Association between serum calcium and phosphorus concentrations with non‐alcoholic fatty liver disease in <scp>K</scp>orean population

Shin, Ju Young; Kim, Min Ji; Mo, Eun Young; Moon, Sung Dae; Han, Je Ho; Yeon, Bong

doi:10.1111/jgh.12832

Cited by 20 publications

(18 citation statements)

References 26 publications

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“…In addition, lean NAFLD patients also consumed higher levels of phosphorus, potassium, magnesium, and manganese than the control group. Previous study in human found that serum phosphorus levels were significantly associated with NAFLD (odds ratio: 1.36, 95% confidence interval: 1.26–1.47, P < 0.001) . However, most studies found that NAFLD patients had low consumption of potassium, magnesium, and manganese .…”

Section: Discussionmentioning

confidence: 96%

Lean non‐alcoholic fatty liver disease patients had comparable total caloric, carbohydrate, protein, fat, iron, sleep duration and overtime work as obese non‐alcoholic fatty liver disease patients

Guo

Okekunle

et al. 2018

J of Gastro and Hepatol

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Non-alcoholic fatty liver disease patients had higher total caloric, calorigenic nutrients, grain, potato, fruit, iron, and overtime work but shorter sleep duration. Lean NAFLD patients had comparable total caloric, calorigenic nutrients, iron, sleep duration, and overtime work as obese NAFLD patients. These features could be used to the nutritional education and therapeutic guidance for lean NAFLD patients in the future.

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Section: Discussionmentioning

confidence: 96%

Lean non‐alcoholic fatty liver disease patients had comparable total caloric, carbohydrate, protein, fat, iron, sleep duration and overtime work as obese non‐alcoholic fatty liver disease patients

Guo

Okekunle

et al. 2018

J of Gastro and Hepatol

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“…Despite this, multiple studies have failed to find a beneficial response to vitamin D supplementation in liver function or histology in patients with NAFLD [53,56,58]. Furthermore, vitamin D therapy is clinically limited due to its effect on calcium homeostasis and potential for hypercalcemia, a risk factor for NAFLD [53,60]. Vitamin A has not been studied extensively in patients with NAFLD, but like Vitamin D, a significant number of patients with NAFLD have been noted to have vitamin A deficiency [61,62].…”

Section: Role Of Other Vitamins Minerals and Emerging Strategiesmentioning

confidence: 99%

“…However, studies are lacking. Cross-sectional analyses have noted that calcium, phosphorus, and sodium intake have been associated with increased rates of NAFLD while magnesium has been inversely related with NAFLD [60,63,64]. In animal studies, reduction in AST and ALT in mice with NAFLD was noted following zinc and selenium co-supplementation [65,66].…”

Section: Role Of Other Vitamins Minerals and Emerging Strategiesmentioning

confidence: 99%

The Role of Vitamin E in the Treatment of NAFLD

Perumpail

John

et al. 2018

Diseases

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There has been a growing interest in the role of vitamin E supplementation in the treatment and/or prevention of nonalcoholic fatty liver (NAFLD). We performed a systematic review of the medical literature from inception through 15 June 2018 by utilizing PubMed and searching for key terms such as NAFLD, vitamin E, alpha-tocopherol, and nonalcoholic steatohepatitis (NASH). Data from studies and medical literature focusing on the role of vitamin E therapy in patients with NAFLD and nonalcoholic steatohepatitis (NASH) were reviewed. Most studies assessing the impact of vitamin E in NAFLD were designed to evaluate patients with NASH with documented biochemical and histological abnormalities. These studies demonstrated improvement in biochemical profiles, with a decline in or normalization of liver enzymes. Furthermore, histological assessment showed favorable outcomes in lobular inflammation and hepatic steatosis following treatment with vitamin E. Current guidelines regarding the use of vitamin E in the setting of NAFLD recommend that vitamin E-based treatment be restricted to biopsy-proven nondiabetic patients with NASH only. However, some concerns have been raised regarding the use of vitamin E in patients with NASH due to its adverse effects profile and lack of significant improvement in hepatic fibrosis. In conclusion, the antioxidant, anti-inflammatory, and anti-apoptotic properties of vitamin E accompanied by ease-of-use and exceptional tolerability have made vitamin E a pragmatic therapeutic choice in non-diabetic patients with histologic evidence of NASH. Future clinical trials with study design to assess vitamin E in combination with other anti-fibrotic agents may yield an additive or synergistic therapeutic effect.

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“…Evidence on the role of phosphorous intake and NAFLD development remains limited. Although animal studies have demonstrated an association between low phosphorous intake and insulin resistance (72), and between altered glucose (73) and cholesterol metabolism in rats (74), contrary to these findings, human studies have shown an association between higher serum phosphorous levels and NAFLD (75), and between CVD risk factors and events (76,77). Further studies examining the role of phosphorus and selenium in liver health are warranted.…”

Section: Discussionmentioning

confidence: 99%

Cross-sectional analysis of the health profile and dietary intake of a sample of Canadian adults diagnosed with non-alcoholic fatty liver disease

Aktary

Eller

Nicolucci

et al. 2020

Food & Nutrition Research

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Background: Dietary intake is an important factor in the development and management of non-alcoholic fatty liver disease (NAFLD); however, optimal dietary composition remains unclear. Moreover, there is minimal evidence on the relationship between dietary intake and markers of liver health in Canadian adults diagnosed with NAFLD. Objective: The aim of this study is to characterize the dietary intake of a sample of Canadian adults diagnosed with NAFLD and examine the correlations with markers of liver health. Design: Forty-two adults recruited from the community and hepatology clinics in Calgary, Canada from 2016 to 2019 completed a 3-day food record. Anthropometrics, blood biomarkers, liver stiffness (FibroScan), and liver fat (magnetic resonance imaging) were measured. Nutrient intake was compared with the data from the 2004 and 2015 Canadian Community Health Surveys. Relationships were assessed using Pearson's correlation and regression analysis. Results: Relative to Canadian dietary recommendations, participants consumed lower magnesium, fiber, calcium, vitamin D, and vitamin E, and higher cholesterol, saturated fat, total fat, fructose, iron, vitamin B12, selenium, phosphorus, and sodium. Compared with the national average, participants consumed more energy, fiber, sodium, total fat, and saturated fat. Systolic blood pressure (P = 0.012), serum α-2 macroglobulin (P = 0.008), carbohydrate (P = 0.022), total fat (P = 0.029), and saturated fat intakes (P = 0.029) were associated with FibroScan scores. Liver fat was correlated with serum triglycerides (P < 0.001), trunk fat (P = 0.029), added sugar (P = 0.042), phosphorus (P = 0.017), and magnesium intake (P = 0.013). In females, selenium intake was associated with liver fat (P = 0.015) and FibroScan score (P = 0.05), while in males, liver fat was associated with trunk fat (P = 0.004), body weight (P = 0.004), high-density lipoprotein (P < 0.001), and fructose intake (P = 0.037). Regression analysis showed that increasing magnesium intake corresponds to a decrease in liver fat. Conclusion: Despite the higher energy intake of participants, overall nutrient intake is low, suggesting lower diet quality. Associations between select micronutrients and liver health markers warrant further investigation.

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Association between serum calcium and phosphorus concentrations with non‐alcoholic fatty liver disease in Korean population

Abstract: Serum calcium and phosphorus levels are significantly associated with NAFLD. Further investigation is needed to verify whether calcium and phosphorus levels indicate a higher risk of NAFLD.

Cited by 20 publications

References 26 publications

Lean non‐alcoholic fatty liver disease patients had comparable total caloric, carbohydrate, protein, fat, iron, sleep duration and overtime work as obese non‐alcoholic fatty liver disease patients

Lean non‐alcoholic fatty liver disease patients had comparable total caloric, carbohydrate, protein, fat, iron, sleep duration and overtime work as obese non‐alcoholic fatty liver disease patients

The Role of Vitamin E in the Treatment of NAFLD

Cross-sectional analysis of the health profile and dietary intake of a sample of Canadian adults diagnosed with non-alcoholic fatty liver disease

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