Association Between Sarcomeric Variants in Hypertrophic Cardiomyopathy and Myocardial Oxygenation: Insights From a Novel Oxygen-Sensitive Cardiovascular Magnetic Resonance Approach

12 Cardiovascular magnetic resonance has a significant role in the management of acute heart failure admissions: a tertiary referral service experience

“…1,2 Daniel J Hammersley, 3 Hassan A Zaidi, 1,2 Richard E Jones, 2 Suzan Hatipoglu, 2 Emmanuel Androulakis, 1,2 Lukas Mach, 1,2 Amrit S Lota, 1,2 Upasana Tayal, 1,2 Zohya Khalique, 1,2 Antonio De Marvao, 2 Resham Baruah, 4 Kaushik Guha, 1,2 Dudley J Pennell, 1,2 Brian P Halliday, 3⌽ Martin J Bishop, 1,2⌽ Sanjay K Prasad. 1 Introduction Greater precision is required for arrhythmic risk stratification of patients with non-ischaemic cardiomyopathy (NICM).…”

“…1,2 Daniel J Hammersley, 3 Hassan A Zaidi, 1,2 Richard E Jones, 2 Suzan Hatipoglu, 2 Emmanuel Androulakis, 1,2 Lukas Mach, 1,2 Amrit S Lota, 1,2 Upasana Tayal, 1,2 Zohya Khalique, 1,2 Antonio De Marvao, 2 Resham Baruah, 4 Kaushik Guha, 1,2 Dudley J Pennell, 1,2 Brian P Halliday, 3⌽ Martin J Bishop, 1,2⌽ Sanjay K Prasad. 1 Introduction Greater precision is required for arrhythmic risk stratification of patients with non-ischaemic cardiomyopathy (NICM). We sought to evaluate whether fibrosis entropy,a measure of scar texture heterogeneity derived from late gadolinium enhancement cardiovascular magnetic resonance (LGE-CMR), had incremental utility to fibrosis presence for arrhythmic risk prediction in NICM.…”

“…1 Jian L Yeo, 1 Gaurav S Gulsin, 1 Abhishek Dattani, 1 Anna-Marie Marsh, Introduction Type 2 diabetes (T2D) confers 10% higher relative risk of heart failure in women than men, 1 which may be linked to higher prevalence of coronary microvascular dysfunction. We aimed to determine the prevalence and sex-specific determinants of coronary microvascular dysfunction in asymptomatic people with T2D.…”

10 Impaired stress myocardial oxygenation precedes contractile abnormalities in three models of cardiac hypertrophy: insights from a novel oxygen sensitive cardiac magnetic resonance approach

“…myocardial perfusion reserve (MPR) estimates consistent with, and interchangeable across studies and preferably with PET, which remains the gold-standard [1]. There lack of inter-vendor standardisation remains an important hinderance for the implementation of QP CMR into routine clinical practice.…”

“…Fast low flip angle short (FLASH) normalised blood-oxygen level-dependent cardiovascular magnetic resonance (nBOLD CMR) is a novel oxygen-sensitive CMR approach which allows for precise measurement of myocardial oxygenation. 1 We sought to a) characterise myocardial oxygenation in three models of hypertrophy: geneticnon-obstructive hypertrophic cardiomyopathy (nHCM); metabolic -Type 2 diabetes (T2DM); structuralsevere Aortic Stenosis (SevAS) using nBOLD CMR and b) evaluate its potential for detecting oxygenation impairment in relation to contractile and perfusion abnormalities. Materials and Methods 113 participants including healthy controls (n=30), T2DM (n=29), nHCM (n=29), and severe AS (n=24) underwent cine, adenosine stress nBOLD CMR, first pass perfusion imaging and late gadolinium (LGE) CMR.…”