Association between serum alkaline phosphatase and C-reactive protein in the United States National Health and Nutrition Examination Survey 2005–2006

Abstract

ALP is a marker of cardiometabolic risk, but it needs to be tested as part of a multivariate model in prospective studies.

Alkaline Phosphatase, Serum Phosphate, and Incident Cardiovascular Disease and Total Mortality in Older Men

“…17,18 ALP has shown to be associated with CRP in this and other studies. 20 ALP levels may, therefore, partially reflect inflammation of hepatic origin because CRP is hepatically derived. In vascular disease, atherosclerosis is associated with inflammatory processes (reflected in raised CRP levels), and in advanced atherosclerotic plaque there is calcification and increased expression of ALP.…”

“…In vascular disease, atherosclerosis is associated with inflammatory processes (reflected in raised CRP levels), and in advanced atherosclerotic plaque there is calcification and increased expression of ALP. 20 Thus, inflammation may be a common link between ALP and CHD. Because proinflammatory cytokine is known to stimulate release of vWF from vascular endothelium, this may explain the association between ALP and endothelial dysfunction, although other pathways may be clearly involved.…”

“…3 In the few population studies which have investigated the association between ALP and CVD, elevated ALP is associated with increased CVD mortality and hospitalization. [17][18][19] ALP has been shown to be strongly associated with C-reactive protein (CRP), the definitive marker of inflammation 20 ; however, whether the ALP-CVD relationship is independent of inflammation has not been well studied. Moreover, there is a paucity of data on mineral metabolism and CVD risk in older people.…”

Histopathological and Enzymatic Changes in Liver of Mice Treated with Tricyclazole

“…We also found that TCZ injection reduced the level of ALP, which is a biochemical marker for bone and liverbiliary disorders as well as lapidated liver (15,16). Some studies reported that triazoles reduce ALP levels (6,12), while others claimed the opposite (17,18). The reduced level of ALP may be caused by bile duct hyperplasia observed in histopathological examination of our TCZ-treated samples.…”

Serum alkaline phosphatase and high sensitivity C-reactive protein in type II diabetes mellitus: a risk of cardio vascular disease in South Indian population

“…These measurements are complementary: the patient's glucose measurements provide a picture of short-term glycemic control, whereas HbA1c reflects average glycemic control over the previous 3 months. 11 In a recently published literature-based Meta-analysis of studies assessing the associations of liver enzymes and CVD risk in participants recruited from approximately general populations, the results suggested a modest positive linear association between ALP activity and CVD risk. 12 The purpose of study was to investigate a possible correlation between raised ALP levels in type 2 diabetics and non-diabetics.…”