Association between MAPK and PI3K/Akt signaling pathway‐related gene polymorphisms and migraine
Mingxue Wang,
Yujia Gu,
Shuhan Meng
et al.
Abstract:BackgroundThe causes of migraine remain unclear. Evidence suggests that the MAPK and PI3K/Akt signaling pathways play a role in migraine pathogenesis. However, studies on genetic polymorphisms in the two pathways associated with migraine are still limited.MethodsThis study included 226 migraineurs and 452 age‐ and sex‐matched nonmigraine control individuals. Genotyping of 31 Single Nucleotide Polymorphisms (SNPs) in 21 genes was performed. The relationship between migraine and gene polymorphisms was analyzed b… Show more
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