Association between serum total antioxidant capacity and mortality in severe septic patients

Lorente, Leonardo; Martı́n, Marı́a; Almeida, Teresa; Abreu-González, Pedro; Ferreres, José; Solé‐Violán, Jordi; Labarta, Lorenzo; Díaz, César; Jiménez, Alejandro

doi:10.1016/j.jcrc.2014.09.012

Cited by 35 publications

(48 citation statements)

References 33 publications

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“…In most cases, the investigated patient cohorts were divided according to the median or the quartiles of the investigated population, which yielded different cut-off values. Taken together, an elevated RDW could be proven to be an independent and powerful predictor for adverse events in a large number of clinical settings, i.e., in patients suffering from cardiovascular diseases or septic shock 13,[17][18][19] . There are also some very interesting and well-performed studies, which have focused on the impact of RDW estimation at the time point of ICU admission in terms of its mortality predicting value.…”

Section: Discussionmentioning

confidence: 99%

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Red cell distribution width and survival in patients hospitalized on a medical ICU

Fujita

Franz

Figulla

et al. 2015

Clinical Biochemistry

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Section: Discussionmentioning

confidence: 99%

“…To date, this relationship is best investigated in cardiovascular patients 8 , but has, amongst others, also been demonstrated in patients with kidney injury 9 , metabolic syndrome 10 , bowel disease 11 and septic shock 12,13 . In these studies, RDW not only predicted survival but also strongly correlated with morbidity.…”

Section: Introductionmentioning

confidence: 99%

Red cell distribution width and survival in patients hospitalized on a medical ICU

Fujita

Franz

Figulla

et al. 2015

Clinical Biochemistry

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“…This assay has also been widely used in clinical practice (e.g. Lorente et al, 2015). Mean CV of assay values was 3.3% (N=34 samples; 17 males, 17 females).…”

Section: Oxidative Stress Assaysmentioning

confidence: 99%

Oxidative stress as an indicator of the costs of reproduction among free-ranging rhesus macaques

Georgiev

Thompson

Mandalaywala

et al. 2015

Journal of Experimental Biology

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Sex differences in longevity may reflect sex-specific costs of intrasexual competition and reproductive effort. As male rhesus macaques experience greater intrasexual competition and die younger, we predicted that males would experience greater oxidative stress than females and that oxidative stress would reflect sex-specific measures of reproductive effort. Males, relative to females, had higher concentrations of 8-OHdG and malondialdehyde, which are markers of DNA oxidative damage and lipid peroxidation, respectively. Older macaques had lower 8-OHdG levels than younger ones, suggesting that oxidative stress decreases in parallel with known age-related declines in reproductive investment. Among males, a recent period of social instability affected oxidative status: males who attacked others at higher rates had higher 8-OHdG levels. Multiparous lactating females with daughters had higher 8-OHdG levels than those with sons. No differences in antioxidant capacity were found. These results lend initial support for the use of oxidative stress markers to assess trade-offs between reproductive effort and somatic maintenance in primates.

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“…In a study carried out by our team on 213 severely septic patients (to our knowledge, the largest series providing data on serum TAC in septic patients), we found that serum TAC levels were higher in non-survivors than in survivors. The novel finding of our study was that serum TAC levels were associated with mortality in severely septic patients (32). Our Cox regression analysis revealed that serum TAC levels were associated with survival at 30 days (hazard ratio, 1.50; 95% CI, 1.16 to 1.94; P = 0.002) after controlling for lactic acid levels, APACHE-II score, and renal failure.…”

Section: Circulating Levels Of Total Antioxidant Capacitymentioning

confidence: 58%

New Prognostic Biomarkers of Mitochondrial Oxidative Stress in Septic Patients

Lorente¹

2015

Arch Crit Care Med

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Context: Sepsis is a common, expensive, and frequently fatal condition that is associated with as many deaths annually as is acute myocardial infarction. Evidence Acquisition: Sepsis could alter different pathways and cause inflammation, coagulation, apoptosis, and mitochondrial oxidative stress and dysfunction. This review focuses on new prognostic biomarkers of mortality due to mitochondrial oxidative stress in septic patients. Results: Recently some biomarkers of mitochondrial oxidative stress have been associated with prognosis in septic patients; they include circulating levels of malondialdehyde, total antioxidant capacity, melatonin level, platelet level of cytochrome c oxidase (COX) or mitochondrial respiratory complex IV, and mitochondrial deoxyribonucleic acid (mtDNA) haplogroup. Conclusions: Some biomarkers of mitochondrial oxidative stress (e.g. circulating levels of malondialdehyde, total antioxidant capacity, melatonin level, platelet level of COX, mtDNA haplogroup) have been recently associated with mortality in septic patients. These biomarkers could assist in the prognostic classification of septic patients and open new research lines in their treatment.

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Association between serum total antioxidant capacity and mortality in severe septic patients

Cited by 35 publications

References 33 publications

Red cell distribution width and survival in patients hospitalized on a medical ICU

Red cell distribution width and survival in patients hospitalized on a medical ICU

Oxidative stress as an indicator of the costs of reproduction among free-ranging rhesus macaques

New Prognostic Biomarkers of Mitochondrial Oxidative Stress in Septic Patients

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