Association Between Serum Concentration of Apolipoproteins A-I and B with Gallbladder Disease

Morán, Segundo; Duque, Ximena; Salmerón, Jorge; Rodríguez-Leal, Gustavo Arturo; Martı́nez-Salgado, Homero; Uribe, Misael

doi:10.1016/s0188-4409(03)00025-0

Cited by 11 publications

(7 citation statements)

References 35 publications

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“…However high density lipoprotein was significantly lower in study group compared with control subjects. This finding was consistent with previous reports from different countries [26][27][28][29][30] while some could not find such relationship with gallbladder cancer 31,32 . The exact reason for this controversy was still unknown, but possibly it may be due to the differences in study populations, different ethnic group or region and different environmental factor.…”

Section: Discussionsupporting

confidence: 93%

Serum estrogen level and lipid profile in Gall stone and Gallbladder cancer: a case control study

Singh¹,

Dwivedi²,

Chandra³

et al. 2013

Int Jour of Biomed Res

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Section: Discussionsupporting

confidence: 93%

Serum estrogen level and lipid profile in Gall stone and Gallbladder cancer: a case control study

Singh¹,

Dwivedi²,

Chandra³

et al. 2013

Int Jour of Biomed Res

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“…Our findings are in agreement with previous cross-sectional and prospective studies of serum lipids and gallstones, which have consistently reported high triglycerides and low HDL in association with gallstone risk. [5][6][7]18,19 Paradoxical to the generally accepted association between hyperlipidemia and gallstones, we observed that lower levels of total cholesterol, LDL and apo B, characteristic of hypolipidemia, were also associated with biliary stones, independently of the other lipids and risk factors we examined. High levels of total cholesterol, LDL and apo B were not associated with biliary stones.…”

Section: Discussionmentioning

confidence: 99%

Serum lipid levels and the risk of biliary tract cancers and biliary stones: A population‐based study in China

Andreotti

Chen

Gao

et al. 2007

Intl Journal of Cancer

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Biliary tract cancers, encompassing the gallbladder, extrahepatic bile ducts and ampulla of Vater, are rare but highly fatal malignancies. Gallstones, the predominant risk factor for biliary cancers, are linked with hyperlipidemia. As part of a populationbased case-control study conducted in Shanghai, China, we examined the associations of serum lipid levels with biliary stones and cancers. We included 460 biliary cancer cases (264 gallbladder, 141 extrahepatic bile duct, and 55 ampulla of Vater), 981 biliary stone cases and 858 healthy individuals randomly selected from the population. Participants completed an in-person interview and gave overnight fasting blood samples. Participants in the highest quintile of triglycerides (≥160 mg/dl) had a 1.4-fold risk of biliary stones (95% CI 5 1.1-1.9), a 1.9-fold risk of gallbladder cancer (95% CI 5 1.3-2.8), and a 4.8-fold risk of bile duct cancer (95% CI 5 2.8-8.1), compared to the reference group (third quintile: 90-124 mg/dl). Participants in the lowest quintile of high-density lipoprotein (HDL) (<30 mg/dl) had a 4.2-fold risk of biliary stones (95% CI 5 3.0-6.0), an 11.6-fold risk of gallbladder cancer (95% CI 5 7.3-18.5), and a 16.8-fold risk of bile duct cancer (95% CI 5 9.1-30.9), relative to the reference group (third quintile: 40-49 mg/dl). In addition, total cholesterol, low-density lipoprotein (LDL) and apolipoprotein A (apo A) were inversely associated with biliary stones; whereas low levels as well as high levels of total cholesterol, LDL, apo A and apolipoprotein B (apo B) were associated with excess risks of biliary tract cancers. Our findings support a role for serum lipids in gallstone development and biliary carcinogenesis. ' 2007 Wiley-Liss, Inc.Key words: serum lipid levels; gallstones; biliary tract cancer Biliary tract cancers, consisting of tumors of the gallbladder, extrahepatic bile ducts and ampulla of Vater, are rare but highly fatal malignancies. 1,2 Gallstones are the most important known risk factor for all three biliary tract cancer subsites. Specifically, cholesterol gallstones (composed mainly of cholesterol) and mixed gallstones (composed of both cholesterol and bilirubin) are most strongly associated with gallbladder cancer. 2,3 Furthermore, cholesterol gallstones and gallbladder cancer share a number of putative risk factors, including obesity, high fat diet and hyperlipidemia. 2,4 Hyperlipidemia is generally characterized by high serum levels of total cholesterol, triglycerides, low-density-lipoprotein (LDL), and low levels of high-density-lipoprotein (HDL). High triglycerides and low HDL have been most consistently associated with gallstones, whereas the associations of total cholesterol and LDL with gallstones are less consistent. [5][6][7] Cholesterol gallstone pathogenesis involves cholesterol saturation of the bile duct due to the hypersecretion of cholesterol from the liver 8 ; however, the exact role of individual lipids, lipoproteins and apolipoproteins is less clear.Given the relationship between hyperlipidemia and gallsto...

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“…Furthermore, the presence of apo‐B‐100 gene Xba I polymorphysm associates with hypercholesterolemia and increased risk for cholesterol gallstones 55 . However, this issue is controversial because a large epidemiological survey shows an inverse association with GD 56 . Additional studies are therefore needed to assess the issue of apo‐B levels in GD both in the general population and, more specifically, in NAFLD patients.…”

Section: Discussionmentioning

confidence: 99%

Gallstone disease in non‐alcoholic fatty liver: Prevalence and associated factors

Loria¹,

Lonardo²,

Lombardini³

et al. 2005

J of Gastro and Hepatol

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Association Between Serum Concentration of Apolipoproteins A-I and B with Gallbladder Disease

Cited by 11 publications

References 35 publications

Serum estrogen level and lipid profile in Gall stone and Gallbladder cancer: a case control study

Serum estrogen level and lipid profile in Gall stone and Gallbladder cancer: a case control study

Serum lipid levels and the risk of biliary tract cancers and biliary stones: A population‐based study in China

Gallstone disease in non‐alcoholic fatty liver: Prevalence and associated factors

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