Association Between Serum Uric Acid and Intracranial Arterial Stenosis in a Korean Population: A Secondary Analysis Based on a Cross-Sectional Study

Yao, Taotao; Di, Anqi; Li, Jialing; Zhang, Shuchen; He, Jiang; Xu, Nuo; Xu, Danghan

doi:10.3389/fneur.2022.791456

Cited by 3 publications

(3 citation statements)

References 28 publications

(31 reference statements)

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“…It can therefore protect nerves from oxidative damage during an acute stroke and prevent worse outcomes [ 14 , 18 , 19 ]. However, elevated uric acid was also reported to promote atherosclerotic progression by increasing the production of free radicals and facilitating low-density lipoprotein cholesterol oxidation [ 35 ]; to increase the level of inflammatory cytokines; to increase platelet aggregation and thrombus formation [ 36 ]; and to be associated with carotid intima-media thickness [ 37 ], proximal extracranial artery stenosis [ 38 ], and intracranial arterial stenosis [ 39 ]. Playing various roles in these mechanisms, uric acid functions as a double-edged sword.…”

Section: Discussionmentioning

confidence: 99%

J-Shaped Relationship of Serum Uric Acid with Unfavorable Short-Term Outcomes among Patients with Acute Ischemic Stroke

et al. 2022

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(1) Background: The role of uric acid in stroke outcomes remains inconclusive. (2) Methods: We retrospectively enrolled 3370 patients with acute ischemic stroke. (3) Results: Uric acid level was higher in men than in women. Univariate analyses revealed that the rates of hyperuricemia were higher in all patients and in women for unfavorable outcomes. For death, the hyperuricemia rates were higher in all patients including men and women, and the uric acid levels were also higher in all patients and in women. A J-shaped curve was observed between uric acid and the discharge-modified Rankin Scale score. Patients within Quartiles 1 (<4.1 mg/dL) and 4 (>6.5 mg/dL) of uric acid had higher rates of unfavorable outcomes and death than patients within Quartiles 2 (4.1–5.1 mg/dL) and 3 (5.1–6.2 mg/dL). Multivariable analyses for unfavorable outcomes revealed that Quartile 1 of uric acid was a significant factor in all patients and in men. In men, a significant factor for death was being in Quartile 1 of uric acid. In women, higher levels of uric acid or hyperuricemia (>6.6 mg/dL) were significant factors for death. (4) Conclusions: Lower uric acid levels are a predictor for unfavorable outcomes and death in men, and higher uric acid levels are a predictor for death in women.

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Section: Discussionmentioning

confidence: 99%

J-Shaped Relationship of Serum Uric Acid with Unfavorable Short-Term Outcomes among Patients with Acute Ischemic Stroke

et al. 2022

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“…All the data used in the current work originated from Lee et al’s article ( 28 ), a published open-access article. The data was also used in a secondary study by Yao et al ( 29 ) published in Frontiers in Neurology . Lee et al’s research ( 28 ) was a cross-sectional study based on a Korean population.…”

Section: Methodsmentioning

confidence: 99%

Association between estimated pulse wave velocity and silent lacunar infarct in a Korean population

Zhou

Shang

2023

Front. Cardiovasc. Med.

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AimsPrevious studies have proposed the estimated pulse wave velocity (ePWV) as a simple and cost-effective measure of arterial stiffness. Since arterial stiffness plays a role in the progression of silent lacunar infarct (SLI), our present work aims to evaluate the association between ePWV and the presence of SLI.MethodsThe present work was based on a cross-section study. Our study included 1,011 neurologically healthy Korean participants. The SLI was evaluated using brain magnetic resonance images (MRI). The ePWV was derived from a published equation using age and mean blood pressure (MBP). Logistic regression analyses were performed to investigate the association between ePWV and SLI. The linear relationship and robustness were evaluated using smooth curve fitting and subgroup analyses, respectively.ResultsThe prevalence of SLI was 11.87%. After fully adjusting for covariates, per 1 m/s increase of ePWV casted 31% additional risk for SLI (P = 0.009). When dividing the ePWV into quartiles, the top quartile had 4.01 times risk compared with the bottom quartile. The increasing trend across the quartiles was statistically significant (P for trend < 0.001). Consistently, smooth curve fitting revealed that the risk of SLI elevated linearly with the increase of ePWV. Finally, subgroup analysis suggested that the association was robust in several sub-populations divided by age, sex, smoking, hypertension, diabetes mellitus (DM), coronary artery occlusive disease (CAOD), hyperlipidemia, and statin medication (all P for interaction > 0.05).ConclusionThe current study revealed an independent and positive association between ePWV and the presence of SLI in a neurologically healthy Korean population.

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“…More detailed information is displayed on the website "https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143355." The data were also used in our previous research [26] and Yao et al's research [27]. The source research for our present analyses has obtained approval from the CHA Bundang Medical Center (IRB No.…”

Section: Data Sourcementioning

confidence: 99%

Estimated Pulse Wave Velocity is Associated with Intracranial Arterial Stenosis: A Secondary Analysis Based on A Korean Population

Zhou,

Shang,

Tang

et al. 2024

Human Brain

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The estimated pulse wave velocity (ePWV) was recently proposed to indicate artery stiffness. Although arterial stiffness contributes to intracranial arterial stenosis (ICAS), the correlation between ePWV and ICAS remains unclear. This secondary analysis included 1,011 neurologically healthy Korean participants from a cross-sectional database to explore the association between ePWV and prevalent ICAS. Brain magnetic resonance angiography (MRA) was performed for all patients at their presentation to access the ICAS. The ePWV was derived as: ePWV = 9.587 − 0.402 × age + 4.560 × 10 −3 × age2 − 2.621 × 10-5 × age2 × mean blood pressure (MBP) + 3.176 × 10-3 × age × MBP – 1.832 ×10-2 × MBP. The prevalence of ICAS was 9.99% (n=101). In multivariable logistic regression analyses, per 1m/s increment of ePWV causes 1.36 times the risk of ICAS prevalence after fully adjusting potential confounders. When dividing ePWV into tertiles, the ICAS risk increased by 1.98 times when ePWV increased from the first tertile to the third tertile. Moreover, the relationship between ePWV and ICAS was linear and robust, as suggested by smooth curve fitting and stratification analysis. In conclusion, the ePWV was positively and independently associated with prevalent ICAS in the Korean population.

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Association Between Serum Uric Acid and Intracranial Arterial Stenosis in a Korean Population: A Secondary Analysis Based on a Cross-Sectional Study

Cited by 3 publications

References 28 publications

J-Shaped Relationship of Serum Uric Acid with Unfavorable Short-Term Outcomes among Patients with Acute Ischemic Stroke

J-Shaped Relationship of Serum Uric Acid with Unfavorable Short-Term Outcomes among Patients with Acute Ischemic Stroke

Association between estimated pulse wave velocity and silent lacunar infarct in a Korean population

Estimated Pulse Wave Velocity is Associated with Intracranial Arterial Stenosis: A Secondary Analysis Based on A Korean Population

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