Association Between Serum Vitamin D Level and Ménière’s Disease

Abstract

Objectives Ménière’s disease (MD) is a well-known inner ear disease; however, the etiopathogenesis is unknown. Several factors may be involved. Meanwhile, vitamin D is reported to have an important role in inner ear physiology. The aim of this study is to evaluate the relation between vitamin D deficiency and MD. Study Design This matched case-control study compared serum vitamin D levels between patients with definite MD and those without it. Setting The study was done between August 2018 and December 2019 at Ghaem University Hospital in Mashhad, Iran. Methods Twenty-eight patients with definite MD were matched with a group of 84 healthy individuals, regarding age, sex, body mass index, and occupation (indoor vs outdoor). The serum level of vitamin D (25-hydroxyvitamin D3) was measured in both groups. Results The mean ± SD vitamin D level was 18.9 ± 9.7 ng/mL in the case group and 25.2 ± 13.7 ng/mL in the control group ( P = .027). There was a significant difference between the case and control groups according to the results of the conditional logistic regression model ( P = .03; adjusted odds ratio, 0.96). In the MD group, 17 (60.7%) patients were vitamin D deficient, 6 (21.4%) insufficient, and only 5 (17.9%) sufficient. Conclusions The results of this study show that serum vitamin D level in MD is significantly lower than that of the control group. However, the role of vitamin D supplementation in the management of MD needs further study. Level of evidence: 4.

Epidemiology and genetics of Meniere's disease

“…In addition, adult patients with osteoporosis also showed a higher risk of Meniere's disease [15]. Significantly lower serum vitamin D level was noted in another study [16]. Air pollution was also shown to be associated with higher hospital visits for Meniere's disease [17].…”

Vitamin D3 preserves blood retinal barrier integrity in an in vitro model of diabetic retinopathy

“…Hyperglycemia, oxidative stress and inflammation are detrimental events that compromise the stability and the expression of those proteins (Tien et al, 2013;Yuan et al, 2014;Platania et al, 2019). The protective effects of vitamin D 3 have been studied in different pathological systems, including eye diseases (Jia et al, 2019;Gouni-Berthold and Berthold, 2021;Johansson et al, 2021;Plesa et al, 2021;Bakhshaee et al, 2022). Beyond the role of vitamin D 3 in calcium and bone homeostasis, several evidence highlight the antiinflammatory, antioxidant and anti-angiogenic activity of this natural compound (Saad El-Din et al, 2020;Ghanavatinejad et al, 2021).…”

In silico pharmacological study of AQP2 inhibition by steroids contextualized to Ménière’s disease treatments

“…The second most significant inhibition of AQP2 function was observed with oestradiol. Interestingly, the fluctuation of these two steroid hormones has been correlated to MD symptoms (87)(88)(89)(90)(91). Coherently, in both cases, the steroid hormone deficiency was associated with hearing impairment (92)(93)(94)(95) and vertigo (96,97).…”