Association between serum levels of TSH and free T4 and per- and polyfluoroalkyl compounds concentrations in pregnant women

Li, Aijing; Hou, Jian; Fu, Jianjie; Wang, Yinan; Hu, Yifei; Zhuang, Taifeng; Li, Menglong; Song, Maoyong; Jiang, Guibin

doi:10.1016/j.jes.2021.10.026

Cited by 11 publications

(6 citation statements)

References 49 publications

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Section: Discussionmentioning

confidence: 99%

“…PFBA, used as an additional replacement of PFOA in the USA 37 , was detected with comparable or slightly higher levels than PFOA in this study, indicating the widespread use of and exposure to PFAS alternatives. PFBA is a short-chain PFAS that has not received a great deal of regulatory scrutiny as it is rapidly excreted, despite its association with thyroid hormone levels in humans 38 and systemic toxicity in a murine model. 37 Other analytes, including PFPeA, PFOA, PFNA, PFDA, PFUnA, PFTrDA, and 9Cl-PF3ONS, were also detected in over 50% of cord blood samples but at generally lower concentrations compared to existing literature where comparisons existed.…”

Section: Comparison With Existing Literaturementioning

confidence: 99%

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Characterization of Per- and Polyfluoroalkyl Substance (PFAS) concentrations in a community-based sample of infants from Samoa

Heinsberg,

Niu,

Arslanian

et al. 2023

Preprint

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Per- and polyfluoroalkyl substances (PFAS) are persistent contaminants with documented harmful health effects. Despite increasing research, little attention has been given to studying PFAS contamination in low- and middle-income countries, including Samoa, where there is more recent modernization and potential window to examine earlier stages of PFAS exposure and consequences. Using data and biosamples collected through theFoafoaga o le Ola(“Beginning of Life”) Study, which recruited a sample of mothers and infants from Samoa, we conducted an exploratory study to describe concentrations of 40 PFAS analytes in infant cord blood collected at birth (n=66) and dried blood spots (DBS) collected at 4 months post-birth (n=50). Of the 40 PFAS analytes tested, 19 were detected in cord blood, with 11 detected in >10% of samples (PFBA, PFPeA, PFHpA, PFOA, PFNA, PFDA, PFUnA, PFTrDA, PFHxS, PFOS, and 9Cl-PF3ONS); 12 analytes were detected in DBS, with 3 detected in >10% of samples (PFBA, PFHxS, and PFOS). PFAS concentrations were generally lower than those reported in existing literature, with the exception of PFHxS, which was detected at higher concentrations. In cord blood, we noted associations between higher PFHxS and male sex, higher PFPeA and residence in Northwest ‘Upolu (NWU) compared to the Apia Urban Area (AUA), and lower PFUnA and 9Cl-PF3ONS with greater socioeconomic resources. In DBS, we found associations between higher PFBA and greater socioeconomic resources, and between lower PFBA and PFHxS and residence in NWU versus AUA. However, the latter association did not hold when controlling for socioeconomic resources. Finally, we observed associations between nutrition source at 4 months and DBS PFBA and PFHxS, with formula- or mixed-fed infants having higher concentrations compared to exclusively breastfed infants. This study presents the first evidence of PFAS contamination in Samoa. Additional work in larger samples is needed to identify potentially modifiable determinants of PFAS concentrations, information that is critical for informing environmental and health policy measures.

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Section: Discussionmentioning

confidence: 99%

Section: Comparison With Existing Literaturementioning

confidence: 99%

Characterization of Per- and Polyfluoroalkyl Substance (PFAS) concentrations in a community-based sample of infants from Samoa

Heinsberg,

Niu,

Arslanian

et al. 2023

Preprint

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“…111,112 There is an association between thyroid hormone (involved in the early development of the fetus) levels and short-chain PFASs concentrations in pregnant women. 113 The toxicity or mechanism of action of these common replacements is understudied, and investigations across species are required. In soil, their higher solubility and bioavailability may make them readily available for plant uptake.…”

Section: Environmental Fate and Potential Hazards Of Soil Pfassmentioning

confidence: 99%

“…Hexafluoropropylene-oxide-dimer-acid (GenX) and perfluoro ([5-methoxy-1,3-dioxolan-4-yl]oxy) acetic acid (C6O4) as common substitutes are shown to have the ability to form stable complexes with human serum albumin (hSA), though the affinity is weaker compared to those of the long-chain ones. , Short-chain PFASs in the bloodstream can also distribute throughout the body and ultimately accumulate and cause detrimental health effects in the body. GenX has been proven to have similar adverse effects on human health to those of PFOA and PFOS. , Reports about the adverse effects of C6O4 on organisms started to appear. , There is an association between thyroid hormone (involved in the early development of the fetus) levels and short-chain PFASs concentrations in pregnant women . The toxicity or mechanism of action of these common replacements is understudied, and investigations across species are required.…”

Section: Environmental Fate and Potential Hazards Of Soil Pfassmentioning

confidence: 99%

PFASs in Soil: How They Threaten Human Health through Multiple Pathways and Whether They Are Receiving Adequate Concern

Xing

Chen

et al. 2023

J. Agric. Food Chem.

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Per-and polyfluoroalkyl substances (PFASs) have been mass-produced and widely applied in consumer and industrial products, resulting in their widespread presence in the environment. Features such as environmental persistence, bioaccumulation, and high toxicity even at low doses have made PFASs an increasing concern. This brief review focuses on soil PFASs, especially the effect of soil PFASs on other environmental media and their potential threats to human health through daily diet. Specifically, soil PFASs contamination caused by different pathways was first investigated. Soil pollution from application of aqueous film-forming foams (AFFFs) is generally more severe than that from fluorochemical manufacturing plants, followed by biosolid land use, landfill, and irrigation. Factors, such as carbon chain length of PFASs, wastewater treatment technology, geographical conditions, and regional development level, are related to soil PFASs' pollution. Then, the migration, bioaccumulation, and toxicity characteristics of soil PFASs were analyzed. Short-chain PFASs have higher solubility, mobility, and bioavailability, while long-chain PFASs have higher bioaccumulation potential and are more toxic to organisms. Factors such as soil texture, solution chemistry conditions, enzymes, and fertilization conditions also influence the environmental behavior of PFASs. The risk of human exposure to PFASs through agricultural and animal products is difficult to control and varies depending on living region, age, eating habits, lifestyle, ethnicity, etc. Soil PFASs threaten drinking water safety, affect soil function, and enter food webs, threatening human health. Knowledge gaps and perspectives in these research fields are also included in current work to assist future research to effectively investigate and understand the environmental risks of soil PFASs, thereby reducing human exposure.

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“…This ubiquity leads to their accumulation in organisms. − Among the numerous PFAS, perfluorooctanesulfonate (PFOS) and perfluorooctanoic acid (PFOA) are the most common, while perfluorohexanesulfonate (PFHxS), perfluorobutyric acid (PFBS), undecafluorohexanoic acid (PFHxA), and heptafluorobutyric acid (PFBA) are frequently used substances. All six of these PFAS have been detected in the serum of pregnant women. − …”

Section: Introductionmentioning

confidence: 99%

Assessment and Comparison of Early Developmental Toxicity of Six Per- and Polyfluoroalkyl Substances with Human Embryonic Stem Cell Models

Zhao,

Yin,

Yang

et al. 2024

Environ. Sci. Technol.

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Per-and polyfluoroalkyl substances (PFAS) are extensively utilized in varieties of products and tend to accumulate in the human body including umbilical cord blood and embryos/ fetuses. In this study, we conducted an assessment and comparison of the potential early developmental toxicity of perfluorooctanoic acid (PFOA), undecafluorohexanoic acid (PFHxA), heptafluorobutyric acid, perfluorooctanesulfonate (PFOS), perfluorohexanesulfonate, and perfluorobutyric acid at noncytotoxic concentrations relevant to human exposure using models based on human embryonic stem cells in both three-dimensional embryoid body (EB) and monolayer differentiation configurations. All six compounds influenced the determination of cell fate by disrupting the expression of associated markers in both models and, in some instances, even led to alterations in the formation of cystic EBs. The expression of cilia-related gene IFT122 was significantly inhibited. Additionally, PFOS and PFOA inhibited ciliogenesis, while PFOA specifically reduced the cilia length. Transcriptome analysis revealed that PFOS altered 1054 genes and disrupted crucial signaling pathways such as WNT and TGF-β, which play integral roles in cilia transduction and are critical for early embryonic development. These results provide precise and comprehensive insights into the potential adverse health effects of these six PFAS compounds directly concerning early human embryonic development.

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Association between serum levels of TSH and free T4 and per- and polyfluoroalkyl compounds concentrations in pregnant women

Cited by 11 publications

References 49 publications

Characterization of Per- and Polyfluoroalkyl Substance (PFAS) concentrations in a community-based sample of infants from Samoa

Characterization of Per- and Polyfluoroalkyl Substance (PFAS) concentrations in a community-based sample of infants from Samoa

PFASs in Soil: How They Threaten Human Health through Multiple Pathways and Whether They Are Receiving Adequate Concern

Assessment and Comparison of Early Developmental Toxicity of Six Per- and Polyfluoroalkyl Substances with Human Embryonic Stem Cell Models

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