Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial

Abstract

) and rs2064501 (IL22RA2; P=4.81¥10 -5 ) which map to B-cell genes. ConclusionsOur findings provide evidence that genetic variation is a determinant of progression-free survival of patients with chronic lymphocytic leukemia.

Functional Genetic Polymorphisms in PP2A Subunit Genes Confer Increased Risks of Lung Cancer in Southern and Eastern Chinese

“…Several SNPs in PPP2R1A were reported to associated with various cancer risk including breast cancer [22] and uterine serous carcinoma [41]. Similarly, PPP2R5E SNPs are susceptible loci for risk of breast cancer [47], lymphocytic leukemia [48], and soft tissue sarcoma [49]. However, these SNPs are all located in introns.…”

Chronic lymphocytic leukemia - genomics lead the way

“…6 In the study by Wade et al, the variation at the single nucleotide polymorphism rs2255235 in the B2M gene did not, however, correlate with the levels of serum b2 microglobulin. 10 The significance of this single nucleotide polymorphism does, therefore, remain to be investigated further, especially with regard to a potential prognostic benefit of b2 microglobulin serum levels. In addition, the correlation of a single nucleotide polymorphism (rs11158493) in the PPP2R5E gene is of interest.…”

“…In addition, the correlation of a single nucleotide polymorphism (rs11158493) in the PPP2R5E gene is of interest. 10 Recently, a PPP2R5E interacting partner and a member of the same gene family, PPP2R1B, were reported to be localized in 11q22-q23, a critical recurrently deleted region in CLL. A second tumor suppressor in this region, besides ATM, has been postulated.…”

“…However, although the findings of Wade et al are very interesting, it must be noted that none of the associations was statistically significant in an independent series of 380 cases of CLL. 10 Thus, all prognostic and predictive effects associated with single nucleotide polymorphisms identified based on linkage analyses should be cautiously interpreted and warrant further validation in independent data sets prior to clinical use.…”

“…They correlated the single nucleotide polymorphism variants with the response to first-line chemotherapy with fludarabine, chlorambucil or a combination of fludarabine plus cyclophosphamide. 10 Interestingly, one of the single nucleotide polymorphisms (rs2255235) that could be associated with progression-free survival is localized at the 5é nd of b2 microglobulin (B2M), a part of the major histocompatibility complex. The serum levels of b2 microglobulin protein correlate with the tumor burden and b2 microglobulin is, therefore, a prognostic marker in CLL, with high levels of b2 microglobulin correlating with a …”