Association between serum visfatin levels and psoriasis and their correlation with disease severity: a meta-analysis

Abstract

Objective To determine the association between serum visfatin levels and psoriasis and to evaluate the correlation between serum visfatin levels and the severity of psoriasis. Methods The electronic databases PubMed®, Embase® and the Cochrane Library were searched for articles published from inception to 1 May 2020. Data were extracted and then standard mean differences (SMDs) and 95% confidence intervals (CIs) were calculated for pooled estimates. Results A total of 11 studies met the inclusion criteria and were included (448 patients diagnosed with psoriasis and 377 controls). This meta-analysis demonstrated that patients with psoriasis had significantly higher levels of visfatin than the controls (SMD = 0.90, 95% CI 0.52, 1.28). Subgroup analyses showed that differences in serum visfatin levels between the patient group and the control group were associated with ethnicity, Psoriasis Area and Severity Index (PASI) and body mass index. Additionally, a meta-analysis of correlations showed that visfatin levels in patients with psoriasis were positively correlated with PASI ( r = 0.51, 95% CI 0.14, 0.75). Conclusions This meta-analysis showed that serum visfatin levels in patients with psoriasis were significantly higher than those in the controls and a positive correlation between serum visfatin levels and psoriasis severity was observed.

Psoriasis and Cardiometabolic Diseases: Shared Genetic and Molecular Pathways

“…A similar trend has been observed for other adipokines in psoriasis, with an increase in those with proinflammatory effects, including resistin [ 188 , 190 ], chemerin [ 191 ], and visfatin [ 192 ], and a decrease in those with anti-inflammatory effects, such as omentin [ 182 , 183 ]. Even more significantly, healing of psoriasis following effective therapy results in the normalization of the aberrant levels of these molecules [ 185 , 191 ].…”

The Role of Adipokines in the Pathogenesis of Psoriasis

“…In addition, visfatin plays a regulatory role in cell proliferation and apoptosis [ 169 ]. A study by Zou and colleagues determined the associations between serum visfatin levels and psoriasis [ 170 ]. This meta-analysis showed that patients with psoriasis had significantly higher levels of visfatin than controls.…”

Epidemiology of Psoriasis and Comorbid Diseases: A Narrative Review

“…A meta-analysis including 11 studies demonstrated that psoriasis patients had higher levels of visfatin (SMD, 0.90; 95% CI, 0.52-1.28), which was associated with ethnicity, PASI, and BMI (34). Visceral fat was associated with psoriasis, hypertriglyceridemia, low high-density lipoprotein, and type 2 diabetes, and these associations were linked to serum IL-6, adiponectin, tumor necrosis factor, and insulin resistance (52).…”