Association between serum gamma-glutamyltransferase levels and hyperuricemia

Tekeli, Seçkin Özgür; Tekeli, Feyza; Eren, Esin; Yılmaz, Necat

doi:10.5455/annalsmedres.2020.02.152

Cited by 2 publications

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“…This enzyme is normally present in the serum and on the outer surface of numerous cell types (Baduwal et al, 2020; Dominici et al, 2005; Onat et al, 2012), and serum GGT is especially active in the proximal renal tubule, pancreas, and intestine, but primarily in the liver. Changes in serum GGT levels can be affected by all the following; waist circumference and body mass index (Sakamoto et al, 2013), hypertension (Bonnet et al, 2017; Celik et al, 2010; Cheung et al, 2011; Kunutsor, 2016), diabetes mellitus (Choi et al, 2020; Nguyen et al, 2011; Wang et al, 2020), hyperuricemia (Nakamura et al, 2012; Tekeli et al, 2021), metabolic syndrome (Franzini et al, 2017), and genetic factors (Paulusma et al, 2010). In addition, heritability estimates for GGT in adults range from 30% to 69% depending on gender and age (Pilia et al, 2006; Rahmioglu et al, 2009; van Beek et al, 2013; Whitfield et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Association betweenFTO(rs17817449) genetic variant, gamma‐glutamyl transferase, and hypertension in Slovak midlife women

Falbová

Vorobeľová

Siváková

et al. 2021

American J Hum Biol

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Objectives: This cross-sectional study investigates associations between the FTO rs 17817449 genetic variant, liver enzymes, and hypertension in Slovak midlife women. Methods: We assessed 576 Slovak women aged 39 to 65 years. The women were interviewed and examined during their medical examination at local Health Centers and then divided into subgroups according to their blood pressure status; 255 women with hypertension and 321 normotensive. The FTO genetic variant was detected by polymerase chain reaction-restriction fragment length polymorphism. Resultant data was analyzed by linear regression analysis and general linear models to adjust for risk factors associated with gammaglutamyl transferase levels (GGT), including waist to hip ratio (WHR) and uric acid (UA). Results: A significant association between the FTO variant and GGT levels was observed in the hypertensive group after control for confounding covariates, including WHR and UA (p = .004). The predicted GGT level for GT/TT hypertensive carriers is 0.158 μkat/L higher than for GG carriers. Moreover, the two-way analysis of covariance revealed significant interaction between FTO effects and hypertension on logGGT levels (p = .042). Finally, hypertensive women with the T-allele had the highest estimated marginal mean value of logGGT at À0.39 μkat/L while the GG-genotype in both hypertensive and normotensive women had the lowest value at À0.54 μkat/L.Conclusions: This study suggests that the FTO (rs17817449) variant is associated with higher serum GGT levels in hypertensive midlife women.

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Section: Introductionmentioning

confidence: 99%

Association betweenFTO(rs17817449) genetic variant, gamma‐glutamyl transferase, and hypertension in Slovak midlife women

Falbová

Vorobeľová

Siváková

et al. 2021

American J Hum Biol

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“…Compared to controls (group III), diabetic NAFLD (group I) had significantly elevated gamma-glutamyltransferase (GGT) (p0.001) and uric acid (p0.012). According to a study by Tekeli et al (22) , it confirmed the relationship between high serum GGT levels and hyperuricemia in T2DM and metabolic syndrome. Patients with diabetic NAFLD (group I) had a significantly lower serum albumin level (p=0.011) than controls (group III).…”

Section: Discussionmentioning

confidence: 80%

Diabetic and Non-Diabetic Non-Alcoholic Fatty Liver Disease Patients: Assessment Using Non-Invasive Diagnostic Tools

2024

The Egyptian Journal of Hospital Medicine

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Background: Non-alcoholic fatty liver disease (NAFLD) incidence is rapidly increasing. Objective: Our study aimed to assess diabetic and non-diabetic NAFLD using non-invasive imaging tools; conventional US, Chemical shift MRI, and MRE to evaluate the degree of liver steatosis and fibrosis. Patients and methods: In this case-control study, a total of 130 subjects including 90 NAFLD patients {50 diabetic (Group I) & 40 non-diabetic (Group II), as well as 40 controls (Group III) }, were enrolled. The mean age in the present study was 51.46 ± 7.54 years in group I, 48.40 ± 7.47 years in group II, and 49.55 ± 7.95 years in group III (controls). Most of our subjects were females (78%, 77.5%, and 65% in groups I, II, and III respectively). Assessment of liver steatosis was done using conventional US and chemical shift (in-phase and out-of-phase) MR imaging. Assessment of liver stiffness to detect the degree of fibrosis/cirrhosis was done using magnetic resonance enterography (MRE). Results: Diabetic NAFLD patients (group I) had a higher degree of liver steatosis (scores 2 and 3), measured by conventional US, compared to group II (non-diabetic NAFLD). Group I patients had a significantly higher degree of liver steatosis (p = 0.007), measured by chemical shift (in-phase and out-phase) MRI, compared to group II. Liver stiffness measurement by MRE was significantly higher (p = 0.038) in group I (Mean 2.88 ± 0.81 kPa) than in group II (mean 2.46 ± 0.71kPa). Liver fibrosis (≥ F2) was significantly higher (p = 0.021) in group 1 (20 of 50 patients (40%)) than in group II (7 of 40 patients (17.5%)). Conclusions: Current non-invasive imaging methods demonstrated their value as non-invasive imaging biomarkers to evaluate the degree of liver steatosis in NAFLD and its progression into fibrosis/cirrhosis.

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Association between serum gamma-glutamyltransferase levels and hyperuricemia

Cited by 2 publications

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Association betweenFTO(rs17817449) genetic variant, gamma‐glutamyl transferase, and hypertension in Slovak midlife women

Association betweenFTO(rs17817449) genetic variant, gamma‐glutamyl transferase, and hypertension in Slovak midlife women

Diabetic and Non-Diabetic Non-Alcoholic Fatty Liver Disease Patients: Assessment Using Non-Invasive Diagnostic Tools

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