side effects after cancer radiotherapy can not be explained, to a clinically relevant effect, by polymorphisms in individual candidate genes [31], therefore alternative approaches to investigating the genetic basis of radiotherapy side effects are needed [32].…”

Section: Discussionmentioning

confidence: 99%

Genomic and genome-wide association of susceptibility to radiation-induced fibrotic lung disease in mice

Paun¹,

Haston

2012

Radiotherapy and Oncology

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“…SNP-based toxicity risk has been studied using both candidate gene and genome-wide association approaches [95,96]. To date, the use of SNPs as mucositis risk predictors has been evaluated in a relatively small number of studies [95,[97][98][99][100][101].…”

Section: Advances In Mucosal Injury Risk Predictionmentioning

confidence: 99%

Emerging evidence on the pathobiology of mucositis

Al‐Dasooqi

Sonis

Bowen

et al. 2013

Support Care Cancer

168

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Background Considerable progress has been made in our understanding of the biological basis for cancer therapyinduced mucosal barrier injury (mucositis). The last formal review of the subject by MASCC/ISOO was published in 2007; consequently, an update is timely. Methods Panel members reviewed the biomedical literature on mucositis pathobiology published between January 2005 and December 2011.Results Recent research has provided data on the contribution of tissue structure changes, inflammation and microbiome changes to the development of mucositis. Additional research has focused on targeted therapyinduced toxicity, toxicity clustering and the investigation of genetic polymorphisms in toxicity prediction. This review paper summarizes the recent evidence on these aspects of mucositis pathobiology. Conclusion The ultimate goal of mucositis researchers is to identify the most appropriate targets for therapeutic interventions and to be able to predict toxicity risk and personalize interventions to genetically suitable patients. Continuing research efforts are needed to further our understanding of mucositis pathobiology and the pharmacogenomics of toxicity.

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Association between single nucleotide polymorphisms in the XRCC1 and RAD51 genes and clinical radiosensitivity in head and neck cancer

Cited by 85 publications

References 37 publications

XRCC3 Polymorphisms are Associated with the Risk of Developing Radiation-induced Late Xerostomia in Nasopharyngeal Carcinoma Patients Treated with Intensity Modulation Radiated Therapy

XRCC3 Polymorphisms are Associated with the Risk of Developing Radiation-induced Late Xerostomia in Nasopharyngeal Carcinoma Patients Treated with Intensity Modulation Radiated Therapy

Genomic and genome-wide association of susceptibility to radiation-induced fibrotic lung disease in mice

Emerging evidence on the pathobiology of mucositis

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