Association Between Serum Vitamin D Levels and Ketosis Episodes in Hospitalized Patients with Newly Diagnosed Ketosis-Prone Type 2 Diabetes

Abstract

This study aimed to investigate the relationship between 25-hydroxyvitamin D (25OHD) and the onset of ketosis in newly diagnosed patients with ketosis-prone type 2 diabetes (KPT2D). Patients and Methods: A total of 162 patients with non-autoimmune newly diagnosed diabetes mellitus were included in this crosssectional study. Patients were classified into KPT2D (n = 71) or non-ketotic type 2 diabetes (NKT2D, n = 91). Anthropometric parameters, islet functions, biochemical parameters, and body composition were determined in both KPT2D and NKT2D groups. Correlation analysis was performed to determine the associations between 25OHD and plasma ketones. The risk factors associated with ketosis episodes in patients with new-onset KPT2D were evaluated using binary logistic regression analysis. Results: Vitamin D deficiency was observed in both patients with KPT2D and NKT2D. Compared with the NKT2D group, serum 25OHD values were lower in the participants of the KPT2D group [14.20 (10.68, 19.52) vs 16.98 (13.54,2.96) ng/mL, P = 0.011]. Serum 25OHD was associated with plasma ketones (R = −0.387). Serum 25OHD is an independent protective factor for ketosis or ketoacidosis episodes in patients with new onset of KPT2D (P = 0.037, OR = 0.921). Conclusion:Vitamin D levels are associated with ketosis episodes in patients with KPT2D. Serum 25OHD is an independent protective factor for ketosis episodes in patients with KPT2D.

The impact of vitamin D on the etiopathogenesis and the progression of type 1 and type 2 diabetes in children and adults

“…Diabetic ketosis is one of the acute complications of diabetes mellitus. Serum 25(OH)D 3 levels are lower in ketosis-prone T2DM compared to non-ketosis-prone T2DM ( 39 , 40 ), and serum 25(OH)D 3 levels are related to the severity of pancreatitis concurrent with diabetic ketoacidosis ( 41 ).…”

Vitamin D, Parathyroid Hormone, Insulin Sensitivity and Islet <i>β</i>-Cell Secretory Function in Diabetic Patients from South Kivu in the Democratic Republic of Congo: Cross-Sectional Study

“…Also in Kenya, Said J et al did not find associations between insulin sensitivity, β-cell secretion and vitamin D in diabetic patients [13]. He X et al, in China, showed that low vitamin D levels were signifi-cantly associated with episodes of ketoacidosis in patients with atypical DM [14].…”

Association Between the Water Distribution in the Human Body and 25-Hydroxyvitamin D Among the Type 2 Diabetes Mellitus Population: A Possible Pathway Between Vitamin D and Diabetic Nephropathy

“…He et al reported a correlation between vitamin D and ketosis in their T2DM participants. 8 Tang et al found that a poor vitamin D status may be related to diabetic foot in Chinese T2DM participants. 9 Ahmed et al reported on the clinical value of vitamin D3 in diabetic retinopathy (DR) in the Qatari population with T2DM.…”