Association Between Severe Acute Contact Dermatitis Due toNigella sativaOil and Epidermal Apoptosis

Abstract

Severe acute contact dermatitis (ACD) to Nigella sativa oil (NSO) after topical use is misdiagnosed. Histological findings are poorly described.Findings: We describe 6 patients who displayed clinical and histopathological features of epidermal necrolysis after NSO skin application. Analysis of the NSO showed thymoquinone and p-cymene as major components.2 Meaning: Acute epidermal apoptotic necrolysis may be triggered by topical agents such as NSO.

A review of Nigella sativa plant‐based therapy in dermatology

“…The use of N. sativa as an affordable and efficacious therapy in dermatology is promising, given the rarity of adverse events and diverse formulations. Yet, three women (aged 20‐47 years) reported fever and acute contact dermatitis (ACD) upon topical N. sativa oil use 44 . Assessment of their skin lesions showed erythematous blisters and pustules covering 30‐40% of their body surface with a positive Nikolsky sign similar to Stevens‐Johnson syndrome or toxic epidermal necrolysis.…”

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome after topical use of Nigella sativa (black cumin) oil

“…3 Few case reports of contact dermatitis, [4][5][6] bullous delayed hypersensitivity and Stevens-Johnson syndrome or toxic epidermal necrosis related to NSO have been published. 7,8 To date, only one case of drug reaction with eosinophilia and systemic symptoms (DRESS), a delayed T-cell adverse drug reaction, after application of NSO has been reported. 9 We report here a case of DRESS after application of NSO confirmed by positive patch test.…”

“…NSO is the subject of studies for its pharmacological properties in various fields such as oncology 2 and allergology 3 . Few case reports of contact dermatitis, 4‐6 bullous delayed hypersensitivity and Stevens–Johnson syndrome or toxic epidermal necrosis related to NSO have been published 7,8 . To date, only one case of drug reaction with eosinophilia and systemic symptoms (DRESS), a delayed T‐cell adverse drug reaction, after application of NSO has been reported 9 .…”

Allergic Contact Dermatitis Induced by Prostaquinon

“…Although the specific causative substance of allergic reaction remain unidentified, some authors [8,9] strongly suggest that TQ may be one of the main allergens involved in the phatophysiologic of contact dermatitis to NS oil.…”