Association between serum folate level and invasive cervical cancer at a university teaching hospital in South-West Nigeria

Sekumade, A; Okunade, Kehinde Sharafadeen; Olorunfemi, Gbenga; Daramola, Ebunoluwa O; Adenekan, Muisi A; Okunowo, Adeyemi Adebola; Anorlu, Rose

doi:10.4103/jcrp.jcrp_24_19

Cited by 2 publications

(2 citation statements)

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“…Glutathione provides a primary defence against oxidative stress by its ability to scavenge free radicals or participate in the reduction of hydrogen peroxide (H 2 O 2 ) and this is central to the detoxification of ROS [16]. Epidemiological studies have also demonstrated an association between antioxidants and cervical cancer [11,[17][18][19]; however, there is a paucity of studies on this subject in our environment. Moreover, the predominantly low socio-economic and poor nutritional factors could make these interactions different in our settings.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of oxidative markers in women with invasive cervical cancer in Lagos, Nigeria

Offor¹,

Okunade²,

Iwalokun³

et al. 2021

ecancer

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Epidemiological studies have showed that low levels of antioxidants induce the generation of free radicals leading to DNA damage and further mutations seen in cancer. This study evaluated the effects of oxidative markers on the occurrence and severity of cervical cancer at the Lagos University Teaching Hospital. This was an analytical crosssectional study carried out among women with histological diagnosis of invasive cervical cancer and their healthy cancer-free comparison group. Venous blood samples were collected from each participant for measurements of antioxidants (erythrocyte glutathione and vitamin C) and malondialdehyde (a marker of lipid peroxidation). Descriptive statistics were carried out for relevant demographic and clinical data. Associations between continuous variables were tested using the independent sample t-test or the analysis of variance for normally distributed data or the Mann-Whitney U test for skewed data, whereas categorical variables were compared using the χ 2 test. p < 0.05 was considered statistically significant. The mean level of malondialdehyde (MDA) was statistically higher in women with cervical cancer than in their cancer-free counterparts (p = 0.032). However, the mean glutathione (32.6 ± 6.2 versus 14.2 ± 6.1 mg/dL; p = 0.019) and vitamin C (12.4 ± 2.3 versus 14.6 ± 2.4 µmol/L; p = 0.001) levels were significantly lower in the case group compared to the cancer-free group. There are statistically increasing mean levels of MDA (p = 0.017) and decreasing mean levels of vitamin C (p = 0.004) with increasing stages of the disease. This study showed that women with cervical cancer have low levels of antioxidants and an increased level of the oxidative marker. The levels of these markers become more pronounced as the disease progresses. This will, therefore, form the basis for the conduct of future randomised controlled trials of antioxidant supplementations among cervical cancer patients in sub-Saharan Africa.

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Section: Introductionmentioning

confidence: 99%

Evaluation of oxidative markers in women with invasive cervical cancer in Lagos, Nigeria

Offor¹,

Okunade²,

Iwalokun³

et al. 2021

ecancer

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“…This is in line with the results of a study by Abebaw et al, (2022) which showed that women who used the latest contraception were 2.7 times more at risk of developing cervical cancer compared to women who did not use the latest contraception (aOR= 2.7; 95% CI= 1.56 to 7.45). Study by Sekumade et al (2019) which shows that women who use hormonal contraception are 5.51 times more at risk of developing cervical cancer compared to women who do not use hormonal contraception (aOR=5.51; 95% CI=2.85 to 8.31).…”

Section: Discussionmentioning

confidence: 99%

Meta-Analysis: Effects of Hormonal Contraceptive Use and History of Sexually Transmitted Disease on the Risk of Cervical Cancer

Damayanti,

Budihastuti,

Murti

2023

J Matern Child Health

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Background: Cervical cancer is a sexually transmitted disease (STD) with the fourth largest number of new cases and deaths worldwide. This study aimed to analyze the effects of the use of hormonal contraception and a history of STD on the risk of cervical cancer in women. Subjects and Method: The meta-analysis was carried out using the PRISMA flowchart and the PICO model. Population: women of reproductive age. Intervention: use of hormonal contraception and history of sexually transmitted infections Comparison: not using hormonal contraception and history of sexually transmitted infections Outcome: Cervical Cancer. The process of searching for articles is by searching through online journal databases which include Google Scholar, Elsevier and PubMed. With keywords “oral pill” OR “1 month injection” OR “3 month injection” OR “implant” OR “hormonal contraception” AND “cervical cancer” OR “syphilis” OR “chlamydia” OR “herpes” OR “gonorrhea” OR ”HIV” AND “Sexually transmitted infections” AND “Cross sectional” AND aOR. Articles were selected using the PRISMA flow and data analysis using the Review Manager 5.3 application. Results: This meta-analysis consisted of 12 articles from Africa and Asia . The total sample was 8,240. The use of hormonal contraception (aOR = 2.34; 95% CI= 1.83 to 4.66; p<0.001) and had history of STD (aOR = 1.97; 95% CI = 1.49 to 2.61; p<0.001) increased the risk of cervical cancer. Conclusion: The use of hormonal contraception and has history of std increase the risk of cervical cancer. Keywords: hormonal contraception, history of sexually transmitted infections, cervical cancer. Correspondence: Siti Damayanti. Master’s Program in Public Health, Universitas Sebelas Maret. Jl. Ir Sutami No.36, Kentingan, Jebres, Surakarta 57126, Central Java, Indonesia. Email: Sitidamayanti269@gmail.com.

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Association between serum folate level and invasive cervical cancer at a university teaching hospital in South-West Nigeria

Cited by 2 publications

References 12 publications

Evaluation of oxidative markers in women with invasive cervical cancer in Lagos, Nigeria

Evaluation of oxidative markers in women with invasive cervical cancer in Lagos, Nigeria

Meta-Analysis: Effects of Hormonal Contraceptive Use and History of Sexually Transmitted Disease on the Risk of Cervical Cancer

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