Association between secondary thrombocytosis and viral respiratory tract infections in children

Abstract

Secondary thrombocytosis (ST) is frequently observed in children with a variety of clinical conditions. The leading cause of ST is respiratory tract infection (RTI) in children. Nasopharyngeal aspirate samples were collected and assessed for common respiratory viruses. The relationships between virus infections and secondary thrombocytosis were analyzed retrospectively. The blood platelet count and the presence of respiratory viruses were determined for 3156 RTI patients, and 817 (25.9%) cases with platelet ≥500 × 109/L were considered as the thrombocytosis group. Compared with the normal group, the detection rates of respiratory syncytial virus (RSV) and human rhinovirus (HRV) were significantly higher in the thrombocytosis group (P = 0.017 and 0.042, respectively). HRV single infection was a risk factor associated with thrombocytosis [odds ratio (OR) = 1.560, 95% confidence interval (CI) = 1.108–2.197]. Furthermore, ST was more likely to occur in younger patients who had clinical manifestations of wheezing and dyspnea and who had been diagnosed with bronchiolitis. Furthermore, the course of disease lasted longer in these patients. ST is associated with viral respiratory tract infections, especially RSV and HRV infections. HRV single infection is a risk factor associated with thrombocytosis.

Thrombocytosis in 715 Dogs (2011–2015)

“…There is no current consensus in human or veterinary clinical pathology as to the most appropriate cutoff for classifying a thrombocytosis. Large retrospective studies and reviews of thrombocytosis in the human medical field have utilized a cutoff of >450–500 × 10 3 /μL to define a thrombocytosis, but a cutoff of >800 × 10 3 /μL to signify clinically relevant thrombocytosis . For the present study, the cutoff value of >500 × 10 3 /μL was extrapolated from past studies to establish disease correlation with higher platelet counts, as the clinical relevance of severity is unknown and investigating this was one of the objectives of the study.…”

Trombositoz saptanan çocuklarda klinik ve hematolojik profilin değerlendirilmesi

“…Çalışmalarda çocuklarda sekonder trombositozların en sık nedeni olarak enfeksiyonlar bildirilmiş olup bizim çalışmamızda da aynı sonuca ulaşılmıştır. Solunum yolu enfeksiyonlarında trombositoza sık rastlanırken literatürde gastrointestinal ve üriner sistem enfeksiyonları da dikkat çekicidir [7].…”

The implications of platelet count changes during hospitalization in the disease management of pediatric patients with bronchiolitis

“…The delta platelet count of 50 × 10 9 /L was determined as the cut-off value for the three groups to minimize the chance of misclassification of patients according to known normal variability of platelet counts measured by the counter (XE2000i, Sysmex, Japan) [15][16][17]. Thrombocytosis was defined as a platelet count > 500 × 10 9 /L, according to the relevant studies [9,11]. Fever was defined as an axillary temperature exceeding 38.0 °C.…”

“…Previous studies on pediatric patients with bronchiolitis have focused on single platelet count determinations at hospital admission, and these studies found that the prevalence of thrombocytosis on admission ranged from 22.7% to 38.6% among consecutive patients with bronchiolitis [9][10][11]. The association between thrombocytosis on admission and disease severity in patients with bronchiolitis has been studied [9].…”

“…However, the average life span of platelets in blood is 7-10 days. Therefore, during the hospitalization of patients with bronchiolitis, the platelet count may change significantly within the period as a result of altered production and increased destruction and/or sequestration of thrombocytes [7,8,11,12]. To date, the clinical implications of platelet count changes in patients with bronchiolitis throughout hospitalization have not been extensively investigated.…”