Association between serum copper-zinc ratio and respiratory tract infection in children and adolescents

Yang, Mei; Li, Yanshan; Yao, Chunlan; Wang, Yanzu; Yan, Caijin

doi:10.1371/journal.pone.0293836

Cited by 2 publications

(1 citation statement)

References 26 publications

(33 reference statements)

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“…ROS-induced oxidative stress plays a crucial role in the pathogenesis of many diseases, particularly chronic respiratory diseases, such as asthma, COPD, respiratory infections, lung cancer, and interstitial lung disease (Ramírez-Prieto et al, 2006;Park et al, 2009). Metals, such as Cu, have been identified as prooxidants and may accelerate the production of free radicals, leading to oxidative stress (Yang et al, 2023). The toxicity of excess Cu is mainly related to the production of reactive oxygen, which mediate the formation of ROS and ROS-induced damage to the organism at all levels (Jomova et al, 2022).…”

Section: Oxidative Stress and Antioxidant Capacity Of Cumentioning

confidence: 99%

Copper homeostasis dysregulation in respiratory diseases: a review of current knowledge

Song,

Yue,

Zhang

et al. 2024

Front. Physiol.

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Cu is an essential micronutrient for various physiological processes in almost all human cell types. Given the critical role of Cu in a wide range of cellular processes, the local concentrations of Cu and the cellular distribution of Cu transporter proteins in the lung are essential for maintaining a steady-state internal environment. Dysfunctional Cu metabolism or regulatory pathways can lead to an imbalance in Cu homeostasis in the lungs, affecting both acute and chronic pathological processes. Recent studies have identified a new form of Cu-dependent cell death called cuproptosis, which has generated renewed interest in the role of Cu homeostasis in diseases. Cuproptosis differs from other known cell death pathways. This occurs through the direct binding of Cu ions to lipoylated components of the tricarboxylic acid cycle during mitochondrial respiration, leading to the aggregation of lipoylated proteins and the subsequent downregulation of Fe-S cluster proteins, which causes toxic stress to the proteins and ultimately leads to cell death. Here, we discuss the impact of dysregulated Cu homeostasis on the pathogenesis of various respiratory diseases, including asthma, chronic obstructive pulmonary disease, idiopathic interstitial fibrosis, and lung cancer. We also discuss the therapeutic potential of targeting Cu. This study highlights the intricate interplay between copper, cellular processes, and respiratory health. Copper, while essential, must be carefully regulated to maintain the delicate balance between necessity and toxicity in living organisms. This review highlights the need to further investigate the precise mechanisms of copper interactions with infections and immune inflammation in the context of respiratory diseases and explore the potential of therapeutic strategies for copper, cuproptosis, and other related effects.

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Section: Oxidative Stress and Antioxidant Capacity Of Cumentioning

confidence: 99%

Copper homeostasis dysregulation in respiratory diseases: a review of current knowledge

Song,

Yue,

Zhang

et al. 2024

Front. Physiol.

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Association of Serum Zinc and Selenium Levels with Infection in Patients With Stroke

Majzoobi,

Javadi,

Hajilooi

et al. 2024

Epidemiol Health System J

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Background and aims: Patients with acute stroke are vulnerable to infectious diseases due to low consciousness, aspiration, dysphagia, and underlying conditions. Zinc and selenium play critical roles in boosting the immune system. This study aimed to compare serum zinc and selenium levels in patients with stroke before and after infection. Methods: The present prospective study was conducted on patients with stroke in Hamadan, west of Iran, from 2019 to 2020. Serum levels of zinc and selenium were measured before and after infection in patients with stroke. The calculated sample size for this study was 78 patients. A paired t-test was used to compare the mean zinc and selenium levels. The linear regression model was used to assess the association of clinical and para-clinical factors with the change in the serum level of selenium after infection. The level of statistical significance was 0.05. Results: The mean (±SD) age of participants was 71.33±14.27 years, and 55.1% of the participants were female. The mean (±SD) serum zinc levels before and after infection were 80.4±7.6 µg/dL and 74.3±7.9 µg/dL, respectively, indicating a significant difference (P<0.001). These values for selenium were 118.1±42.8 µg/dL and 78.4±29.4 µg/dL, respectively (P<0.001). There was a significant association between sepsis and decreases in the levels of selenium (-28.86 µg/dL, 95% CI: -56.13, -1.59) and zinc (-9.84 µg/dL, 95% CI: -16.12, -3.56). Conclusion: Based on our results, the levels of zinc and selenium in patients with stroke significantly decrease after infection compared to before infection.

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Association between serum copper-zinc ratio and respiratory tract infection in children and adolescents

Cited by 2 publications

References 26 publications

Copper homeostasis dysregulation in respiratory diseases: a review of current knowledge

Copper homeostasis dysregulation in respiratory diseases: a review of current knowledge

Association of Serum Zinc and Selenium Levels with Infection in Patients With Stroke

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