Association between serum uric acid level and metabolic syndrome components

Abstract

BackgroundSerum uric acid levels is reported to be associated with a variety of cardiometabolic risk factors; however, its direct association with metabolic syndrome (MetS) remains controversial. Thus, we examined the association of serum uric acid concentrations with the MetS components.MethodsMetS was defined according to the National Cholesterol Education Program (NCEP) criteria. This case–control study comprised 101 non-smoking individuals (41 in the MetS group and 60 in the non-MetS group). Blood pressure, fasting plasma glucose, insulin, HOMA-IR, lipid profiles, uric acid, and anthropometric measures were determined, and body composition was assessed by using bioelectrical impedance analysis (BIA).ResultsAfter adjustment for confounding factors, serum uric acid was significantly higher in MetS group than non-MetS group (5.70 ± 1.62 vs 4.97 ± 1.30 mg/dL, respectively, P = 0.001). After controlling for age, sex and body mass index in partial correlation analysis, uric acid was positively correlated with triglycerides, and negatively with HDL-C. In multiple logistic regression analysis, every 1 mg/dl elevation in the serum uric acid level increased the risk of MetS approximately by 2-folds (OR: 2.11, 95 % CI: 1.30-3.41).ConclusionThis study showed that those individuals with MetS have higher uric acid levels; the association of uric acid and MetS components supports that it might be an additional components of MetS.

Prevalence of metabolically obese but normal weight (MONW) and metabolically healthy but obese (MHO) in Chinese Beijing urban subjects

“…Little information on its association with MetS in Chinese population is available. Consistent with the previous finding, Pearson's correlation analyses in this work suggests that hyperuricemia is more correlated with MetS in males than in females (24). Our findings also suggested that UAC and TG could be a risk factor for MetS.…”

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“…Additionally, our cases showed higher uric acid levels which is in accordance with Nejatinamini et al 37 who reported that uric acid and MS components supports might be an additional components of MS. Uric acid may not only acts as surrogate marker of MS, but also have a pathogenic role in the development of MS, and therapies that lower uric acid may improve certain components of MS 38 . Although hyperuricemia is recognized as a risk factor for obesity, diabetes and MS, the precise physiological mechanisms by which uric acid contribute to these diseases state remain unclear 39 .…”

Analysis of Uric Acid Elevation

“…Hyperuricemia has been found to be associated with metabolic syndrome (26)(27)(28). It has been emphasized that an increase in uric acid levels that is recognized early can be a sign of metabolic syndrome that may develop (29).…”

“…An increased uric acid level is an independent risk factor in metabolic syndrome (34). Nejatinami et al (28) made the interpretation that an increased uric acid level was one of the risk factors of metabolic syndrome in the results of a study that they conducted. They expressed the opinion that hyperuricemia should be included as an additional component of metabolic syndrome.…”