Association between serum albumin to serum creatinine ratio and mortality risk in patients with heart failure

Abstract

The aim of this study was to investigate the association between serum albumin to serum creatinine ratio (sACR) and the prognosis of HF. In this single‐center prospective cohort study, a total of 2625 HF patients were enrolled between March 2012 and June 2017. All patients were divided into three groups according to the tertiles of sACR. Of 2625 patients, the mean age was 57.0±14.3. During a median follow‐up time of 23 months, 666 end point events occurred. Prognosis analysis indicated that the lowest sACR ratio was significantly associated with higher mortality risk of HF (HR= 1.920, 95% CI=1.585‐2.326; P< 0.001) when compared with the highest tertile. After adjusting for covariates including age, gender, diabetes, SBP, DBP, heart rate, total cholesterol, triglycerides, HDL‐C, LDL‐C, white blood cell count, hemoglobin, glycosylated hemoglobin and β‐blocer use, the HRs for mortality risk of HF was 1.513 (95% CI= 1.070‐2.139; P = 0.019). Subgroup analysis indicated that the mortality risk of HF statistically significantly reduced with the rise in sACR ratio in patients with no β‐blocker use, patients with serum creatine <97 μmol/L. However, stratification by age, sex, history of hypertension, diabetes and smoking, level of glycosylated hemoglobin and albumin have no obvious effect on the association between sACR ratio and the prognosis of HF. Additionally, patients with lower sACR displayed reduced left ventricular ejection fraction and increased left ventricular end‐diastolic diameter. The discriminant power of sACR alone and in combination with age, gender, SBP, heart rate and glycosylated hemoglobin were excellent with C statistic of 0.655 and 0.889, respectively. Lower sACR ratio was an independent risk factor for mortality risk of HF.

Association between serum albumin creatinine ratio and all-cause mortality in intensive care unit patients with heart failure

“…Recent research findings have been similar to ours, indicating that low sACR was an independent risk factor for mortality in heart failure patients ( 7 ). Nevertheless, different from this study, our study focused on heart failure patients with more severe conditions.…”

“…Serum creatinine, a product of renal metabolism, serves as a significant marker for renal function impairment, Renal dysfunction is a frequent comorbidity in heart failure patients and is strongly associated with adverse outcomes in individuals with acute heart failure ( 6 ). Furthermore, renal function influences serum albumin levels, and the serum albumin to serum creatinine ratio (sACR) has been identified as a novel biomarker ( 7 ). Given the complex interplay between heart failure, systemic inflammation, and renal dysfunction, integrating serum albumin and creatinine into sACR may offer a more comprehensive assessment of the pathophysiological alterations in heart failure, thus enhancing prognostic accuracy.…”