Association between serum uric acid and metabolic syndrome: a cross-sectional study in Bangladeshi adults

Ali, Nurshad; Miah, Rakib; Hasan, Mahmudul; Barman, Zitu; Mou, Ananya Dutta; Hafsa, Jaasia Momtahena; Trisha, Aporajita Das; Hasan, Akibul; Islam, Farjana

doi:10.1038/s41598-020-64884-7

Cited by 103 publications

(110 citation statements)

References 47 publications

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“…MetS was diagnosed based on the criteria of the National Cholesterol Education Program – Adult Treatment Panel III (NCEP-ATP III) [ 27 ]. The variables of MetS were defined as follows: i) Elevated blood pressure (SBP ≥130 mmHg and/or DBP ≥85 mmHg or antihypertensive medication intake); ii) raised waist circumference (> 102 cm for men and > 88 cm for women); iii) hypertriglyceridemia (TG ≥150 mg/dL); iv) hyperglycemia (FBG ≥100 mg/dL) and v) low HDL-C (< 40 mg/dL for men and < 50 mg/dl for women) [ 19 ] . MetS was identified among the participants who had at least three of the above components.…”

Section: Methodsmentioning

confidence: 99%

“…Briefly, body weight was measured to the nearest 0.10 kg by a digital weighing machine (Beurer 700, Germany) and body height was measured to the nearest 0.10 cm by height measuring tape wearing light clothes and no shoes. The body mass index (BMI) was calculated as body weight in killograms divided by height in meters squared [19]. Waist circumference (WC) was measured using a general tape that was placed midway between the lowest border of the ribs and iliac crest.…”

Section: General Data Collectionmentioning

confidence: 99%

“…The venous blood samples were obtained after 10-12 h overnight fasting from the participants [19]. Then the samples were centrifuged at 3000 rpm for 15 min and isolated serum was stored at -20°C until analysis.…”

Section: Blood and Urine Sample Collection And Laboratory Analysismentioning

confidence: 99%

“…A review by Chowdhury et al [ 18 ] reported a high prevalence of MetS (30%) in the Bangladeshi population. A very recent study showed the prevalence of MetS 22% in general adults with 21.9% in males and 22.1% in females [ 19 ]. A few studies conducted in Eastern Asia showed a relationship between microalbuminuria and MetS but generated inconsistent results with the components of MetS [ 12 – 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Association of microalbuminuria with metabolic syndrome: a cross-sectional study in Bangladesh

Saadi¹,

Roy

Haque

et al. 2020

BMC Endocr Disord

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Background and aims The objectives of this study were to estimate the prevalence of microalbuminuria and examine the association of microalbuminuria with metabolic syndrome (MetS) and its component in a Bangladeshi adult cohort. Methods This cross-sectional study included 175 subjects (84 males and 91 females; aged 19–59 years), recruited from the outdoor Department of Medicine and Endocrinology of a medical college hospital in Dhaka, Bangladesh. Lipid profile and fasting blood glucose (FBG) were measured in serum and albumin and creatinine were determined in urine samples. Microalbuminuria was defined as the urinary albumin-to-creatinine ratio (ACR) of 30 to 300 mg/g. The MetS was defined according to the criteria of the National Cholesterol Education Program (NECP). The association of microalbuminuria with MetS and its components was evaluated by multivariate logistic regression analysis. Results Among the study subjects, 66.3% were hypertensive and 70.3% were diabetic individuals. Overall, the prevalence of microalbuminuria was 29.7% with 31% in males and 28.6% in females. Microalbuminuria was 2.6 fold higher in hypertensive and diabetic adults than in the non-hypertensive or non-diabetic adults. The prevalence of microalbuminuria was much more frequent in persons with the MetS (36.0%) than the persons without the MetS (5.4%). The levels of FBG, systolic blood pressure (SBP), diastolic blood pressure (DBP) and triglycerides were significantly higher (p < 0.01 for all cases) in subjects with microalbuminuria. In regression analysis, after adjusting for sex, age, and body mass index, microalbuminuria was strongly correlated with MetS followed by elevated BP and FBG (p < 0.01 for all cases). Conclusions Microalbuminuria was strongly associated with MetS in Bangladeshi adults. Elevated BP and FBG were the most predominant components of MetS among the study subjects. Comprehensive management of MetS at its early stage can be effective to prevent and reduce the progression of kidney injury and cardiovascular complications.

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Section: Methodsmentioning

confidence: 99%

Section: General Data Collectionmentioning

confidence: 99%

Section: Blood and Urine Sample Collection And Laboratory Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association of microalbuminuria with metabolic syndrome: a cross-sectional study in Bangladesh

Saadi¹,

Roy

Haque

et al. 2020

BMC Endocr Disord

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“…Uric acid is correlated to metabolic syndrome (Ali et al, 2020). Hence, this research was conducted to identify the correlation of uric acid levels and NASH in NAFLD (Non-Alcoholic Fatty Liver Disease) with and without obesity.…”

Section: Introductionmentioning

confidence: 99%

Correlation between Uric Acid and Non-Alcoholic Steatohepatitis (NASH) Occurred in Obesity and Non-Obesity

Rasdiana¹,

Hp²,

Akil³

et al. 2020

GJHS

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BACKGROUND/AIM: Non-alcoholic Fatty Liver Disease (NAFLD) is one of the main causes that promote chronic liver disease in developing countries. Uric acid is correlated to metabolic syndrome. Based on this issue, we studied the correlation between uric acid level and the occurrence of NASH in non-alcoholic fatty liver disease (NAFLD) with or without obesity.  METHODS: The research subjects were 149 patients diagnosed with NAFLD. The data were collected from the medical record by purposive sampling method. The subjects were taken from inpatient and outpatient data from Wahidin Sudirohusodo hospital. The medical record included demography, clinical, radiology and laboratory records. Statistical analysis were performed through descriptive statistical calculations, Pearson Correlation and multinomial logistic. RESULTS: There was a significant correlation between NAFLD and uric acid level (p=.000). Based on gender, the correlation between NAFLD and uricemia was significant in female patients (with p=.000); but insignificant in male patients (p=.137). Based on age, in age of >40 years old, NAFLD was significantly associated with uric acid level (p=.000). There was a significant correlation between hyperuricemia and NASH in obese and non-obese patients (p <0.001) for which the higher the uric acid level the greater the NAFLD degree was. CONCLUSION: There is a correlation between uric acid level and NASH occurrence in NAFLD with or without obesity.

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Altered Risk of Incident Gout According to Changes in Metabolic Syndrome Status: A Nationwide, Population‐Based Cohort Study of 1.29 Million Young Men

Eun

Han

Lee

et al. 2023

Arthritis & Rheumatology

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Objective. Few data are available on whether changes in metabolic syndrome affect incident gout. This study was undertaken to assess associations between metabolic syndrome status and incident gout, as well as changes in the clinical characteristics of metabolic syndrome and incident gout, in a cohort of young men.Methods. This nationwide, population-based cohort study included 20-39-year-old men who participated in serial health check-ups. The outcome, incident gout, was defined according to the claims database diagnostic code for gout. Associations among changes in metabolic syndrome status and incident gout were analyzed using Cox proportional hazards models.Results. Among 1,293,166 individuals, 18,473 were diagnosed as having gout (incidence rate 3.36 per 1,000 personyears). Subjects who had chronic metabolic syndrome (defined as metabolic syndrome at all 3 health check-ups) had a nearly 4-fold higher risk of incident gout compared to subjects who did not have metabolic syndrome at any of the 3 health check-ups (adjusted hazard ratio [HR adj ] 3.82 [95% confidence interval (95% CI) 3.67-3.98]). Development of metabolic syndrome more than doubled the risk of incident gout (HR adj 2.31 [95% CI 2.20-2.43]). Conversely, recovery from metabolic syndrome reduced the risk of incident gout by nearly half (HR adj 0.52 [95% CI 0.49-0.56]). Among metabolic syndrome components, changes in elevated triglycerides (development of elevated triglycerides, HR adj 1.74 [95% CI 1.66-1.81]; recovery from elevated triglycerides, HR adj 0.56 [95% CI 0.54-0.59]) and abdominal obesity (development of abdominal obesity, HR adj 1.94 [95% CI 1.85-2.03]; recovery from abdominal obesity, HR adj 0.69 [95% CI 0.64-0.74]) showed the greatest association with altered risk of incident gout. Associations between changes in the status and clinical characteristics of metabolic syndrome and incident gout were more pronounced in subjects ages 20-29 years compared to those ages 30-39 years, and in subjects who were underweight or who had a normal weight.Conclusion. Changes in the status and clinical characteristics of metabolic syndrome were associated with altered risk of incident gout. These results suggest that metabolic syndrome is a modifiable risk factor for gout.

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Association between serum uric acid and metabolic syndrome: a cross-sectional study in Bangladeshi adults

Cited by 103 publications

References 47 publications

Association of microalbuminuria with metabolic syndrome: a cross-sectional study in Bangladesh

Association of microalbuminuria with metabolic syndrome: a cross-sectional study in Bangladesh

Correlation between Uric Acid and Non-Alcoholic Steatohepatitis (NASH) Occurred in Obesity and Non-Obesity

Altered Risk of Incident Gout According to Changes in Metabolic Syndrome Status: A Nationwide, Population‐Based Cohort Study of 1.29 Million Young Men

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