Association between serum osteocalcin level and visceral obesity in Chinese postmenopausal women

Luo, Yuqi; Ma, Xiaojing; Hao, Yaping; Xu, Yiting; Xiong, Qian; Tang, Junling; Pan, Xiaoping; Xiao, Yunfeng; Bao, Yuqian; Jia, Weiping

doi:10.1111/cen.12793

Cited by 18 publications

(11 citation statements)

References 33 publications

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“…Interestingly, OC levels maintain their association with improved glucose tolerance and insulin secretion and sensitivity, independent of plasma adiponectin level [27]. The negative correlation between abdominal obesity and serum OC was confirmed by other studies in different ethnic groups [28,29].…”

Section: Osteocalcin Glucose and Lipid Metabolismsupporting

confidence: 57%

Osteocalcin as a potential risk biomarker for cardiovascular and metabolic diseases

Magni

Macchi

Sirtori

et al. 2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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Clear evidence supports a role for circulating and locally-produced osteocalcin (OC) in the pathophysiology of cardiovascular (CV) lesions and CV risk, also in combination with metabolic changes, including type 2 diabetes mellitus (T2DM). Reduced plasma OC levels are associated with greater incidence of pathological CV changes, like arterial and valvular calcification, coronary and carotid atherosclerosis and increased carotid intima-media thickness. The actual relationship between OC levels and incidence of major CV events is, however, still unclear. Moreover, reduced circulating OC levels have been mostly associated with insulin resistance, metabolic syndrome or T2DM, indicating relevant OC actions on pancreatic β-cells and insulin secretion and activity. Based on these observations, this review article will attempt to summarize the current evidence on the potential usefulness of circulating OC as a biomarker for CV and metabolic risk, also evaluating the currently open issues in this area of research.

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Section: Osteocalcin Glucose and Lipid Metabolismsupporting

confidence: 57%

Osteocalcin as a potential risk biomarker for cardiovascular and metabolic diseases

Magni

Macchi

Sirtori

et al. 2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…Maddaloni et al suggested that circulating OCN + monocytes could be a marker for vascular disease in diabetic patients [ 21 ]. Our previous studies found that a decreasing trend in serum OCN levels accompanied an increase in VFA, and VFA was inversely correlated with serum OCN levels [ 11 , 12 ]. Serum FGF23 levels were independently and positively correlated with the presence of lowerextremity atherosclerotic disease among Chinese patients with type 2 diabetes mellitus [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…Studies in human subjects have also revealed correlations between the levels of these hormones and obesity. Our previous studies reported significant positive correlations between both serum FGF23 and NGAL levels and obesity [ 9 , 10 ], whereas serum OCN levels were significantly inversely correlated with obesity [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Correlations between serum concentration of three bone-derived factors and obesity and visceral fat accumulation in a cohort of middle aged men and women

Pan

et al. 2018

Cardiovasc Diabetol

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BackgroundThe aim of this study was to investigate the interrelationships between three bone-derived factors [serum osteocalcin (OCN), fibroblast growth factor (FGF) 23, and neutrophil gelatinase-associated lipocalin (NGAL) levels] and body fat content and distribution, in order to reveal the potential endocrine function of bone in the development of obesity.MethodsWe recruited 1179 people (aged 59.5 ± 6.2 years) from communities in Shanghai. Serum OCN levels were determined using an electrochemiluminescence immunoassay. Serum FGF23 and NGAL levels were determined using a sandwich enzyme-linked immunosorbent assay. The abdominal fat distribution, including visceral fat area (VFA), was assessed by magnetic resonance imaging. Visceral obesity was defined as a VFA ≥ 80 cm2.ResultsSerum OCN levels were inversely correlated with body fat parameters, while FGF23 and NGAL were positively correlated (P < 0.05). After adjusting for confounders, waist circumference (W) and VFA had a closer relationship with serum OCN, FGF23, and NGAL levels than body mass index (BMI) and body fat percentage (fat%, all P < 0.05). The risk of visceral obesity significantly increased with higher FGF23 and/or NGAL levels, as well as with reduced OCN levels (all P < 0.05). In addition, serum OCN, FGF23, and NGAL levels were independently associated with visceral obesity (all P < 0.01). The relationships persisted among subjects with normal glucose tolerance or subjects with hyperglycaemia (both P < 0.05).ConclusionsCompared to the indicators of overall adiposity such as BMI or fat%, visceral adiposity indicators (W or VFA) were more closely related to serum OCN, FGF23 and NGAL levels. There was no interaction among the relationship of three bone-derived factors with visceral obesity, which revealed the independent relationship of endocrine function of skeleton with body fat.Electronic supplementary materialThe online version of this article (10.1186/s12933-018-0786-9) contains supplementary material, which is available to authorized users.

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“…Study characteristics for 21 eligible studies are summarized in ▶table 1. Studies were conducted on both healthy subjects and pa-tients, including 8 on healthy people [27,31,[36][37][38][39][40], 6 on post-menopausal women [37,[41][42][43][44][45], 3 on those with coronary heart disease [36,39,46], 3 on patients with type 2 diabetes [47][48][49], and 1 on women with polycystic ovary syndrome [50]. Four studies provided data for two different type of participants separately [31,36,37,39].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The quality of the included studies varied from 5-8 points on 10-point Newcastle-Ottawa scale. Seven studies scored 8 stars [27,37,40,42,44,48], five studies scored 7 stars [38,39,43,45], 7 studies scored 6 stars [36,41,46,47,49,50] and 2 studies scored 5 stars [31]. The age range of studies was between 18-69 years old.…”

Section: Study Characteristicsmentioning

confidence: 99%

The Association Between Osteocalcin and C-Reactive Protein; A Relation of Bone with Inflammation: A Systematic Review and Meta-Analysis

et al. 2019

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A meta-analysis was performed to summarize the evidence from observational studies regarding the association between serum osteocalcin (OC) and C-reactive protein (CRP). A systemic research of the literature databases including PubMed, SCOPUS, and Google Scholar was performed to identify the relevant studies up to March 2018. We used the random-effects model by the method of DerSimonian and Laird to calculate the overall effect size. Q-test and I 2-statistics were used to assess between-study heterogeneity. In addition, we did subgroup analysis to detect possible sources of heterogeneity based on BMI range, gender, type of study population and age. We identified 21studies of association between serum osteocalcin and CRP eligible for the meta-analysis. The overall effect size showed a significant inverse association between OC and CRP (Fisher’s z=–0.127; 95% CI: –0.166, –0.088, p<0.0001). However, the significant chi-squared statistic result, indicates a heterogeneity of effect sizes (I 2=61.6, df=20, p<0.0001). The subgroup analysis found BMI range, type of study population, and age were the potential sources of heterogeneity. In addition, the strongest correlation was observed in the subgroup of obese subjects (Fisher’s z=–0.264, p=0.002), less than 40 years old (Fisher’s z=–0.115, p<0.0001) and healthy subjects (Fisher’s z=–0.115, p<0.0001). These findings suggest that there is a significant inverse association between serum OC and CRP levels in the adult population.

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Association between serum osteocalcin level and visceral obesity in Chinese postmenopausal women

Abstract: The serum osteocalcin level was inversely correlated with the visceral fat content in these Chinese postmenopausal women.

Cited by 18 publications

References 33 publications

Osteocalcin as a potential risk biomarker for cardiovascular and metabolic diseases

Osteocalcin as a potential risk biomarker for cardiovascular and metabolic diseases

Correlations between serum concentration of three bone-derived factors and obesity and visceral fat accumulation in a cohort of middle aged men and women

The Association Between Osteocalcin and C-Reactive Protein; A Relation of Bone with Inflammation: A Systematic Review and Meta-Analysis

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