Association between Serum Klotho and Physical Frailty in Middle-Aged and Older Adults: Finding From the National Health and Nutrition Examination Survey

Guan, Zhongyang; Ma, Lina; Wu, Chenkai

doi:10.1016/j.jamda.2023.02.103

Cited by 9 publications

(5 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A systematic review of 16 studies highlights the inverse correlation between α-klotho and physical frailty [ 24 ]. Guan et al, in a cross-sectional study employing NHANES data from 2007 to 2016, corroborate this conclusion [ 25 ], aligning with Shardell et al's results [ 26 ]. Given that frailty, intricately intertwined with aging, manifests a soaring prevalence with advancing age, α-klotho, as a therapeutic target against accelerated aging [ 27 ], exhibits regulatory prowess over phosphate homeostasis [ 28 ], aging-related signaling pathways [ 29 ], oxidative stress reduction [ 30 ], and fibrosis protection [ 31 ].…”

Section: Discussionsupporting

confidence: 64%

See 1 more Smart Citation

Serum klotho levels and mortality patterns in frail individuals: unraveling the u-shaped association

Luo,

Zheng,

et al. 2024

Aging Clin Exp Res

View full text Add to dashboard Cite

Background Frailty, a clinical syndrome intricately linked with the aging process, stands as a harbinger of numerous adverse outcomes, most notably mortality. This study aimed to elucidate the association between serum α-klotho concentration and mortality patterns, including all-cause and cause-specific mortality, in patients with frailty. Methods The study employed Cox proportional hazard models, smoothed curve fitting, and supplementary analyses, encompassing threshold effect analysis, subgroup and sensitivity analyses, to explore the relationship between α-klotho levels and mortality, including all-cause, CVD, and cancer-related mortality. Results Among the 2,608 frail individuals (mean age: 60.78 [SD 10.48] years; 59.89% female), the mortality stood at 25.35% during a median follow-up period of 6.95 years. Both unadjusted and adjusted models revealed a significant inverse association between higher serum α-klotho levels and the risk of all-cause and CVD-related mortality ([mean(95% CI) 0.68 (0.55, 0.83)] for all-cause mortality; [mean(95% CI) 0.48 (0.32, 0.74)] for CVD-related mortality, all P for trend < 0.001). Notably, log2–klotho displayed a U-shaped correlation with all-cause mortality and cancer mortality, characterized by thresholds of 9.48 and 9.55, respectively. The robustness of these findings was consistently supported by subgroup and sensitivity analyses. Conclusion This study unveils a U shaped association between serum α-klotho levels and both all-cause and cancer-related mortality among middle-aged and elderly individuals with frailty in the United States. The identified serum α-klotho thresholds, at 714.8 pg/ml for all-cause mortality and 750.6 pg/ml for cancer-related mortality, hold promise as potential targets for interventions aimed at mitigating the risks of premature death and cancer within this vulnerable population.

show abstract

Section: Discussionsupporting

confidence: 64%

“…A systematic review of 16 studies highlights the inverse correlation between α-klotho and physical frailty [24]. Guan conclusion [25], aligning with Shardell et al's results [26].…”

Section: Discussionsupporting

confidence: 57%

Serum klotho levels and mortality patterns in frail individuals: unraveling the u-shaped association

Luo,

Zheng,

et al. 2024

Aging Clin Exp Res

View full text Add to dashboard Cite

show abstract

“…The multivariate logistic regression model was used to analyze the independent effects and multiplicative interaction between depression, smoking, and drinking based on initial model and adjusted model (adjusted for age, gender, ethnicity, education, household income and history of diabetes). We analyzed the interaction effect across different gender (male and female) and age groups (≤ 45 and > 45) [ 27 ]. Odds ratio (OR) and 95% confidence interval (CI) were calculated.…”

Section: Methodsmentioning

confidence: 99%

Independent and combined effects of smoking, drinking and depression on periodontal disease

Huang,

Xu,

Huang

et al. 2024

BMC Oral Health

View full text Add to dashboard Cite

Background Periodontitis is a complex chronic inflammatory disease that is particularly associated with health-related conditions such as smoking, excessive drinking and depression. This research aimed to investigate the interaction between these lifestyles factors on periodontitis risk. Methods This study included participants who participated in the National Health and Nutrition Examination Survey in the United States between 2009 and 2014. They had completed oral health-periodontal examination, Smoking-Cigarette Use Questionnaire, Alcohol Use Questionnaire, and Patient Health Questionnaire. Periodontal clinical attachment loss (CAL) of 3 mm or more and Patient Health Questionnaire-9 (PHQ-9) of 10 scores or more were used to identify periodontitis and depression, respectively. Daily alcohol consumption in the past year was classified into three levels: low (1 drink or less), moderate (between 1 and 3 drinks), and heavy drinking (4 drinks or more), while smoking was defined as having smoked at least 100 cigarettes in one's lifetime. Then, the logistic regression combined with interaction models were used to analyze the independent and combined effects of smoking, drinking and depression on periodontitis risk. Results The results indicated a statistically significant multiplicative interaction between smoking and depression in relation to the development of periodontitis, both in the overall population (P = 0.03) and among male participants (P = 0.03). Furthermore, among individuals experiencing depression, smoking was found to significantly increase the prevalence of periodontitis by 129% in the younger age group compared to non-smokers (odds ratio [OR]: 2.29; 95% confidence interval [CI]: 1.10 to 4.76). However, the interaction between smoking and alcohol consumption was only significant among females (P < 0.05). There was a dose-dependent relationship between drinking frequency and smoking on periodontitis prevalence. In the smoking population, occasional drinking (OR: 1.70; 95% CI: 1.22 to 2.37) and regular drinking (OR: 2.28; 95% CI: 1.68 to 3.11) significantly increased the prevalence of periodontitis compared to individuals without these two factors. Conclusion These results suggested that there were interactive effects between smoking, drinking and depression on periodontitis risk and policies aimed at healthy behaviours and mental health may be beneficial for our oral health.

show abstract

“…Based on previous studies, 19,23,28,29 clinical practice experience and the statistical significance, we gathered covariate data through questionnaires, physical examinations, and laboratory tests. The sociodemographic profile encompassed variables such as sex, age, race/ethnicity, marital status, educational level, family income, smoking habits, alcohol consumption, physical activity levels, and self-reported comorbidities.…”

Section: Covariatementioning

confidence: 99%

Association Between Serum Klotho and Chronic Obstructive Pulmonary Disease in US Middle-Aged and Older Individuals: A Cross-Sectional Study from NHANES 2013–2016

Shi,

Xu,

et al. 2024

COPD

View full text Add to dashboard Cite

This study sought to examine the potential association between serum Klotho levels and the prevalence of COPD in the United States. Patients and Methods: This study was a cross-sectional analysis involving 4361 adults aged 40-79 years participating in the US National Health and Nutrition Examination Survey (NHANES) conducted between 2013 and 2016. Our investigation utilized multivariate logistic regression and restricted cubic spline (RCS) regression to explore the potential correlation between serum Klotho concentrations and the prevalence of COPD. Additionally, we conducted stratified and interaction analyses to evaluate the consistency and potential modifiers of this relationship. Results: In this study encompassing 4631 patients (with an average age of 57.6 years, 47.5% of whom were male), 445 individuals (10.2%) were identified as having COPD. In the fully adjusted model, ln-transformed serum Klotho was negatively associated with COPD (OR = 0.71; 95% CI: 0.51-0.99; p = 0.043). Meanwhile, compared with quartile 1, serum Klotho levels in quartiles 2-4 yielded odds ratios (ORs) (95% CI) for COPD were 0.84 (0.63~1.11), 0.76 (0.56~1.02), 0.84 (0.62~1.13), respectively. A negative relationship was observed between the ln-transformed serum Klotho and occurrence of COPD (nonlinear: p = 0.140). the association between lntransformed serum Klotho and COPD were stable in stratified analyses. Conclusion: Serum Klotho was negatively associated with the incidence of COPD, when ln-transformed Klotho concentration increased by 1 unit, the risk of COPD was 29% lower.

show abstract

Association between Serum Klotho and Physical Frailty in Middle-Aged and Older Adults: Finding From the National Health and Nutrition Examination Survey

Cited by 9 publications

References 34 publications

Serum klotho levels and mortality patterns in frail individuals: unraveling the u-shaped association

Serum klotho levels and mortality patterns in frail individuals: unraveling the u-shaped association

Independent and combined effects of smoking, drinking and depression on periodontal disease

Association Between Serum Klotho and Chronic Obstructive Pulmonary Disease in US Middle-Aged and Older Individuals: A Cross-Sectional Study from NHANES 2013–2016

Contact Info

Product

Resources

About