Association between seropositivity to <i>Chlamydia pneumoniae</i> and acute ischaemic stroke

Madre, J. Gil; García, J L; Gonzalez, Rosbel; Montero, Jessica; Paniagua, Enrique Botia; Escribano, Joaquin; Martinez, J. Dominguez; Cenjor, R. Fernandez

doi:10.1046/j.1468-1331.2002.00408.x

Cited by 43 publications

(39 citation statements)

References 17 publications

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“…Many case-control studies 8,9,12,13,25,26 have demonstrated an association between antibodies against C pneumoniae (mainly IgA) and stroke in other populations. Some seroepidemiological studies have also reported an association between past C pneumoniae infection and asymptomatic carotid atherosclerosis, [27][28][29][30] although this finding has not been consistent.…”

Section: Discussionmentioning

confidence: 99%

Chronic Chlamydia pneumoniae Infection and Stroke in Cameroon

Njamnshi

Blackett²,

Mbuagbaw³

et al. 2006

Stroke

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Section: Discussionmentioning

confidence: 99%

Chronic Chlamydia pneumoniae Infection and Stroke in Cameroon

Njamnshi

Blackett²,

Mbuagbaw³

et al. 2006

Stroke

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“…Infection of the vascular wall with Cp has been linked to ischemic heart disease (2-5) and stroke (6)(7)(8)(9)(10)(11)(12) in epidemiological studies and in pathological studies using immunocytochemistry, polymerase chain reaction (PCR) and electron microscopy. In Japan, Miyashita et al (13) reported a significant elevation of Cp antibody level in an acute myocardial infarction patient and Kawamotoet al (14) showed a significant relation between atherosclerotic lesions and common carotid arteries.…”

Section: Introductionmentioning

confidence: 99%

An Association between an Antibody against Chlamydia pneumoniae and Ischemic Stroke in Elderly Japanese

et al. 2003

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Objective Chlamydia pneumoniae (Cp) is an important pathogen for infections of the respiratory tract; recently, also a numberof reports suggesting its relation to atherosclerosis. This study was performed to clarify the relation between Cp infection and ischemic stroke. Patients Forty elderly patients with ischemic stroke (age 75±6.6; male 57.5%) and 85 elderly control subjects without a history of ischemic stroke (age 74±8.1; male 43.5 %) were investigated. Methods Patients were divided into four groups according to clinical diagnosis: 1) atherothrombotic infarction, 2) lacunar infarction, 3) those with cardiac embolism, and 4) non-classifiable. Cp infection was determined by measuring the anti-Q; IgG specific antibody level (Cp positive. Cp seropositiveness, as adjusted by multiple regression analysis using various knownrisk factors, was a significant independent contributing factor for ischemic stroke (p=0.017) and was associated with an increased risk for atherothrombotic infarction (odds ratio, 12.6; 95% CI, 2.0-79.3). Conclusion This suggests that Cp infection is also animportant risk factor for ischemic stroke, particularly atherothrombotic infarction in elderly Japanese. (Internal Medicine 42: 571-575, 2003)

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“…Retrospective and cross-sectional studies have suggested that both bacterial and viral infections may be risk factors for atherosclerosis, ischemic stroke and acute coronary events (7)(8)(9)(10)(11). Some studies do not confirm the association between seropositivity to C. pneumoniae and increased risk of cardiovascular diseases in populations with stroke (12). Although, the role of C. pneumoniae infection has been seriously considered in patients with myocardial infarction as a new atherothrombotic risk factor, but in acute ischemic stroke there are few data to support the eventual association (13).…”

Section: Introductionmentioning

confidence: 99%

The Association Between Chlamydia pneumoniae Infection and Ischemic Stroke

Eini¹,

Keramat²,

Farajpoor³

2014

Avicenna J Clin Microbiol Infect

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Background: Chlamydia pneumoniae has been linked with increased risk of cardiovascular diseases; however, data on stroke and cerebrovascular accidents are sparse. Objectives: The aim of this study was to determine the association between C. pneumoniae infection and ischemic stroke. Patients and Methods:In a case-control study, 141 patients, admitted with ischemic stroke, were compared with gender and age-matched control subjects (n = 141). Using an enzyme-linked immunosorbent assay kit, the presence of C. pneumoniae IgG and IgA in the patients' sera was determined. The data were analyzed by SPSS software (version 15) and were compared between the two groups using T-test and chi square test. Results: The mean ages of the case and control groups were 68.97 ± 12.29 and 66.95 ± 6.68 years old, respectively. The difference between these two groups was not statistically significant (P = 0.102). The seroprevalence of C. pneumoniae-specific IgG were 78.7% in the patients with stroke and 52.5% in the control group. The difference between the two groups was statistically significant (P = 0.0001). The seroprevalence of C. pneumoniae-specific IgA were 41.1% in the stroke and 15.6% in the control group. The difference between the two groups was statistically significant (P = 0.0001). Conclusions:The results supported the hypothesis that serological evidence of C. pneumoniae infection may be associated with an increased risk of ischemic stroke and cerebrovascular accident.

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Association between seropositivity to Chlamydia pneumoniae and acute ischaemic stroke

Cited by 43 publications

References 17 publications

Chronic Chlamydia pneumoniae Infection and Stroke in Cameroon

Chronic Chlamydia pneumoniae Infection and Stroke in Cameroon

An Association between an Antibody against Chlamydia pneumoniae and Ischemic Stroke in Elderly Japanese

The Association Between Chlamydia pneumoniae Infection and Ischemic Stroke

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