Association between Serum Uric Acid Level and Activity of Daily Living in Japanese Patients with Ischemic Stroke

Kawase, Shinya; Kowa, Hisanori; Suto, Yutaka; Fukuda, Hiroki; Kusumi, Masayoshi; Nakayasu, Hiroyuki; Nakashima, Kenichiro

doi:10.1016/j.jstrokecerebrovasdis.2017.06.017

Cited by 8 publications

(5 citation statements)

References 38 publications

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“…Similar results were observed in several population studies [2][3][4][5]. By contrast, other studies have linked high SUA levels to hypertension, metabolic syndrome, renal disease, and reduced insulin sensitivity; some studies reported that high SUA level was also a risk factor for stroke prognosis, suggesting a U-shaped relationship between SUA and stroke prognosis [8,9,21]. This was likely because SUA levels are determined primarily by renal clearance function; patients with lower eGFR are more likely to have higher SUA levels, and renal dysfunction may be a major confounder in studies on the association between SUA and stroke prognosis.…”

Section: Discussionsupporting

confidence: 84%

Association between serum uric acid to serum creatinine ratio and poor functional outcomes in patients with acute ischemic stroke

Gong

Tian

Zhou

et al. 2022

Euro J of Neurology

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Background and purpose:The role of serum uric acid (SUA) in prognosis is controversial because SUA levels largely depend on renal clearance function. This study aimed to investigate the association between renal function-normalized SUA (SUA to serum creatinine [SCr] ratio [SUA/SCr ratio]) and poor functional outcomes in patients with acute ischemic stroke (AIS).Methods: All patients were recruited from the Third China National Stroke Registry. Poor functional outcomes were defined by modified Rankin Scale (mRS) scores of 3-6 or 2-6 at 3 months and 1 year.Results: Among 8169 enrolled patients, the median (interquartile range) SUA/SCr ratio was 4. 19 (3.47-5.08). Compared with patients in the fourth quintile group, those in the first quintile group had higher proportions of mRS scores 3-6 (odds ratio [OR] 1.55, 95% confidence interval [CI] 1.24-1.93) and mRS scores 2-6 (OR 1.28, 95% CI 1.08-1.53) at 3 months. The addition of SUA/SCr ratio to the conventional risk model had a greater incremental value than the addition of either SUA or SCr alone. Subgroup analysis showed that the association was only significant in patients with normal kidney function (p for interaction<0.05). Similar results were found for outcomes at 1 year. Conclusions:A lower SUA/SCr ratio was associated with poor functional outcomes in patients with AIS at 3 months and at 1 year, suggesting the potential use of SUA/SCr ratio in clinical practice as a preferable marker for stroke outcomes. K E Y W O R D Sacute ischemic stroke, poor functional outcomes, prognosis, serum uric acid to serum creatinine ratio Assessment of outcomesPatients were followed up for clinical outcomes at 3 months and 1 year after symptom onset. They were interviewed in-person at 3 months and contacted by telephone by trained research coordinators at 1 year. Functional outcomes were defined using the modified Rankin Scale (mRS) score, a measure of disability that is widely used for evaluating post-stroke recovery; mRS of 3-6 or 2-6 at 3 months and 1 year, respectively, were considered poor outcomes [17][18][19].All events were collected by trained research coordinators who remained blinded to subjects' baseline characteristics.

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Section: Discussionsupporting

confidence: 84%

Association between serum uric acid to serum creatinine ratio and poor functional outcomes in patients with acute ischemic stroke

Gong

Tian

Zhou

et al. 2022

Euro J of Neurology

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“…In Chongke Zhong's study, high serum uric acid levels were associated with increased risk of stroke in both men and women [ 27 ], while in the study by Storhaug, there was a significant difference between genders in terms of serum uric acid levels in ischemic stroke patients: they reported the level of uric acid was associated with a 31% increase in the risk of stroke in men [ 25 ] In a study by Kawase in 2017, although lower (SUA) level at the onset of ischemic stroke was associated with an increase in the incapacity of patients during the early hospitalization, this relationship was in the same way in both genders [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Relationship of Serum Uric Acid Level with Demographic Features, Risk Factors, Severity, Prognosis, Serum Levels of Vitamin D, Calcium, and Magnesium in Stroke

Saadat

Ahangar

Babaei

et al. 2018

Stroke Research and Treatment

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Introduction Stroke is one of the most common neurological disorders with high mortality rates. A large financial burden is imposed on the families and health systems of countries in addition to the problems related to the disabilities caused by the disease for the patients. Extensive research is being conducted on the disease, including studies seeking possible relationships between some biomarkers such as uric acid and stroke. Methods This descriptive-analytic cross-sectional study was conducted on 170 stroke patients at Babol Ayatollah Rohani Hospital during 2015-2016. Serum uric acid (SUA) levels were measured and recorded at admission time. Patients' demographic data as well as the stroke type and some of their risk factors were entered in a checklist. The data were analyzed by SPSS.v.23 using chi-square and logistic regression tests. P < 0.05 was considered as significant in all analyses. Results Of the total 170 included patients, 57% had normal, 25% had low, and the remaining patients (18%) had high SUA levels. There was no significant difference in SUA levels in different types of stroke in both genders. Diabetic ischemic embolic patients had higher levels of SUA than diabetic ischemic thrombotic cases. Patients with low magnesium levels had higher rate of low levels of SUA in ischemic stroke. Conclusion Serum uric acid levels are not associated with stroke types and gender. Diabetic embolic ischemic stroke cases had high SUA levels than thrombotic types and in ischemic stroke patients with low serum levels of magnesium, SUA levels were also lower.

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“…High SUA levels due to uric acid toxicity increase cardiovascular events, but when SUA levels are low, cardiovascular events are also increased; this analogous nding was observed in patients with vasospastic angina [21]. The effects of SUA are also the same in acute ischemic stroke patients [22].…”

Section: The Importance Of Reasonable Uric Acid Level In Gdmmentioning

confidence: 79%

The Protect Role of Serum Uric Acid to Premature Rupture of Membranes in Gestational Diabetes: a Cross-sectional Study

Guo

Lü

et al. 2020

Preprint

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Background: Uric acid has strong antioxidant activity whereas its oxidative damage is closely related to many diseases. We assessed the association between serum uric acid (SUA) levels and premature rupture of membranes (PROM) in pregnant women with Gestational diabetes (GDM) in china. Method: In this cross-sectional study, a total of 456 pregnant women were enrolled. Anthropometric parameters for pregnant women were collected within 12 weeks of gestation. Weight gain during pregnancy was obtained from patients’ record. GDM was diagnosed according to 75-g oral glucose tolerance tests at 24-28th week’s gestation, and SUA was determined simultaneously. PROM was identified as the natural rupture of fetal membranes before the first stage of labor. Logistic models were fitted to identify the presence of PROM using clinical characteristics with (Model 1) or without serum uric acid (Model 2).Results: There exist differences in BMI, haemoglobin A1c, fasting blood glucose, 1-hour postprandial glucose, 2h PG, insulin levels, weight gain during pregnancy, the rate of macrosomia, PROM between women with and without GDM (all P<0.05). Furthermore, individuals with PROM had lower level of SUA than those without PROM in GDM women (P=0.030). The odds ratio of PROM decreases with the increase of SUA level. The area under the receiver operating characteristic curves for PROM based on Model 1 was larger than that in Model 2 (0.86 versus 0.71, p<0.05).Conclusion: Elevated relatively SUA levels at the 24-28th weeks of gestation were associated with a lower risk of PROM in women with GDM. SUA may be a protective factor for PROM in GDM patient. The optimal concentration of uric acid in different diseases and different populations needs to be further studied.

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Association between Serum Uric Acid Level and Activity of Daily Living in Japanese Patients with Ischemic Stroke

Cited by 8 publications

References 38 publications

Association between serum uric acid to serum creatinine ratio and poor functional outcomes in patients with acute ischemic stroke

Association between serum uric acid to serum creatinine ratio and poor functional outcomes in patients with acute ischemic stroke

Relationship of Serum Uric Acid Level with Demographic Features, Risk Factors, Severity, Prognosis, Serum Levels of Vitamin D, Calcium, and Magnesium in Stroke

The Protect Role of Serum Uric Acid to Premature Rupture of Membranes in Gestational Diabetes: a Cross-sectional Study

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