Association between serum uric acid levels and dyslipidemia in Chinese adults

Chen, Shenghui; Yang, Hua; Chen, Yishu; Wang, Jinghua; Xu, Lei; Miao, Min; Xu, Chengfu

doi:10.1097/md.0000000000019088

Cited by 24 publications

(24 citation statements)

References 25 publications

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“…One meta-analysis in Chinese indicated that SUA was significantly associated with dyslipidemia and its components, and hyperuricemia increased the likelihood of dyslipidemia. 40 Our results were in accordance with this meta-analysis. Based on our data, SUA levels had a remarkable association with CRFs, and with the increase of SUA level, the clustering degree of cardiovascular risk factors also increased in both genders.…”

Section: Discussionsupporting

confidence: 92%

Associations of Serum Uric Acid with Clustering of Cardiovascular Risk Factors and a 10-Year Atherosclerotic Cardiovascular Disease Risk Score in Jiangsu Adults, China

Tian¹,

Wang²,

Xie³

et al. 2021

DMSO

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Purpose The relationship between serum uric acid (SUA) and Chinese characteristic 10-year atherosclerotic cardiovascular disease (ASCVD) risk score has not been well evaluated in Chinese populations. Aims of this cross-sectional study were to describe the correlation between SUA level and clustering of prevalent cardiovascular risk factors (CRFs) including overweight, central obesity, hypertension, diabetes and dyslipidemia, as well as the Chinese 10-year ASCVD risk score in adults from Jiangsu Province located in Eastern China. Patients and Methods A total of 7700 adults from 12 cities in Jiangsu Province were selected through multi-stage stratified cluster random sampling method in 2015. Face-to-face interviews, physical examinations and laboratory examinations were carried out to collect the information of the participants. Multivariate logistic analysis was used to analyze the relationship between SUA quartiles and various CVD risk factors. The nonlinear analysis was conducted to evaluate the relationship between SUA levels and the China-PAR 10-year ASCVD risk scores. Results The prevalence of hyperuricemia was 13.3% in all of the participants. By adjusting potential confounders, significant correlations were found between the SUA level and the overweight, central obesity, hypertension and dyslipidemia in both males and females. The clustering of CRFs was different across SUA quantiles ( χ 2 =607.685, P <0.001). After Gamma trend test ( P < 0.001) and ordered logistic regression analysis, it was found out that with the increase of SUA quantiles, prevalent CRFs gradually gathered in both males and females. Furthermore, sex-specific difference was identified between SUA and 10-year ASCVD risk scores. Conclusion The accumulation of CRFs increased with elevated SUA levels, whereas it was different between genders in the relationship between SUA and 10-year ASCVD risk scores. Tailored strategies should be taken when it came to males and females in managing SUA.

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Section: Discussionsupporting

confidence: 92%

Associations of Serum Uric Acid with Clustering of Cardiovascular Risk Factors and a 10-Year Atherosclerotic Cardiovascular Disease Risk Score in Jiangsu Adults, China

Tian¹,

Wang²,

Xie³

et al. 2021

DMSO

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“…Our findings suggest that urate may be causally related to HDL-C levels. This supports a previous meta-analysis demonstrating a significant inverse relationship between urate and HDL-C ( Chen et al, 2020b ), although longitudinal studies reported inconsistent findings ( Gonçalves et al, 2012 ; Babio et al, 2015 ). One small study observed significantly higher HDL-C after 3 months of allopurinol administration, a xanthine oxidase inhibitor used for hyperuricemia treatment ( Ziga and Becic, 2013 ).…”

Section: Discussionsupporting

confidence: 89%

Causal Associations of Urate With Cardiovascular Risk Factors: Two-Sample Mendelian Randomization

et al. 2021

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BackgroundMendelian Randomization (MR) studies show conflicting causal associations of genetically predicted serum urate with cardiovascular risk factors (i.e., hypertension, diabetes, lipid profile, and kidney function). This study aimed to robustly investigate a causal relationship between urate and cardiovascular risk factors considering single nucleotide polymorphisms (SNPs) as instrumental variables using two-sample MR and various sensitivity analyses.MethodsData on SNP-urate associations were taken from the Global Urate Genetics Consortium and data on SNP-cardiovascular risk factor associations were taken from various consortia/UK Biobank. SNPs were selected by statistically and biologically driven approaches as instrumental variables. Various sensitivity analyses were performed using different MR methods including inverse variance weighted, MR-Egger, weighted median/mode, MR-PRESSO, and the contamination mixture method.ResultsThe statistically driven approach showed significant causal effects of urate on HDL-C and triglycerides using four of the six MR methods, i.e., every 1 mg/dl increase in genetically predicted urate was associated with 0.047 to 0.103 SD decrease in HDL-C and 0.034 to 0.207 SD increase in triglycerides. The biologically driven approach to selection of SNPs from ABCG2, SLC2A9, SLC17A1, SLC22A11, and SLC22A12 showed consistent causal effects of urate on HDL-C from all methods with 0.038 to 0.057 SD decrease in HDL-C per 1 mg/dl increase of urate, and no evidence of horizontal pleiotropy was detected.ConclusionOur study suggests a significant and robust causal effect of genetically predicted urate on HDL-C. This finding may explain a small proportion (7%) of the association between increased urate and cardiovascular disease but points to urate being a novel cardiac risk factor.

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“…Based on the existing literature, we speculate that the sudden increase in UA after living donation might result in the poor recovery of renal function through endothelial dysfunction,(9) in ammation, vasoconstriction, (10,11) and increased COX-2 expression (12), which may eventually lead to hypertension, (51,52) hyperglycemia, and dyslipidemia. (53,54) In fact, prior studies have suggested that hyperuricemia is associated with the occurrence of hypertension (51,52) and dyslipidemia (53,54) in the non-CKD population. In the CKD population, a randomized control study revealed that a 1 mg/dL increase in the UA level was associated with a 17% increased risk of all-cause mortality (HR = 1.17) and a 16% increased risk of cardiovascular disease mortality (HR = 1.16).…”

Section: Discussionmentioning

confidence: 99%

Long-Term Impact of Baseline Serum Uric Acid Levels On Living Kidney Donors: A Retrospective Study

Tanaka

Yamanaga

Hidaka

et al. 2021

Preprint

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Background: Preoperative characteristics of living kidney donors are commonly considered during donor selection and postoperative follow-up. However, the impact of preoperative uric acid (UA) levels is poorly documented. The aim of this study was to evaluate the association between preoperative serum UA levels and post-donation long-term events and renal function.Methods: This was a single-center retrospective analysis of 183 living kidney donors. The donors were divided into high (≥5.5 mg/dl) and low (<5.5 mg/dl) UA groups. We analyzed the relationship between preoperative UA levels and postoperative estimated glomerular filtration rate (eGFR), as well as adverse events (cardiovascular events and additional prescriptions for hypertension, gout, dyslipidemia, and diabetes mellitus), over 5 years after donation. Results: In total, 44 donors experienced 52 adverse events over 5 years. The incidence of adverse events within 5 years was significantly higher in the high UA group than in the low UA group (50% vs. 24%, p = 0.003); this was true even after the exclusion of hyperuricemia-related events (p = 0.047). UA emerged as an independent risk factor for adverse events (p = 0.012). Donors with higher UA levels had lower eGFRs after donation, whereas body mass index, hemoglobin A1c, blood pressure, and low-density lipoprotein cholesterol did not have any impact on the eGFR.Conclusions: The findings suggest that preoperative UA levels should be considered during donor selection and postoperative follow-up.

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Association between serum uric acid levels and dyslipidemia in Chinese adults

Abstract: Supplemental Digital Content is available in the text

Cited by 24 publications

References 25 publications

Associations of Serum Uric Acid with Clustering of Cardiovascular Risk Factors and a 10-Year Atherosclerotic Cardiovascular Disease Risk Score in Jiangsu Adults, China

Associations of Serum Uric Acid with Clustering of Cardiovascular Risk Factors and a 10-Year Atherosclerotic Cardiovascular Disease Risk Score in Jiangsu Adults, China

Causal Associations of Urate With Cardiovascular Risk Factors: Two-Sample Mendelian Randomization

Long-Term Impact of Baseline Serum Uric Acid Levels On Living Kidney Donors: A Retrospective Study

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