Association between shift work and hyperhomocysteinemia in male workers

Abstract

BackgroundShift work is associated with a higher risk of cardiovascular diseases. Here, we sought to assess the relationship between shift work and plasma homocysteine levels. Determining the correlations between shift work and homocysteine levels may provide a better understanding of the mechanisms underlying cardiovascular diseases.MethodsThis study was performed using data from routine health examinations of steel workers in 2017. In total, 431 male workers (70 daytime workers and 361 shift workers) employed on a rolling departure schedule were recruited. Plasma homocysteine levels > 15 μmol/L were considered elevated. The χ2, analysis of variance, and multiple logistic regression analyses were used to examine the association between shift work and plasma homocysteine levels.ResultsIn comparison to daytime workers, the odds ratio (OR) of hyperhomocysteinemia in individuals with < 10 years of shift work was 1.14 (95% confidence interval [CI]: 0.64–2.03), compared to 2.01 (95% CI: 1.14–3.54) for workers with ≥ 10 years of experience. After adjusting for confounding variables, the adjusted OR for shift workers with < 10 years of experience was 0.95 (95% CI: 0.50–1.80), compared to 2.00 (95% CI: 1.07–3.74) for workers with ≥ 10 years of experience.ConclusionsThe risk of hyperhomocysteinemia was significantly higher in shift workers compared to those working normal daytime hours, particularly among long-term shift workers.

Association between shift work and serum homocysteine level in female electronic manufacturing services workers

“…Among the previous studies reporting similar results are the aforementioned study by Kang et al 11 as well as others on the correlation between shift work and the serum homocysteine level. In Martins et al, 27 a study conducted on 30 Brazilian shift work bus drivers and 22 control subjects, the serum homocysteine level was significantly higher in shift workers than in the control (18.57 vs. 9.43 μmol).…”

“…Of note is that the serum homocysteine level could be higher in shift workers than in non-shift workers as shift workers are more susceptible to CVD. In Kang et al, 11 a study on the workers at a steel manufacturing company in South Korea, the serum homocysteine level was shown to be significantly higher in male shift workers with a certain length of work than in male day workers. However, no study has yet reported on the correlation between serum homocysteine level and CVD risk of female workers in South Korea.…”

Consequences of Shift Work and Night Work: A Literature Review

“…The second most referenced subcategory was lifestyles (n = 19), where eating habits stood out [58][59][60][61][62][63][64][65][66], followed by physical exercise [66][67][68], alcoholism [67,69], smoking [67,68], and health behaviors [71,72]. The cardiovascular system references (n = 17) were divided into cardio-metabolic risk factors [65,[73][74][75][76][77][78][79][80][81][82], hypertension [81,[83][84][85], and heart rate [34,86]. The subcategory related to mental health included 16 references, highlighting the study of aspects such as anxiety and depression [37, 50,55,87,88] and burnout [41,84,89].…”