Association Between Serum Total Bilirubin and Serum Creatinine and the Effect of Hypertension

Santhanam, Prasanna; Khitan, Zeid; Khthir, Rodhan

doi:10.1111/jch.12452

Cited by 5 publications

(4 citation statements)

References 7 publications

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“…Meanwhile, there is a positive correlation between hsa_circ_0037909 and LDL. The relationship between serum creatinine and hypertension has been released . Luan et al also found that circRNAs have a positive correlation with serum creatinine and act as a sponge for hsa‐miR‐150 .…”

Section: Discussionmentioning

confidence: 99%

Up‐regulation of circular RNA hsa_circ_0037909 promotes essential hypertension

Bao

Zheng

et al. 2019

Clinical Laboratory Analysis

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AimsEssential hypertension (EH) is a high prevalence disease facing a public health challenge. People were little known about the genetics of diagnosing the cause of EH. Circular RNAs that have a continuous cycle of covalent closure, without affected by RNA exonuclease, and are more stable and hard to degrade may involve into the molecule regulation mechanism of EH as an important biomedical.MethodsqRT‐PCR was used to analyze circRNAs in total volume of human blood and the induced human aortic endothelial cells (HAECs) and human umbilical vein endothelial cells (HUVECs). Our case‐control study was involved with 48 pairs of case controls with sex and age (±3 years) match. We conducted t test, Pearson's χ2 test, and receiver operating characteristics (ROC) curve analysis for the corresponding analysis.ResultsThe expression level of hsa_circ_0037909 in EH patients was significantly higher than that in the healthy controls (P = 0.007), and the expression level of hsa‐miR‐637 in EH patients was significantly lower in than that in the healthy controls (P = 0.039); the same result appears in the HAECs and HUVECs. Hsa‐miR‐637 (adjusted P = 0.018), hsa_circ_0037909 (adjusted P = 0.005), HDL (adjusted P = 0.024), and serum creatinine (adjusted P = 0.014) were brought into the model which performed logistic regression analysis. The combination of two RNAs was excellent (P < 0.001) through ROC curve analysis. Hsa_circ_0037909 was significantly positively correlated with serum creatinine (P < 0.001) and low‐density lipoprotein (LDL) (P = 0.017).ConclusionsOur findings suggested that the combination of hsa_circ_0037911 and hsa‐miR‐637 may be a significant important biomarker for early diagnosis of EH. Hsa_circ_0037909 may affect serum creatinine or LDL leading to the formation of EH.

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Section: Discussionmentioning

confidence: 99%

Up‐regulation of circular RNA hsa_circ_0037909 promotes essential hypertension

Bao

Zheng

et al. 2019

Clinical Laboratory Analysis

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“…In contrast to the finding of the previous meta-analysis, we observed a positive association between the serum creatinine concentration and T2DM risk in hypertensive subjects. The reason for this finding is not clear, but we hypothesize that the expression of creatine kinase in hypertensive patients is abnormal (22,23). High creatine kinase activity promotes HTN through enhanced vascular contractility and sodium retention in the kidneys.…”

Section: Discussionmentioning

confidence: 85%

“…High creatine kinase activity promotes HTN through enhanced vascular contractility and sodium retention in the kidneys. Creatine kinase is tightly bound near ATPases and catalyzes the conversion of creatine to creatinine in serum (22). The specific physiological mechanisms need to be investigated in future studies.…”

Section: Discussionmentioning

confidence: 99%

The risk factors of type 2 diabetes in hypertensive subjects

Chen

Lü

et al. 2022

Front. Endocrinol.

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ObjectiveHypertension (HTN) and type 2 diabetes (T2DM) share common risk factors and usually co-occur. This study examined the relationship between HTN history and T2DM incidence in a cohort of Chinese hypertensive subjects.MethodsWe recruited 443 cases (T2DM and HTN) and 443 sex- and age-matched controls (HTN). The history of peak systolic blood pressure (SBP) was divided into 140-159, 160-179, and ≥ 180 mmHg, and that of peak diastolic blood pressure (DBP) was divided into 90-99, 100-109, and ≥ 110 mmHg. Multiple binary logistic regression models were used to explore the association between controlled HTN status and T2DM.ResultsCreatinine concentrations were higher in the cases than in the controls (P < 0.05). The HTN duration was longer in the cases than in the controls (14.7 years vs. 13.2 years; P < 0.05). Significant differences were also found in the history of peak SBP and DBP between the cases and controls (both P < 0.05). Creatinine, HTN duration, and family history of T2DM were risk factors for T2DM in hypertensive subjects, with odds ratios (95% confidence intervals) of 1.013 (1.004-1.022), 1.025 (1.003-1.047), and 5.119 (3.266-8.026), respectively. Compared with the lowest level of peak DBP, the odds ratio for T2DM at the highest level of peak DBP was 1.757 (1.074-2.969). Subgroups analyses showed that the effect of the history of peak DBP on T2DM was significantly modified by sex (P-interaction = 0.037).ConclusionThe highest DBP and the longest HTN duration were both independently associated with T2DM in hypertensive subjects.

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“…It also affects the serum level of liver enzymes of neonates as it decreases the level of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and serum alkaline phosphatase (ALP) [7]. Some studies about the effect of phototherapy on kidney functions in neonates revealed that phototherapy decrease the level of serum creatinine, serum urea, and serum uric acid [8]. The current study aims to assess the effect of phototherapy on liver enzymes, renal functions, and serum electrolytes in NH patients before and after phototherapy.…”

Section: Introductionmentioning

confidence: 99%

Effect of Phototherapy on Electrolytes, Liver and Kidney Functions During Treatment of Neonatal Hyperbilirubinemia. A Prospective-Analytical Study

Abohussein

Khalil²,

Fahmy

2022

Annals of Neonatology Journal

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Background: Neonatal jaundice is a frequent problem affecting the newborn with various etiologies. Although phototherapy is considered the standard treatment for neonatal hyperbilirubinemia, it has some complications, as erythematous rashes, diarrhea, hyperthermia and electrolyte disturbance. Objective: To assess the effect of phototherapy on liver enzymes, renal functions, and serum electrolytes in jaundiced neonates before and after phototherapy and to assess changes in biochemical parameters according to mode of treatment including using Bilisphere then phototherapy, IVIG & Bilisphere then phototherapy and phototherapy only. Methods: One hundred neonates with unconjugated hyberbilirubinemia were enrolled. Jaundiced neonates were placed under phototherapy at a distance of 45-50 cm. Laboratory investigations were done before and after phototherapy. Results: Mean (± SD) TSB and DSB significantly declined after phototherapy with p value <0.001. Also, Mean (± SD) levels of AST and ALT showed statistically significant decrease after phototherapy (p<0.001). In addition, Mean (± SD) creatinine and urea levels showed statistically significant decrease after phototherapy (p<0.001).We also found statistically significant decrease in potassium and Calcium levels (p-value < 0.001) after treatment. As regards mode of treatment, we found a statistical significant decrease in TSB, creatinine and calcium among the different modes of treatment (p<0.001). Conclusion: Neonatal hyperbilirubinemia is considered a treatable condition and much of its ill-effects can be eliminated by proper intervention.However, continuous observation of electrolytes as potassium, sodium and calcium is needed as disturbance in their levels is of concern.

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Association Between Serum Total Bilirubin and Serum Creatinine and the Effect of Hypertension

Cited by 5 publications

References 7 publications

Up‐regulation of circular RNA hsa_circ_0037909 promotes essential hypertension

Up‐regulation of circular RNA hsa_circ_0037909 promotes essential hypertension

The risk factors of type 2 diabetes in hypertensive subjects

Effect of Phototherapy on Electrolytes, Liver and Kidney Functions During Treatment of Neonatal Hyperbilirubinemia. A Prospective-Analytical Study

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