Association between Single Nucleotide Polymorphisms in the Dgat2 Gene and Beef Carcass and Quality Traits in Commercial Feedlot Steers

Abstract

Diacylglycerol acyltransferase (DGAT) is a key enzyme that catalyzes the final and rate-limiting step of triglyceride synthesis. Both DGAT1 and DGAT2 genes code proteins with DGAT activity. Studies have shown DGAT1 polymorphisms associate with intramuscular fat deposition in beef cattle, but fewer associations between DGAT2 and beef cattle economic traits have been reported. The objective of this study was to investigate single nucleotide polymorphism (SNP) in intron3 of bovine DGAT2 and evaluate the associations of that with carcass, meat quality, and fat yield traits. Test animals were 157 commercial feedlot steers belonging to 3 Chinese native breeds (22 for Luxi, 24 for Jinnan, and 23 for Qinchuan), 3 cross populations (20 for Charolais×Fuzhou, 18 for Limousin ×Luxi, and 17 for Simmental×Jinan) and 1 Taurus pure breed population (16 Angus steers). In the current study, 15 SNP were discovered

Tissue Expression and Variation of the DGAT2 Gene and Its Effect on Carcass and Meat Quality Traits in Yak

“…The association between variation in DGAT2 and the various quantitative traits related to TG synthesis and storage has been recently reported in a number of other animal species. Li et al [11] found that SNPs in intron 3 of DGAT2 were associated with the body weight and fat yield in commercial feedlot steers. Yin et al [15] and Li et al [16] reported that a SNP and 13 bp indel in the 3′-UTR of DGAT2 were associated with backfat thickness and lean percentage in pigs.…”

“…The bovine DGAT2 maps to chromosome 15q25–q26 [10] and numerous variations have been detected in cattle [10,11,12]. The expression of DGAT2 is positively correlated to intramuscular fat (IMF) content in longissimus dorsi muscles of Korean steers [13] and pigs [14].…”

“…The expression of DGAT2 is positively correlated to intramuscular fat (IMF) content in longissimus dorsi muscles of Korean steers [13] and pigs [14]. Variation in DGAT2 has been reported to affect carcass muscle and milk quality traits in various animals, such as fat yield and retail cut weight percentage in commercial feedlot steers [11], backfat thickness and lean percentage in pigs [15,16], milk yield and fat percentage in goats [17], and carcass weight, shear force, and IMF in domestic pigeons [18].…”

Identification, molecular characteristics, and tissue differential expression of <i>DGAT2</i> full-CDS cDNA sequence in Binglangjiang buffalo (<i>Bubalus bubalis</i>)

“…Bovine DGAT2 has been mapped to BTA15q25-26 by fluorescence in situ hybridization (FISH) (Winter et al, 2003). Studies have shown that the polymorphisms of DGAT2 gene were associated with economic traits in some domestic animals, such as carcass, meat quality, and fat yield traits in commercial feedlot steers (Li et al, 2009); back-fat thickness in pigs (Yin et al, 2012); carcass weight and shear force in domestic pigeons (Mao et al, 2018); body weight and length in cattle (Zhang et al, 2007;Mao et al, 2008); and milk yield and fat percentage in goats (An et al, 2011).…”

Transcriptome profiles of whole blood in Italian Holstein and Italian Simmental lactating cows diverging for genetic merit for milk protein

“…These findings suggest that the DGAT1 and DGAT2 play fundamentally different roles in mammalian TAG metabolism (Stone et al, 2004). The DGAT2-specific functions are still poorly understood in livestock, but some recent evidence associated it with carcass fat in commercial feedlot steers (Li et al, 2009) and more recently a genome-wide association study on IH have indicated a marker of milk protein percentage close to the DGAT2 gene (Capomaccio et al, 2015).…”