Association between Serum Cholesterol Level and Bone Mineral Density at Lumbar Spine and Femur Neck in Postmenopausal Korean Women

Abstract

BackgroundBlood lipid profiles have been suggested to be a risk factor for osteoporosis. However, the association between lipid profiles and bone mineral density (BMD) is still unclear. This study aimed to evaluate an association between blood lipid profiles and BMD through both a cross-sectional and a longitudinal study.MethodsStudy subjects were 958 postmenopausal Korean women who have repeatedly undertaken laboratory tests and BMD measurements at lumbar spine and femur neck with an interval of 7.1 years. The associations between lipid profiles and BMD were examined using Spearman correlation analysis with an adjustment for age, smoking, alcohol drinking, physical activity, body mass index, and follow-up duration.ResultsLumbar spine BMD was not associated with total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), and high density lipoprotein cholesterol (HLD-C) regardless of when the measurement was performed. In an analysis using data measured at the beginning of the study, femur neck BMD was not associated with TC and LDL-C. However, femur neck BMD showed weak but significantly positive correlation with HDL-C (correlation coefficient, 0.077; 95% confidence interval, 0.005 to 0.149). When the analysis was repeated with data measured at the end of the follow-up, there was no significant correlation between femur neck BMD and any lipid profile. In addition, change in femur neck BMD during follow-up was not associated with the change in lipid profiles.ConclusionAlthough further study with a consideration of calcium intake and osteoporosis medication seems necessary, this study found no association between serum lipid profiles and BMD in postmenopausal Korean women.

Association between nutritional screening via the Controlling Nutritional Status index and bone mineral density in chronic liver disease of various etiologies

“…Go et al . likewise found no significant variations in the spinal or femoral BMD as a result of changes in LDL cholesterol levels in 958 postmenopausal women after a follow‐up period of 7 years . In fact, Tanko et al .…”

Lipid Levels Related to Osteoporosis in Patients with Type 2 Diabetes

“…Some studies suggest that dyslipidemia could result in both increased bone resorption and decreased bone formation [1]. Various studies have tried to evaluate the association between lipid level and osteoporosis, but the results were proved to be controversial [1][2][3][4][5][6][7]. Some studies found an inverse relationship with bone mineral density (BMD) [1][2][3][4][5], whereas others have shown a positive correlation [6] or no correlation [7].…”

Serum Lipids Effect on Bone Mineral Density: A Pilot Study in Apparently Healthy Syrians

“…While some studies showed no effect of dislipidemia on BMD [27][28][29][30], others reported that there is either a negative [31][32][33][34][35] or a positive effect [36][37][38].…”

“…Whereas, Jeong-Ho Go et al in 2012 found no association between serum lipids and BMD in postmenopausal Korean women [28].…”