Association between serum 25‐hydroxyvitamin D and the effects of Angiotensin II receptor blocker on renal function among African Americans: A post hoc analysis of a randomized placebo‐controlled trial

Abstract

Angiotensin II (Ang II) is a vasoconstrictive hormone that plays a critical role in renal sodium handling and has been implicated as being one of the major contributors to salt-dependent hypertension. 1 Angiotensin II receptor blocker (ARB) is recommended as one of the major treatments of hypertension. ARBs inhibit the actions of Ang II through selective binding of type 1 (AT 1) receptors in vascular smooth muscle 2 and are effective in lowering blood pressure (BP), preventing major cardiovascular outcomes. 3 However, ARB is shown to be less effective in lowering BP in African Americans than their white counterparts in multiple clinical trials and observational