Association Between Serum Uric Acid and Depression in Patients with Chronic Kidney Disease not Requiring Kidney Dialysis: Cross-Sectional and Longitudinal Analyses

Gao, Bin; Song, Xinyuan; Hao, Jie; Han, Yingying; Zhang, Miaomiao; Sun, Ning; Li, Jinping; Qi, Ping; Uchida, Shunya; Chang, Wenxiu

doi:10.12659/msm.925386

Cited by 4 publications

(4 citation statements)

References 44 publications

(44 reference statements)

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“…Regarding psychological status, 11 studies (55%) showed that depression was associated with poor sleep quality (Afsar, 2013, 2014; Chen et al, 2022; Gao et al, 2020; Han et al, 2020; Iliescu et al, 2004; Kumar et al, 2010; Tu et al, 2019; Yamamoto et al, 2018; Yazıcı & Güney, 2022; Zhang et al, 2014). Certain behaviours including smoking (Afsar, 2013) and cognitive arousal activities (i.e.…”

Section: Resultsmentioning

confidence: 99%

“…The reasons for studies with fair quality were that they did not meet the requirements in the selection and comparability aspects of the NOS scale. For instance, the study (Yamamoto et al, 2018) did not present the representativeness of the exposed cohort; the selection of the non‐exposed cohort and study (Gao et al, 2020) did not show the comparability of cohorts on the basis of design or analysis.…”

Section: Resultsmentioning

confidence: 99%

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Factors associated with poor sleep quality in patients with pre‐dialysis chronic kidney disease: A systematic review

Huang

Cheng

Yen

2023

Journal of Advanced Nursing

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Aims: To determine factors associated with poor sleep quality among patients with pre-dialysis chronic kidney disease. Design: This is a systematic review study guided by Preferred Reporting Items for Systematic Reviews and Meta-Analyses statements and checklist. Data Sources: Empirical evidence was sought in major electronic databases, including Embase, MEDLINE, CINAHL and Airiti library from March to September 2022. Review Methods: Studies investigating factors associated with poor sleep quality among adult patients with chronic kidney disease were included. Study participants who received renal replacement therapy and had sleep disorders and serious illnesses such as cancer were excluded. Of the 526 studies that resulted from the search after removing duplicate articles, 20 studies were assessed for quality by using Joanna Briggs Institute and Newcastle-Ottawa Scale by two doctorial prepared nursing scientists.Results: A total of 20 studies were included in this review. The prevalence of poor sleep quality in these studies ranged from 11% to 97.5%. Demographics (older age and female), physiological conditions (higher body mass index, higher hip circumferences, higher systolic blood pressure, poor cardiovascular function, dyspnoea, pain, cramps, itchiness or moderate to extreme pruritus, lower fasting plasma glucose, electrolyte imbalance, higher total cholesterol and gastrointestinal symptoms), depression, smoking, arousal-related and cognitive arousal behaviours were associated with poor sleep quality. Conclusion: Poor sleep quality was prevalent and influenced kidney function, increased mortality as well as decreased quality of life in patients with pre-dialysis chronic kidney disease. This review synthesizes factors associated with poor sleep quality. Managing these factors can mitigate and prevent poor sleep quality. Impact: Healthcare providers, especially nurses, can assess the risk factors of poor sleep quality and reinforce patients' self-management. Future research should elucidate the assessment and management of risk factors and transfer these into widespread use in the routine care of patients with chronic kidney disease.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Factors associated with poor sleep quality in patients with pre‐dialysis chronic kidney disease: A systematic review

Huang

Cheng

Yen

2023

Journal of Advanced Nursing

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“…The relatively lower prevalence of depression in our MHD patients was similar to that of other two reports. 40,41 This lower rate of depression might be mainly caused by two reasons. First one is that patients diagnosed with neurological and psychiatric disorders prior to beginning dialysis therapy and patients with long-term drug abuse were excluded.…”

Section: Discussionmentioning

confidence: 99%

Decreased Intracellular to Total Body Water Ratio and Depressive Symptoms in Patients with Maintenance Hemodialysis

Tian,

Qian,

Long

et al. 2023

PRBM

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Objective Depression is a common psychiatric disorder and related to poor outcomes in patients undergoing maintenance hemodialysis (MHD). Previous studies have reported some associations between sarcopenia and depressive symptoms. Recently, intracellular water (ICW) and total body water (TBW) have been found to reflect muscle function and muscle mass. ICW/TBW ratio is a marker of sarcopenia that is simple to assess. However, the relationship between ICW/TBW ratio and depression has not been explored in MHD patients. Methods In our cross-sectional and multi-center study, 3300 adult MHD patients were included from June 1, 2021, to August 30, 2021. Depressive symptoms were evaluated using the Beck Depression Inventory-II (BDI-II). TBW and ICW were measured by Body Composition Monitor (BCM). Multivariable logistic regression, stratified analyses, and interactive analyses were conducted to assess the relationship between ICW/TBW ratio and depression. Results About 16.5% of the 3300 MHD patients were found to have depressive symptoms. The prevalence of depression increased with decreasing quartiles of ICW/TBW ratios, and decreased ICW/TBW ratio was independently associated with depression after adjusting for potential confounders. Patients in Quartile 1 of ICW/TBW ratios were more likely to have depressive symptoms (odds ratio 1.55, 95% confidence interval 1.07–2.22; p =0.002) than those in Quartile 4. History of diabetes and education status had interactive roles in the relationship between depression and ICW/TBW ratios ( p < 0.05). The association of ICW/TBW ratios and depression existed in patients of both genders and different education levels, but only in non-diabetic patients. Conclusion In MHD patients, the decreased ratio of ICW/TBW was independently related to high depression rates.

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“…In this study, we considered the significant impact of various other factors, such as uric acid, potassium, calcium, phosphorus, and PTH, on neurological and psychological functions. Incorporating the potential influence of these factors is essential, because uric acid may affect mental wellbeing through neuroinflammatory processes [12], and the potassium level, along with the balance between calcium and phosphorus, may influence mood and the functioning of the nervous system [13,14]. This comprehensive approach allows for a more nuanced exploration of the connections between different components and depressive symptoms in patients undergoing hemodialysis.…”

Section: Introductionmentioning

confidence: 99%

The Plasma Neurofilament Light Chain, Brain-Derived Neurotrophic Factor, and Risk of Depression in Chronic Hemodialysis Patients

Stanisławska,

Roman,

Nowicki

2024

Biomedicines

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Introduction: Depression is highly prevalent among hemodialysis patients. Understanding the relationship between the plasma neurofilament light chain (NfL) and brain-derived neurotrophic factor (BDNF) may help us to better understand the mechanisms of depression. This study determined their impact, alongside that of other factors, on the risk of depression in hemodialysis patients. Methods: The study enrolled 82 patients undergoing chronic hemodialysis. Serum NfL, BDNF, uric acid, urea, potassium, calcium, phosphorus, intact parathyroid hormone, and C-reactive protein (CRP) levels were measured. The patients completed the Beck Depression Inventory (BDI). Blood pressure values, body mass before and after hemodialysis, and weekly duration of hemodialysis in hours were assessed. For 19-month survival analysis, the patients were stratified according to baseline BDI scores. Results: Based on the BDI score, 18.3% of the patients had an increased risk of depression. Lower scores were associated with significantly longer duration of hemodialysis treatment (37.5 (25–57) 24 (14–37) months, p = 0.01). Within the 19-month survival analysis, 31.7% of patients died. The patients with BDI scores above the median had significantly lower survival than those below the median (log-rank test p = 0.02). No significant differences in serum BDNF levels (192.7 [125.2–278.2]; 207.7 [142.8–265.8] pg/mL, p = 0.40), or NfL concentrations (1431.5 [1182.6–1625.7]; 1494.6 [1335.7–1667] kDa, p = 0.52) were found between patients with lower and higher risk of depression. Patients with BDI scores above the median had significantly higher levels of CRP (9.6 [4.4–14]) than those with scores below the median (3.6 [2.2–7.5], p = 0.01). A significant positive correlation was found between the BDI score and serum CRP level (r = 0.38, p = 0.01). A significant negative correlation was observed between the BDI score and URR% value (r = −0.36, p = 0.02). Conclusions: Patients with lower BDI scores had a longer dialysis duration, indicating a potential negative association between depression risk and length of dialysis treatment. Neither serum NfL nor BDNF levels can serve as markers of depression risk in the dialysis population.

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Association Between Serum Uric Acid and Depression in Patients with Chronic Kidney Disease not Requiring Kidney Dialysis: Cross-Sectional and Longitudinal Analyses

Cited by 4 publications

References 44 publications

Factors associated with poor sleep quality in patients with pre‐dialysis chronic kidney disease: A systematic review

Factors associated with poor sleep quality in patients with pre‐dialysis chronic kidney disease: A systematic review

Decreased Intracellular to Total Body Water Ratio and Depressive Symptoms in Patients with Maintenance Hemodialysis

The Plasma Neurofilament Light Chain, Brain-Derived Neurotrophic Factor, and Risk of Depression in Chronic Hemodialysis Patients

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