Association between sarcopenia and oral functions in community‐dwelling older adults: A cross‐sectional study

Kugimiya, Yoshihiro; Iwasaki, Masanori; Ohara, Yuki; Motokawa, Köiti; Edahiro, Ayako; Shirobe, Maki; Watanabe, Yutaka; Taniguchi, Yu; Seino, Satoshi; Abe, Takumi; Obuchi, Shuichi; Kawai, Hisashi; Kera, Takeshi; Fujiwara, Yoshinori; Kitamura, Akihiko; Ihara, Kazushige; Kim, Hunkyung; Shinkai, Shoji; Hirano, Hirohiko

doi:10.1002/jcsm.13145

Cited by 9 publications

(3 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, there were no statistically significant associations of the serum Cr/CysC ratio with occlusal force or masticatory function (Table 4), although a previous study has shown an association of sarcopenia with occlusal force and masticatory function 31 . However, in the current study, a lower number of remaining teeth was significantly correlated with low occlusal force and low masticatory function: OR, 0.48 (95% CI, 0.31–0.70) for low occlusal force, and 0.69 (95% CI, 0.48–0.96) for low masticatory function per five increments of teeth (Table 4).…”

Section: Discussioncontrasting

confidence: 83%

Decreased serum creatinine to cystatin C ratio is associated with low tongue pressure

Komorita,

Ide,

Yoshinari

et al. 2023

Geriatrics Gerontology Int

View full text Add to dashboard Cite

AimTongue strength plays an important role in the process of food intake, and low tongue pressure has been associated with aspiration pneumonia, cognitive decline, and mortality. However, special equipment for tongue pressure measurement is uncommon in general practice. Recently, the serum creatinine‐to‐cystatin C (Cr/CysC) ratio has been validated as a marker of muscle volume mass. Thus, we aimed to investigate the association of the serum Cr/CysC ratio with tongue pressure in a cross‐sectional study.MethodsThis single‐center, cross‐sectional study enrolled 73 participants (mean age, 71.7 years; men, 49.3%) who regularly attended the hospital for treatment of chronic disease. A tongue pressure of <30 kPa was defined as low tongue pressure. We evaluated the relationships between the serum Cr/CysC ratio and tongue pressure using multiple regression analysis.ResultsThe serum Cr/CysC ratio was correlated with tongue pressure (R2 = 0.25, P < 0.0001). In multiple regression analyses adjusted for confounders including age, sex, body mass index, and serum albumin, the association remained significant (P = 0.0001). In logistic analyses, the multivariable‐adjusted odds ratios of the Cr/CysC ratio for tertiles 1 and 2 compared with tertile 3 for low tongue pressure were 7.81 (95% confidence interval, 1.45–51.73) and 2.71 (95% confidence interval, 0.60–13.19), respectively.ConclusionsWe demonstrated that a decreased serum Cr/CysC ratio was associated with a higher risk of low tongue pressure. Our findings suggest that this simple serum surrogate marker may be a first step toward an intervention for oral function by general practitioners. Geriatr Gerontol Int 2024; 24: 102–108.

show abstract

Section: Discussioncontrasting

confidence: 83%

Decreased serum creatinine to cystatin C ratio is associated with low tongue pressure

Komorita,

Ide,

Yoshinari

et al. 2023

Geriatrics Gerontology Int

View full text Add to dashboard Cite

show abstract

“…Recently, Kugimiya et al reported that multiple aspects of oral functions including occlusal force, tongue-lip motor function, tongue pressure, masticatory function, and swallowing function were low among community-dwelling older adults with sarcopenia [ 50 ]. The group with a high OFI score and at high risk for oral frailty was found to have low grip strength, low muscle strength, and muscle mass, as reflected by the low values of cystatin C-related indices in the high-risk oral frailty group.…”

Section: Discussionmentioning

confidence: 99%

Association between oral frailty and cystatin C-related indices—A questionnaire (OFI-8) study in general internal medicine practice

et al. 2023

View full text Add to dashboard Cite

Background Cystatin C-related indices such as the ratio of creatinine to cystatin C (Cr/CysC) and the ratio of estimated glomerular filtration rate by cystatin C (eGFRcys) to creatinine eGFRcre (eGFRcys/eGFRcre) levels have been shown to be associated with muscle mass and strength and can be markers of sarcopenia. Oral frailty is defined as an age-related gradual loss of oral functions, accompanied by a decline in cognitive and physical functions. It results in adverse health-related outcomes in older age, including mortality, physical frailty, functional disability, poor quality of life, and increased hospitalization and falls. Therefore, poor oral health among the elderly is an important health concern due to its association with the pathogenesis of systemic frailty, suggesting it to be a multidimensional geriatric syndrome. The Oral Frailty Index-8 (OFI-8) is a questionnaire that can be used for easy screening of oral frailty. This study aimed to investigate whether cystatin C- related indices are different between patients with low to moderate risk of oral frailty and those at high risk of oral frailty, using the OFI-8 in attending a general internal medicine outpatient clinic. Materials and methods This is a cross-sectional study that included 251 patients with a mean age of 77.7±6.6 years and a median age of 77 years (128 men: mean age, 77.1±7.3 years; median age, 77 years and 123 women: mean age, 78.4±5.7 years; median age, 78 years) attending general internal medicine outpatient clinics. OFI-8 scores were tabulated by gender to determine whether there were differences between patients at low to moderate risk of oral frailty (OFI-8 score ≤3 points) and those at high risk (OFI-8 score ≥4 points) in Cr/CysC, eGFRcys/eGFRcre levels, height, weight, grip strength, etc. were examined. Results The OFI-8 score was higher in women than in men, suggesting that oral frailty is more common in women. Cr/CysC, eGFRcys/eGFRcre and grip strength were significantly lower in both men and women in the high-risk group for oral frailty (OFI-8 score ≥ 4). Height, hemoglobin level, red blood cell count, and serum albumin levels were significantly lower in men with an OFI-8 score ≥4. Receiver operating characteristic curve (ROC) analysis also showed that Cr/CysC and eGFRcys/eGFRcre were significantly associated with an OFI-8 score≥4 in both men and women. Conclusion Cr/CysC and eGFRcys/eGFRcre were significantly lower in the high-risk group for oral frailty on the OFI-8in both men and women. A relationship exists among cystatin C-related indices, which can effectively screen systemic frailty. Similarly, the OFI-8 score can be used to effectively screen oral frailty. Thus, a collaboration that incorporates both systemic and oral frailty from medical and dental perspectives is required.

show abstract

“…meat, fruit, and vegetables 31 , 32 . Thus, elderly subjects with impaired mastication are at higher risk of developing malnutrition and consequent sarcopenia due to low uptake of proteins and other essential nutrients 10 .…”

Section: Discussionmentioning

confidence: 99%

Feasibility of using cross-sectional area of masticatory muscles to predict sarcopenia in healthy aging subjects

Janović,

Miličić,

Antić

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Determination of sarcopenia is crucial in identifying patients at high risk of adverse health outcomes. Recent studies reported a significant decline in masticatory muscle (MM) function in patients with sarcopenia. This study aimed to analyze the cross-sectional area (CSA) of MMs on computed tomography (CT) images and to explore their potential to predict sarcopenia. The study included 149 adult subjects retrospectively (59 males, 90 females, mean age 57.4 ± 14.8 years) who underwent head and neck CT examination for diagnostic purposes. Sarcopenia was diagnosed on CT by measuring CSA of neck muscles at the C3 vertebral level and estimating skeletal muscle index. CSA of MMs (temporal, masseter, medial pterygoid, and lateral pterygoid) were measured bilaterally on reference CT slices. Sarcopenia was diagnosed in 67 (45%) patients. Univariate logistic regression analysis demonstrated a significant association between CSA of all MMs and sarcopenia. In the multivariate logistic regression model, only masseter CSA, lateral pterygoid CSA, age, and gender were marked as predictors of sarcopenia. These parameters were combined in a regression equation, which showed excellent sensitivity and specificity in predicting sarcopenia. The masseter and lateral pterygoid CSA can be used to predict sarcopenia in healthy aging subjects with a high accuracy.

show abstract

Association between sarcopenia and oral functions in community‐dwelling older adults: A cross‐sectional study

Cited by 9 publications

References 44 publications

Decreased serum creatinine to cystatin C ratio is associated with low tongue pressure

Decreased serum creatinine to cystatin C ratio is associated with low tongue pressure

Association between oral frailty and cystatin C-related indices—A questionnaire (OFI-8) study in general internal medicine practice

Feasibility of using cross-sectional area of masticatory muscles to predict sarcopenia in healthy aging subjects

Contact Info

Product

Resources

About