Association between serum vitamin D level and uterine fibroid in premenopausal women in Indian population

Abstract

Serum 25-hydroxyvitamin D 3 levels, uterine leiomyomas, pelvic imagingWe aim to evaluate the association between serum 25-hydroxyvitamin D 3 levels and total number, volume and location of uterine fibroids (UFs) in premenopausal women in North Indian population. This case control study was undertaken in 310 women between 18 years and 45 years of age. Cases comprised of 102 women with fibroid lesion and the control group included 208 women with normal uterine morphology on ultrasonography. Blood samples were taken for measuring 25-hydroxyvitamin D 3 levels. The mean serum 25-hydroxyvitamin D 3 level in the study and control group was 14.52 ± 7.89 ng/mL and 26.6 ± 14.36 ng/mL respectively (p < 0.05). There was significant inverse correlation between serum 25-hydroxyvitamin D 3 levels and total volume of fibroids (p = 0.000) while none between 25-hydroxyvitamin D 3 levels with location, number of fibroids. 25-hydroxyvitamin D 3 deficiency was more common in the study group (54.90%) compared to healthy controls (6.7%) while sufficiency was more common among controls (67.8% vs. 27.45) (p < 0.05). Women with deficient 25-hydroxyvitamin D 3 levels have an odds of 18.36 for developing uterine fibroid. Women with low parity, those belonging to higher socioeconomic status and having less than 1-hour sun exposure per day were independently found to have high risk for development of UFs. Vitamin D may have a role in growth of UFs. Women not able to get adequate sun exposure due to indoor working conditions may need evaluation and supplementation as prophylaxis for development of fibroid.

Vitamin D and its binding protein in patients with leiomyomas

“…Additionally, we did not observe a significant association between total VitD levels and the volume or number of leiomyomas. This contradicts previous studies that have shown a significant link between low serum levels of Vitamin D and the risk of developing uterine leiomyomas 18,26–28 . It is worth mentioning that we did find lower levels of total Vitamin D in leiomyoma patients compared to the healthy group, but this difference was not statistically significant.…”

“…This contradicts previous studies that have shown a significant link between low serum levels of Vitamin D and the risk of developing uterine leiomyomas. 18,[26][27][28] It is worth mentioning that we did find lower levels of total Vitamin D in leiomyoma patients compared to the healthy group, but this difference was not statistically significant. This could be attributed to the relatively small sample size of our study.…”