Association between serum estradiol level on the human chorionic gonadotrophin administration day and clinical outcome

Abstract

Background: Estradiol, as an important hormone in follicular development and endometrial receptivity, is closely related to clinical outcomes of fresh in vitro fertilization embryo transfer (IVF-ET) cycles. The aim of this retrospective study was to evaluate the association between elevated serum estradiol ( E 2 ) levels on the day of human chorionic gonadotrophin (hCG) administration and IVF-ET pregnancy and birth outcomes. Methods: A total of 1771 infertile patients with their first fresh IVF-ET cycles were analyzed retrospectively between January 2011 and January 2016 in Peking University First Hospital. Patients were categorized by serum E 2 levels on the day of hCG administration into six groups: group 1 (serum E 2 levels ≤ 1000 pg/mL, n = 205), group 2 (serum E 2 levels 1001–2000 pg/mL, n = 457), group 3 (serum E 2 levels 2001–3000 pg/mL, n = 425), group 4 (serum E 2 levels 3001–4000 pg/mL, n = 310), group 5 (serum E 2 levels 4001–5000 pg/mL, n = 237), and group 6 (serum E 2 levels > 5000 pg/mL, n = 137). The retrieved oocyte and MII oocyte numbers and implantation and clinical pregnancy rates of the groups were compared as the first objective of the study. For the 360 women with singleton births among all patients, the area under the corresponding receiver operating characteristic curve (ROC curve) was calculated to assess the predictive value of the E 2 change for the probability of low birth weight (LBW) infants as the second objective. Results: The retrieved oocyte and MII oocyte numbers and implantation and clinical pregnancy rates gradually increased from groups 1 to 5 but decreased in group 6. The parameters of group 1 were statistically worse than those of the other groups, from group 2 to group 6 (the number of retrieved oocytes, t = 13.096, t = 23.307, t = 23.086, t = 26.376, t = 19.636, P < 0.003; the number of retrieved MII oocytes, t = 10.856, t = 20.868, t = 21.874, t = 23.374, t = 19.092, P < 0.003; the implantation rate, χ 2 = 12.179, χ 2 =...

Estradiol on Trigger Day was Irrelevant to Live Birth Rates of Fresh Cycles but Positively Associated with Cumulative Live Birth Rates: A Multicenter Retrospective Study

“…The result indicated that ≥ 5000 pg/ml might comprise the pregnancy outcomes in fresh embryo transfer cycle, which was consistent with those in previous reports [15,25]. However, a single-center study of 3,393 fresh cycles revealed that the clinical live birth rate and live birth rate were higher in the high E2 groups (≥ 3,757 pg/ml).…”

Correlation between estradiol levels on day of HCG trigger and the number of mature follicles, number of oocytes retrieved, and the number of mature oocytes (M2) after oocyte aspiration in ICSI cycles

“…As estradiol increased, there was a significant increase in the number of follicles-NF (p < 0.001), number of oocytes retrieved-NRO (p < 0.001), and the number of mature oocytes-NMO (p < 0.001). Similar findings were noted in the study by Xin Li et al [12], where NRO, NMO, and CPR increased as E 2 level increased. But beyond a level of 5000 pg/ml, all these decreased.…”

Dual trigger protocol is an effective in vitro fertilization strategy in both normal and high responders without compromising pregnancy outcomes in fresh cycles

“…We do not routinely measure estradiol and progesterone levels during IVF cycles at the time of ovulation trigger; therefore, we cannot compare those between the study groups. Hormone levels may be a confounding factor that we did not investigate, because some studies have suggested that these levels affect IVF pregnancy outcomes in fresh cycles ( 35 , 36 , 37 ). Future studies should evaluate hormone serum levels in patients undergoing the dual trigger protocol to determine if estradiol or progesterone levels impact outcomes.…”