Association Between Self-Reported Polycystic Ovary Syndrome with Chronic Diseases Among Emiratis: A Cross-Sectional Analysis from the UAE Healthy Future Study

Juber, Nirmin F.; Abdulle, Abdishakur; AlJunaibi, Abdulla; Alnaeemi, Abdulla; Ahmad, Amar; Leinberger-Jabari, Andrea; Dhaheri, Ayesha S. Al; AlZaabi, Eiman; Al-Maskari, Fatma; Anouti, Fatme Al; Alsafar, Habiba; Alkaabi, Juma; Wareth, Laila Abdel; Aljaber, Mai; Kazim, Marina; Weitzman, Michael; Al-Houqani, Mohammad; Hag-Ali, Mohammed; Oumeziane, Naima; Sherman, Scott E.; Shah, Syed M.; Almahmeed, Wael; Idaghdour, Youssef; Loney, Tom; El-Shahawy, Omar; Ali, Raghib

doi:10.2147/ijwh.s398651

Cited by 4 publications

(5 citation statements)

References 30 publications

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“…Our study does not support the hypothesis of a higher prevalence of PCOS in the UAE compared to other regions of the world, despite anecdotal reports and some previous publications [23,25], which had inferred a higher prevalence of PCOS in the UAE compared to other regions of the world. However, the increased estimated prevalence of PCOS, from 1.19% in 2020 to 2.72% in 2022, is concerning and warrants long term surveillance.…”

Section: Discussioncontrasting

confidence: 99%

“…These previously published studies on the prevalence of PCOS using ICD codes reported a prevalence that ranged from 0.3% to 2.6%, which was not too different from the 1.6% prevalence found in our research. However, the prevalence of PCOS in our study was lower when compared to published studies that used the Rotterdam criteria (0.7% [20] to 33.5% [21]), the NIH criteria (3.6% [20] to 15.3% [22]) or self-reported diagnosis (25.9% [23]).…”

Section: Discussioncontrasting

confidence: 94%

“…Regarding the UAE, prior research on the prevalence of PCOS utilized subjective criteria, such as self-reported diagnosis [10,23,24], or ultrasound criteria alone [11] to determine the prevalence of PCOS, which ranged from 13% [10] to 25.9% [23]. Therefore, our research, which relied on ICD codes to diagnose PCOS, is an important addition to the literature on the prevalence of PCOS in the UAE.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of Polycystic Ovary Syndrome amongst Females Aged between 15 and 45 Years at a Major Women’s Hospital in Dubai, United Arab Emirates

Mirza

Tahlak

Hazari

et al. 2023

IJERPH

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Objective criteria have been scarce in published data on the occurrence of polycystic ovary syndrome (PCOS) in the United Arab Emirates (UAE). It is crucial that we enhance our comprehension of PCOS prevalence in the UAE to inform key stakeholders about the disease’s burden and enable comparisons with other nations. This research aimed to examine the PCOS prevalence at a large academic tertiary centre in Dubai, UAE, called Latifa Women and Children’s Hospital. We performed a cross-sectional study by reviewing the electronic medical records of patients accessing care between 2017 and 2022 (5 years). By utilizing the international classification of diseases codes (ICD-10), we discovered a period prevalence of PCOS of 1.6% among 64,722 women aged between 15 and 45 years. It is worth noting that the estimated annual point prevalence rose from 1.19% in 2020 (at the beginning of the COVID19 pandemic) to 2.72% in 2022 (after the start of the COVID-19 pandemic). Therefore, the odds ratio of the risk of a PCOS diagnosis in 2022 compared to 2020 was 2.28. The majority of the women diagnosed with PCOS in this study had an ICD-10 code of E28.2. Women with PCOS were younger than the controls, less likely to be pregnant, and had a higher body mass index and systolic and diastolic blood pressure. This is the most extensive research to date examining PCOS prevalence in the UAE, and it emphasizes the significance of this condition. It is crucial to prioritize PCOS to prevent morbidity and mortality from reproductive and long-term health consequences, including infertility, type 2 diabetes and endometrial cancer, which is presently the most frequent gynecological cancer in the UAE.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

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Prevalence of Polycystic Ovary Syndrome amongst Females Aged between 15 and 45 Years at a Major Women’s Hospital in Dubai, United Arab Emirates

Mirza

Tahlak

Hazari

et al. 2023

IJERPH

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“…However, our study provided a new perspective on how asthma and PCOS might be linked in the opposite direction. Our recent bi-directional study examining asthma and PCOS found a significant association between asthma diagnosed at <25 years and adult PCOS diagnosed at ≥25 years, independent of age and BMI ( 30 ). Female hormonal disturbance, metabolic syndrome, and obesity have been suggested as overlapping mechanisms that link asthma and PCOS ( 11 – 14 , 31 ).…”

Section: Discussionmentioning

confidence: 99%

“…Previous epidemiological studies have also found an association between PCOS and subsequent asthma ( 13 , 29 ). However, there is a limited epidemiological study on another possible direction of the association between asthma and subsequent PCOS, including our previous work examining the association between asthma diagnosed at <25 years with subsequent PCOS diagnosed at ≥25 years ( 30 ). Asthma may be associated with subsequent PCOS as asthma and PCOS are multifactorial complex diseases and they shared pathophysiological mechanisms, including female hormonal disturbance, systemic/low-grade inflammation, as well as obesity and, metabolic syndrome ( 11 – 14 , 31 ).…”

Section: Introductionmentioning

confidence: 99%

Association between pediatric asthma and adult polycystic ovarian syndrome (PCOS): a cross-sectional analysis of the UAE healthy future Study (UAEHFS)

et al. 2023

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IntroductionAsthma and polycystic ovarian syndrome (PCOS) are linked in several possible ways. To date, there has been no study evaluating whether pediatric asthma is an independent risk factor for adult PCOS. Our study aimed to examine the association between pediatric asthma (diagnosed at 0-19 years) and adult PCOS (diagnosed at ≥20 years). We further assessed whether the aforementioned association differed in two phenotypes of adult PCOS which were diagnosed at 20-25 years (young adult PCOS), and at >25 years (older adult PCOS). We also evaluated whether the age of asthma diagnosis (0-10 vs 11-19 years) modified the association between pediatric asthma and adult PCOS.Material and methodsThis is a retrospective cross-sectional analysis using the United Arab Emirates Healthy Future Study (UAEHFS) collected from February 2016 to April 2022 involving 1334 Emirati females aged 18-49 years. We fitted a Poisson regression model to estimate the risk ratio (RR) and its 95% confidence interval (95% CI) to assess the association between pediatric asthma and adult PCOS adjusting for age, urbanicity at birth, and parental smoking at birth.ResultsAfter adjusting for confounding factors and comparing to non-asthmatic counterparts, we found that females with pediatric asthma had a statistically significant association with adult PCOS diagnosed at ≥20 years (RR=1.56, 95% CI: 1.02-2.41), with a stronger magnitude of the association found in the older adult PCOS phenotype diagnosed at >25 years (RR=2.06, 95% CI: 1.16-3.65). Further, we also found females reported thinner childhood body size had a two-fold to three-fold increased risk of adult PCOS diagnosed at ≥20 years in main analysis and stratified analyses by age of asthma and PCOS diagnoses (RR=2.06, 95% CI: 1.08-3.93 in main analysis; RR=2.74, 95% CI: 1.22-6.15 among those diagnosed with PCOS > 25 years; and RR=3.50, 95% CI: 1.38-8.43 among those diagnosed with asthma at 11-19 years).ConclusionsPediatric asthma was found to be an independent risk factor for adult PCOS. More targeted surveillance for those at risk of adult PCOS among pediatric asthmatics may prevent or delay PCOS in this at-risk group. Future studies with robust longitudinal designs aimed to elucidate the exact mechanism between pediatric asthma and PCOS are warranted.

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The Association Between Obesity and Polycystic Ovary Syndrome: An Epidemiologic Study of Observational Data

Amiri,

Hatoum,

Hopkins

et al. 2024

The Journal of Clinical Endocrinology &Amp; Metabolism

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Background Polycystic Ovary Syndrome (PCOS) is a common female cardio-metabolic-reproductive disorder. It is unclear whether the global obesity epidemic is impacting the high PCOS prevalence. Objective To determine the extent to which obesity contributes to the PCOS development globally. Materials and methods A systematic review was conducted to identify population studies on PCOS prevalence globally, through July 2023. Linear regression and random-effect models were applied to examine the association of mean body mass index (BMI) or obesity prevalence with the prevalence of PCOS diagnosed by 1990 National Institute of Health (NIH), 2003 Rotterdam (Rotterdam), and 2006 Androgen Excess-PCOS (AE-PCOS) criteria. Subgroup analyses were also conducted for recruitment methods and study quality. Results Fifty-eight studies with 85,956 adults from 24 countries were included. Considering all available data, a borderline association was observed between PCOS and obesity prevalence when using the AE-PCOS, but not the NIH or Rotterdam criteria. Alternatively, subgroup analysis of studies with better recruitment methods demonstrated a significant positive association of population mean BMI or obesity prevalence with PCOS prevalence when using the Rotterdam or AE-PCOS criteria, while using only high-quality studies revealed an association using NIH as well as Rotterdam and AE-PCOS criteria. Overall, we observed that a 1% increase in obesity prevalence resulted in an approximately 0.4% increase in PCOS prevalence by the Rotterdam criteria. Conclusions These data indicate that obesity increases the development of PCOS, although the effect is modest. Our data also emphasizes the need to undertake only high-quality studies in assessing PCOS epidemiology

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Association Between Self-Reported Polycystic Ovary Syndrome with Chronic Diseases Among Emiratis: A Cross-Sectional Analysis from the UAE Healthy Future Study

Cited by 4 publications

References 30 publications

Prevalence of Polycystic Ovary Syndrome amongst Females Aged between 15 and 45 Years at a Major Women’s Hospital in Dubai, United Arab Emirates

Prevalence of Polycystic Ovary Syndrome amongst Females Aged between 15 and 45 Years at a Major Women’s Hospital in Dubai, United Arab Emirates

Association between pediatric asthma and adult polycystic ovarian syndrome (PCOS): a cross-sectional analysis of the UAE healthy future Study (UAEHFS)

The Association Between Obesity and Polycystic Ovary Syndrome: An Epidemiologic Study of Observational Data

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