Association Between Serum Nitric Oxide Level and Changes in Thyroid Function Test in a Population-based Study: Tehran Thyroid Study Participants (TTS)

Abstract

Background: Nitric oxide (NO) plays a key role in thyroid function regulation through the inhibition of iodide (I) uptake at the thyroidal sodium-iodide symporter (NIS) and impacts the thyroid vascularity and blood flow. Objectives: This study aimed to evaluate the association between serum NO metabolites (NOx) and thyroid-stimulating hormone (TSH), free thyroxin (FT4), and anti-thyroid peroxidase (TPOAb) changes. Also, it aimed at evaluating the correlation between serum NOx and the incidence of clinical hypothyroidism, characterized by elevated TSH level and decreased FT4 concentration, and subclinical hypothyroidism, characterized by mildly elevated TSH level despite FT4 concentration within the normal range, over three years of follow-up. Methods: This study included 1,137 participants of the Tehran Thyroid study (TTS), aged > 20 years old, for whom data on serum TSH, FT4, and TPOAb in the third and fourth phases, and serum NOx in the third phase were available. Changes in TSH (ΔTSH), FT4 (ΔFT4), and TPOAb (ΔTPO) between the third and fourth phases were calculated, and the associations between serum NOx and ΔTSH, ΔFT4, and ΔTPOAb were assessed after multivariable adjustment using linear regression analysis. Results: No significant association was found between serum NOx and ΔTSH, ΔFT4, and ΔTPOAb after the multivariable adjustment; neither was any observed in TPOAb split groups after multivariable adjustment. No significant association was found between serum NOx tertiles and clinical and subclinical hypothyroidism incidence in the fourth phase of TTS. Conclusions: There was no association between serum NOx levels and changes in TSH, FT4, and TPOAb and clinical and subclinical hypothyroidism incidence.

Relationship between serum nitric oxide of patients with thyroid disorders and metabolic syndrome indices and nitrate concentration of water

“…asked. They concluded that there is no relationship between serum nitric oxide and thyroid hormones 45 2, the mean NO 3 concentration of drinking water in the case and control groups was 21.43 ± 13.92 and 20.46 ± 14, respectively. Figure 3 shows a box plot of the distribution of nitrate levels in drinking water in the control group and patients with thyroid disorders.…”

“…asked. They concluded that there is no relationship between serum nitric oxide and thyroid hormones 45 .…”

Effects of Astragalus Polysaccharides on iNOS-NO Induced by Lipopolysaccharide in Human Thyroid Cells

“…。NO 是甲状腺组织及细胞内重要的信息分子，由一氧化氮 合酶(Nitric oxide synthase，NOS)合成，参与一系列 甲状腺生理及病理过程 [5][6][7]。 传统中药黄芪 (Astragalus， AGs) 的主要成分黄芪多糖 (Astragalus polysaccharides， APS)是由己糖醛酸、葡萄糖、果糖、阿拉伯糖、半乳 糖醛酸和葡萄糖醛酸等组成，APS 具有抗病毒、抗肿 瘤、抗辐射、抗氧化应激等免疫促进或调节作用 [8][9]。 新近的研究发现：黄芪对自身免疫性甲状腺疾病和甲 状腺恶性肿瘤具有治疗作用 [10]。本研究观察 APS 对…”