Association between serotonin transporter gene polymorphism and anxiety-related traits

Katsuragi, Satomi; Sano, Akira; Tsutsumi, Takashi; Isogawa, Koichi; Nanko, Shinichiro; Akiyoshi, Jotaro

doi:10.1016/s0006-3223(98)00090-0

Cited by 183 publications

(97 citation statements)

References 11 publications

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“…Lesch et al 4 originally reported an association in United States subjects between the short form of the polymorphism and higher scores on the Neuroticism scale of Costa and McRae's NEO-PI-R 5 and with higher estimated scores for Cloninger's Tridimensional Personality Questionnaire 6 (TPQ) scale of harm avoidance. These findings were supported by a study 7 of older United States subjects using the actual TPQ instrument and by two Japanese studies, one using the TPQ 8 and the other using a self-report anxiety and depression questionnaire. 9 Another study, in Finnish subjects, found linkage but not association of the 5-HTTLPR with facets of harm avoidance.…”

mentioning

confidence: 59%

Association and linkage of anxiety-related traits with a functional polymorphism of the serotonin transporter gene regulatory region in Israeli sibling pairs

2000

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A functional polymorphism in the regulatory region of the serotonin transporter gene (5-HTTLPR) has been reported to be both associated and linked to anxietyrelated personality measures, although other studies have not replicated these findings. The current study examines both association and linkage of the gene to two major anxiety-related personality measures, the harm avoidance scale on the Tridimensional Personality Questionnaire and the neuroticism scale of the NEO-PI-R, in a sample of 148 Israeli subjects comprising 74 same-sex sibling pairs. We replicated the reported association between the short allele and higher scores on the TPQ harm avoidance scale (P = 0.03), including the subscale of shyness (P = 0.02), and also found association in the same direction between the short allele and the NEO-PI-R neuroticism subscales of anxiety (P = 0.03) and depression (P = 0.04). Sib-pair linkage analysis, using the regression method, further supported a role of the 5-HTTLPR in anxiety-related personality traits. Molecular Psychiatry (2000) 5, 216-219.

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mentioning

confidence: 59%

Association and linkage of anxiety-related traits with a functional polymorphism of the serotonin transporter gene regulatory region in Israeli sibling pairs

2000

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“…Since this original report, others have confirmed the association between the 5-HTTLPR short allele and heightened anxiety (Du, Bakish, & Hrdina, 2000;Katsuragi et al, 1999;Mazzanti et al, 1998;Melke et al, 2001;Munafo, Clark, & Flint, 2005;Schinka, Busch, & Robichaux-Keene, 2004;Sen, Burmeister, & Ghosh, 2004) and have also demonstrated that individuals possessing the short allele more readily acquire conditioned fear responses (Garpenstrand, Annas, Ekblom, Oreland, & Fredrikson, 2001) and develop affective illness (Lesch & Mössner, 1998), in comparison with individuals homozygous for the long allele. Infants homozygous for the S allele have similar increases in anxiety-related measures (Auerbach, Faroy, Ebstein, Kahana, & Levine, 2001;Auerbach et al, 1999).…”

Section: Serotonin-transporter Genetic Variation and Individual Diffementioning

confidence: 85%

Neuroimaging studies of serotonin gene polymorphisms: Exploring the interplay of genes, brain, and behavior

Brown

Hariri

2006

Cognitive, Affective, & Behavioral Neuroscience

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Because of the unique ability it provides to investigate information processing at the level of neural systems, functional neuroimaging is a powerful tool to explore the relationship between genes, brain, and behavior. Recently, functional neuroimaging has provided dramatic illustrations of how a promoter polymorphism in the human serotonin transporter gene, which has been weakly related to several dimensions of emotional behaviors (such as neuroticism and anxiety traits), is strongly related to the engagement of neural systems-namely, the amygdala and subgenual prefrontal cortex, subserving emotional information processing. This review will outline the experimental strategy by which these genetic effects on brain function have been explored and highlight the effectiveness of this strategy to delineate biological pathways and mechanisms contributing to the emergence of individual differences in brain function that potentially bias behavior and risk for psychiatric illness.

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“…The results of the meta-analysis do not support the conclusion that might be drawn by simply counting the number of studies reporting significant results. It should be stressed, however, that there were certain limitations in the present study; there were insufficient data points (ie individual studies) to allow a one-way ANOVA across three genotype groups, so only two groups could be compared in the analysis, unlike in some individual studies 68 where individual data allowed this. We also did not investigate genetic associations with facets of personality subscales.…”

Section: Genetic Polymorphisms and Personality Mr Munafò Et Almentioning

confidence: 95%

Genetic Polymorphisms and Personality in Healthy Adults: A systematic review and meta-analysis

et al. 2003

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A meta-analysis was conducted on studies reporting data on associations between candidate genes and human personality. Studies reporting data for psychiatric populations (including organic disease and substance abuse) were excluded. A total of 46 studies contributed to the analysis. Pooled data using a fixed-effects model suggested significant associations between the 5HTT LPR, DRD4 c4t, DRD4 length, DRD2 A1/A2, DRD3 A1/A2 polymorphisms and personality traits. A multivariate analysis using a mixed-effects model and including age, sex and predominant ethnicity as covariates was applied to the analyses of 5HTT LPR and DRD4 length polymorphism data. Only the association between the 5HTT LPR polymorphism and avoidance traits remained significant (P ¼ 0.038). However, sensitivity analyses excluding data from studies reporting allele frequencies not in Hardy-Weinberg equilibrium and unpublished data resulted in this association no longer being significant. Implications for the design of future association studies of human personality are discussed, including the likely sample sizes that will be required to achieve sufficient power and the potential role of moderating variables such as sex.

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Association between serotonin transporter gene polymorphism and anxiety-related traits

Cited by 183 publications

References 11 publications

Association and linkage of anxiety-related traits with a functional polymorphism of the serotonin transporter gene regulatory region in Israeli sibling pairs

Association and linkage of anxiety-related traits with a functional polymorphism of the serotonin transporter gene regulatory region in Israeli sibling pairs

Neuroimaging studies of serotonin gene polymorphisms: Exploring the interplay of genes, brain, and behavior

Genetic Polymorphisms and Personality in Healthy Adults: A systematic review and meta-analysis

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