Association between serum progesterone concentration in early pregnancy and duration of pregnancy: a cohort study

Shen, Shi‐Li; Chen, Qiao Zhu; Zhang, Li Fang; He, Jian; Lu, Jinhua; Li, Wei Dong; Xiao, Wan Qing; Zhou, Ze Hong; Morse, Abraham N.; Cheng, Kar Keung; Mol, Ben W.; Xia, Hui; Qiu, Xiu

doi:10.1080/14767058.2018.1540580

Cited by 3 publications

(4 citation statements)

References 28 publications

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“…While the outcomes might be affected by inclusion criteria and progesterone treatment, similar to our results, low levels of progesterone were not found to be associated with risk of preterm birth. [10] Besides, progesterone level can be affected by different parameters. It has been shown that the first-trimester maternal BMI is inversely proportional to the serum progesterone level.…”

Section: Discussionmentioning

confidence: 99%

“…Relationship between first trimester progesterone concentrations and third-trimester gestational complications, such as hypertensive disorders, intrauterine growth restriction, oligohydramnios and preterm delivery, as well as low birth weight, were also investigated in few studies. [8][9][10] In a recent study, low serum progesterone concentration during early pregnancy was found to be associated with an increase in hypertensive disorders of pregnancy in univariate analysis, but this relationship was not confirmed in multivariate analysis. [8] This study also demonstrated that low progesterone level in the first trimester is associated with low birth weight.…”

Section: Introductionmentioning

confidence: 95%

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Does maternal serum progesterone level in early pregnancy predict placental dysfunction in third trimester?

Durdağ¹,

Baran²,

Alemdaroğlu³

et al. 2021

Perinatal J

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Objective Progesterone, which is necessary for maintenance of pregnancy, is secreted by corpus luteum until 10 weeks of gestation, and is produced from the placenta afterwards. Aim of this study is to investigate the relationship of serum progesterone concentrations measured in 6–8 weeks and 12 weeks of gestation with the parameters that may demonstrate placental dysfunction in the third trimester. Methods Relationship of the progesterone values measured at 6–8 weeks and 12 weeks of gestation with indicators of placental dysfunction, including hypertensive disorders of pregnancy, intrauterine growth restriction, preterm delivery and low birth weight, were evaluated. Furthermore, based on a previous study, two groups with progesterone levels below and above 11 ng/mL in early pregnancy were formed, and the difference between these groups regarding gestational outcomes were investigated. Results Progesterone concentrations at 6–8 and 12 weeks of gestation were not significantly different between the subgroups with and without gestational complications indicating placental dysfunction (p>0.05 for all parameters). As for the two groups, significant difference was not found in terms of third trimester complications due to progesterone cut-off of 11 ng/mL at 6-8 weeks of gestation. Conclusion In this study, we did not find progesterone values measured at early and late first trimester periods to be associated with placental dysfunction in the third trimester. Also, we did not validate a previously suggested threshold value to predict gestational outcome. Therefore, routine first trimester progesterone screening in guiding pregnancy follow-up may not be appropriate.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Does maternal serum progesterone level in early pregnancy predict placental dysfunction in third trimester?

Durdağ¹,

Baran²,

Alemdaroğlu³

et al. 2021

Perinatal J

View full text Add to dashboard Cite

show abstract

“…Progesterone levels have been reported to be higher in cases of iatrogenic PTB than that in the group of the term birth at 9 to 14 weeks and 28 to 32 weeks 7 . In addition, lower concentrations of serum progesterone at 4–10 weeks of gestation are not associated with a shortened gestation period or higher risk of PTB 8 . It should be noted that iatrogenic preterm labor, preterm premature rupture of membranes (pPROM), and spontaneous premature birth (sPTB) have different etiologies, and that their hormone levels may also differ.…”

Section: Mechanisms Of Progesterone-mediated Immune Tolerance and Inf...mentioning

confidence: 99%

“…7 In addition, lower concentrations of serum progesterone at 4-10 weeks of gestation are not associated with a shortened gestation period or higher risk of PTB. 8 It should be noted that iatrogenic preterm labor, preterm premature rupture of membranes (pPROM), and spontaneous premature birth (sPTB) have different etiologies, and that their hormone levels may also differ. International Federation of Gynecology and Obstetrics (FIGO) indicated that progesterone can be used to prevent PTB.…”

Section: Progesterone Levels In Ptbmentioning

confidence: 99%

Mechanisms of Immune Tolerance and Inflammation via Gonadal Steroid Hormones in Preterm Birth

Shen,

Li,

Cao

et al. 2023

Maternal Fetal Med

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In 2019, preterm births (PTB) accounted for approximately 0.66 million deaths globally. PTB is also associated with a significantly higher risk of mortality and long-term complications for newborns. Long-term studies associated several factors, including disruption of immune tolerance and inflammation, with PTB. However, the pathogenesis of PTB remains unclear. Gonadal steroid hormones are critical for pregnancy maintenance and regulation of immune and inflammatory responses. However, it is not clear how unbalanced gonadal steroid hormones, such as imbalanced estrogen/androgen or estrogen/progesterone contribute to PTB. In this review, we discuss how gonadal steroid hormones mediate dysfunction in immune tolerance and inflammatory responses, which are known to promote the occurrence of PTB, and provide insight into PTB prediction.

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Progesterone increases hepatic lipid content and plasma lipid levels through PR- B-mediated lipogenesis

Jeong,

Mukae,

Lee

et al. 2024

Biomedicine & Pharmacotherapy

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Association between serum progesterone concentration in early pregnancy and duration of pregnancy: a cohort study

Cited by 3 publications

References 28 publications

Does maternal serum progesterone level in early pregnancy predict placental dysfunction in third trimester?

Does maternal serum progesterone level in early pregnancy predict placental dysfunction in third trimester?

Mechanisms of Immune Tolerance and Inflammation via Gonadal Steroid Hormones in Preterm Birth

Progesterone increases hepatic lipid content and plasma lipid levels through PR- B-mediated lipogenesis

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