Association between risk factors of metabolic syndrome with lung function

Lee, Yi-Yen; Tsao, Yu-Chung; Yang, Chih‐Kai; Chuang, Chung-Hsun; Yu, Wei; Chen, Jih-Chang; Li, Wencheng

doi:10.1038/s41430-018-0369-6

Cited by 21 publications

(20 citation statements)

References 34 publications

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“…When each metabolic component was used to independently predict FVC (% predicted value), FEV1 (% predicted value), and the FEV1/FVC ratio, the result was consistent with that of previous studies [ 14 , 21 , 22 ]: after adjusting for age and family income group, WC was one of the MS components related to FVC and FEV1 reduction among men. To date, central obesity (abdominal obesity) is considered to be a common cause of metabolic and cardiovascular diseases in adults, including hyperglycemia, hypertension, and dyslipidemia.…”

Section: Discussionsupporting

confidence: 87%

High-Density Lipoprotein Cholesterol: A Component of the Metabolic Syndrome with a New Role in Lung Function

Wang

Tian

Zhao

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. A considerable uncertainty exists about the relationship between adult metabolic syndrome (MS) and obstructive lung disease (OLD), perhaps owing to systemic inflammation. Therefore, this study aimed to investigate the relationship between MS (with its components) and the patterns of lung function impairment. Methods. The participants in this study were 3978 adults aged 30-78 years from the baseline cohort of the Ningxia Cohort Study. The participants underwent pulmonary function tests, questionnaire surveys, physical examinations, and analysis of blood specimens. Results. No significant difference in the prevalence of OLD was observed between male (15.9%) and female (14.2%) participants. After adjusting for possible confounding factors (e.g., age and family income), impaired lung function was found to be related to some MS components, such as abdominal obesity, high blood pressure, and low levels of high-density lipoprotein cholesterol (HDL-C) (all P < 0.05 ). Conclusions. As an important component of MS, abdominal obesity is related to impaired lung function. Surprisingly, this study found that increased HDL-C levels could accelerate the decline of lung function; it also suggests that in the presence of different metabolic health conditions, especially abdominal obesity and low levels of HDL-C, various metabolic indicators should be comprehensively considered to prevent the decline of lung function. This partly explains the increase in the incidence of two or more chronic diseases. Therefore, the prevention of chronic diseases should shift from single-disease prevention to a comprehensive consideration of multi-disease prevention in the future. Therefore, a more sensitive evaluation of the role of HDL-C in lung function is warranted.

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Section: Discussionsupporting

confidence: 87%

High-Density Lipoprotein Cholesterol: A Component of the Metabolic Syndrome with a New Role in Lung Function

Wang

Tian

Zhao

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…When we independently predicted FVC, FEV1 and FEV1/FVC ratio for each metabolic component, we found that after adjusting for age and family income group, WC was one of the MetS components associated with the decrease of FVC and FEV1 in males. This was consistent with some studies [13,20,21]. At present, it was believed that central obesity (abdominal obesity) was the source of common metabolic diseases and cardiovascular diseases in adults, such as hyperglycemia, hypertension, dyslipidemia and so on, and was the core component of MetS [22].…”

Section: Discussionsupporting

confidence: 90%

Association Between Metabolic Syndrome and Lung Function in Rural Areas in China

Wang¹,

Tian²,

Zhao³

et al. 2020

Preprint

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Background There remains considerable uncertainty about the association between adult metabolic syndrome (MetS) and obstructive lung disease (OLD) possibly through generalized systemic inflammation. The purpose of this study was to investigate the relationship between MetS and its components and lung function patterns. Methods Participants (n = 3978) were drawn from Pingluo and Qingtongxia residents at baseline from the Ningxia Cohort Study. The MetS was assessed according to the criteria of National Cholesterol Education Program III. Spirometric parameters were measured to define lung function. Through multiple linear regression and logistic regression analysis, these relationships were tested. Results The prevalence of obstructive lung disease (OLD) was comparable between genders (15.9% and 14.2%). The prevalence of obstructive pulmonary disease (OLD) was comparable between genders (15.9% and 14.2%), but the prevalence of MetS in males with co-existent OLD was lower than that in females (32.9% and 40.8%). After adjusting for potential confounders such as age and family income group, impaired lung function was associated with individual components of the metabolic syndrome, such as abdominal obesity, hypertension, and low HDL -C(all parameters were p < 0.05). Conclusions As an important component of MetS, abdominal obesity is associated with impaired lung function. Surprisingly, there is a negative correlation between HDL-C and lung function, and the presence of this relationship suggests a new understanding of the role of HDL-C.

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“…The most enriched terms for adipocytes included waist-hip ratio, cholesterol, inflammatory traits, and birthweight, whereas the most enriched terms for preadipocytes included atrial fibrillation and inflammatory traits. We also observed enrichments for traits with less apparent, but established connections to cardiometabolic traits, including forced expiratory volume, a measure of lung function that has been shown to be lower in individuals with metabolic syndrome and high body fat percentage [41,42], and intraocular pressure, which has been shown to be higher in individuals with metabolic syndrome and markers of obesity [43,44]. Taken together, we found that peaks in adipocytes contribute more to heritability of WHRadjBMI, whereas preadipocytes may contribute more to heritability of CAD, though to a lesser degree.…”

Section: Trait Heritability Enrichment Within Context-dependent Peaksmentioning

confidence: 72%

Chromatin accessibility and gene expression during adipocyte differentiation identify context-dependent effects at cardiometabolic GWAS loci

et al. 2021

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Chromatin accessibility and gene expression in relevant cell contexts can guide identification of regulatory elements and mechanisms at genome-wide association study (GWAS) loci. To identify regulatory elements that display differential activity across adipocyte differentiation, we performed ATAC-seq and RNA-seq in a human cell model of preadipocytes and adipocytes at days 4 and 14 of differentiation. For comparison, we created a consensus map of ATAC-seq peaks in 11 human subcutaneous adipose tissue samples. We identified 58,387 context-dependent chromatin accessibility peaks and 3,090 context-dependent genes between all timepoint comparisons (log2 fold change>1, FDR<5%) with 15,919 adipocyte- and 18,244 preadipocyte-dependent peaks. Adipocyte-dependent peaks showed increased overlap (60.1%) with Roadmap Epigenomics adipocyte nuclei enhancers compared to preadipocyte-dependent peaks (11.5%). We linked context-dependent peaks to genes based on adipocyte promoter capture Hi-C data, overlap with adipose eQTL variants, and context-dependent gene expression. Of 16,167 context-dependent peaks linked to a gene, 5,145 were linked by two or more strategies to 1,670 genes. Among GWAS loci for cardiometabolic traits, adipocyte-dependent peaks, but not preadipocyte-dependent peaks, showed significant enrichment (LD score regression P<0.005) for waist-to-hip ratio and modest enrichment (P < 0.05) for HDL-cholesterol. We identified 659 peaks linked to 503 genes by two or more approaches and overlapping a GWAS signal, suggesting a regulatory mechanism at these loci. To identify variants that may alter chromatin accessibility between timepoints, we identified 582 variants in 454 context-dependent peaks that demonstrated allelic imbalance in accessibility (FDR<5%), of which 55 peaks also overlapped GWAS variants. At one GWAS locus for palmitoleic acid, rs603424 was located in an adipocyte-dependent peak linked to SCD and exhibited allelic differences in transcriptional activity in adipocytes (P = 0.003) but not preadipocytes (P = 0.09). These results demonstrate that context-dependent peaks and genes can guide discovery of regulatory variants at GWAS loci and aid identification of regulatory mechanisms.

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Association between risk factors of metabolic syndrome with lung function

Cited by 21 publications

References 34 publications

High-Density Lipoprotein Cholesterol: A Component of the Metabolic Syndrome with a New Role in Lung Function

High-Density Lipoprotein Cholesterol: A Component of the Metabolic Syndrome with a New Role in Lung Function

Association Between Metabolic Syndrome and Lung Function in Rural Areas in China

Chromatin accessibility and gene expression during adipocyte differentiation identify context-dependent effects at cardiometabolic GWAS loci

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