Association between serum carcinoembryonic antigen (CEA) levels and leukoaraiosis in middle-aged and older adults: A cross-sectional study

et al. 2020

Preprint

Purpose: Previous studies have shown that serum carcinoembryonic antigen (CEA) was independently associated with metabolic syndrome (MetS) risk. However, these studies were mainly cross-sectional analyses and cause has not been clarified. In the current study, we conducted two bidirectional cohort studies to investigate the bidirectional associations between CEA and MetS using a Chinese male sample cohort.Methods: The initial longitudinal cohort included 9,629 Chinese males from January 2010 to December 2015. Two bidirectional cohorts were conducted in the study: subcohort A (from CEA to MetS, n=6,439) included participants without MetS at baseline to estimate the risk of developing incident MetS; subcohort B (form MetS to CEA, n=8,533) included participants without elevated CEA level (Hyper-CEA) at baseline to examine the risk of developing incident Hyper-CEA. Hazard ratios were estimated using Cox proportional hazards models.Results: In subcohort A, the incidence densities of MetS were 85.47 and 99.25 per 1000 person-years with and without Hyper-CEA, respectively. Comparing without Hyper-CEA at baseline, participants with Hyper-CEA had a 0.89 (95% CI, 0.71 to 1.12)-fold hazard ratio of developing incidence MetS (P=0.326). In subcohort B, the incidence densities of Hyper-CEA were 33.42 and 29.13 per 1000 person-years for those with and without MetS, respectively. Participants with MetS had no significantly associated with incident Hyper-CEA (hazard ratio, 1.02; 95% CI, 0.84 to 1.22; P=0.864) in the general Chinese participants. Meanwhile, in the stratified analysis, MetS was might significantly associated with increased incident Hyper-CEA in men with age > 65-year and nonsmoking.Conclusion: CEA has no association with incident MetS. CEA should be interpreted carefully in MetS patients. Meanwhile, we need pay more attention to MetS in nonsmoking elderly men. They might have a higher risk of developing cancer.

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Bidirectional association between serum carcinoembryonic antigen and metabolic syndrome among Chinese male population: two cohort studies

et al. 2020

Preprint

“…Previous studies have shown that the index of CEA can increase the risk of many metabolic disorders using crosssectional designs [9,11,12,15,[19][20][21]. Moreover, a crosssectional study also found a positive association between CEA and MetS based on data from 2014 to 2015 (Supplemental Table S2), and it was consistent with previous studies [15,16].…”

Section: Discussionsupporting

confidence: 89%

Bidirectional association between serum carcinoembryonic antigen and metabolic syndrome among the Chinese male population: two cohort studies

et al. 2020

Lipids Health Dis

Purpose Previous studies have shown that serum carcinoembryonic antigen (CEA) is independently associated with metabolic syndrome (MetS). However, these studies were mainly cross-sectional analyses, and cause was not clarified. In the present study, two bidirectional cohort studies were conducted to investigate the bidirectional associations between CEA and MetS using a Chinese male sample cohort. Methods The initial longitudinal cohort included 9629 Chinese males enrolled from January 2010 to December 2015. Two bidirectional cohorts were conducted in the study: subcohort A (from CEA to MetS, n = 6439) included participants without MetS at baseline to estimate the risk of developing incident MetS; subcohort B (from MetS to CEA, n = 8533) included participants without an elevated CEA level (Hyper-CEA) at baseline to examine the risk of developing incident Hyper-CEA. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. Results In subcohort A, the incidence densities of MetS among participants with and without Hyper-CEA were 84.56 and 99.28 per 1000 person-years, respectively. No significant effects of Hyper-CEA on incident MetS were observed in subcohort A (HR, 0.89; 95% CI, 0.71 to 1.12; P = 0.326). In subcohort B, a higher incidence density of Hyper-CEA was found among participants with MetS (33.42 and 29.13 per 1000 person-years for those with and without MetS, respectively). For nonsmoking participants aged > 65 years, MetS increased the risk of incident Hyper-CEA (HR, 1.87; 95% CI, 1.09 to 3.20; P = 0.022). Conclusion For the direction of CEA on incident MetS, no significant association was observed. For the direction of MetS on incident Hyper-CEA, MetS in nonsmoking elderly men could increase the risk of incident Hyper-CEA, while this association was not found in other stratified participants. The clinical implications of the association between CEA and MetS should be interpreted with caution.

Section: Discussionmentioning

confidence: 90%

“…The level of CEA is signi cantly associated with various in ammatory markers, such as leucocyte count, CRP, and IL-6 levels. This is because CEA can bind to the CEA receptors on macrophages or monocytes and stimulate the production of pro-in ammatory cytokines [21,24].…”

Section: Discussionmentioning

confidence: 99%

Bidirectional association between serum carcinoembryonic antigen and metabolic syndrome among the Chinese male population: two cohort studies

et al. 2020

Preprint

Purpose: Previous studies have shown that serum carcinoembryonic antigen (CEA) is independently associated with metabolic syndrome (MetS). However, these studies were mainly cross-sectional analyses, and cause was not clarified. In the present study, two bidirectional cohort studies were conducted to investigate the bidirectional associations between CEA and MetS using a Chinese male sample cohort.Methods: The initial longitudinal cohort included 9,629 Chinese males enrolled from January 2010 to December 2015. Two bidirectional cohorts were conducted in the study: subcohort A (from CEA to MetS, n=6,439) included participants without MetS at baseline to estimate the risk of developing incident MetS; subcohort B (from MetS to CEA, n=8,533) included participants without an elevated CEA level (Hyper-CEA) at baseline to examine the risk of developing incident Hyper-CEA. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models.Results: In subcohort A, the incidence densities of MetS among participants with and without Hyper-CEA were 84.56 and 99.28 per 1000 person-years, respectively. No significant effects of Hyper-CEA on incident MetS were observed in subcohort A (HR, 0.89; 95% CI, 0.71 to 1.12; P=0.326). In subcohort B, a higher incidence density of Hyper-CEA was found among participants with Mets (33.42 and 29.13 per 1000 person-years for those with and without MetS, respectively). For nonsmoking participants aged > 65 years, MetS increased the risk of incident Hyper-CEA (HR, 1.87; 95% CI, 1.09 to 3.20; P=0.022).Conclusion: For the direction of CEA on incident MetS, no significant association was observed. For the direction of MetS on incident Hyper-CEA, MetS in nonsmoking elderly men could increase the risk of incident Hyper-CEA, while this association was not found in other stratified participants. The clinical implications of the association between CEA and MetS should be interpreted with caution.