Association between resting heart rate just before starting the first dialysis session and mortality: A multicentre prospective cohort study

Inaguma, Daijo; Koide, Shigehisa; Takahashi, Kazuo; Hayashi, Hiroki; Hasegawa, Midori

doi:10.1111/nep.13048

Cited by 4 publications

(4 citation statements)

References 18 publications

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“…The initial time-point for the survival analysis was the date of baseline echocardiography (prescheduled routine echocardiography). Cox proportional hazards analyses were performed using ASA, AVCS, MVCS, and other echocardiographic and clinical variables, including parameters that are considered risk factors for the primary endpoint [2,23,[27][28][29][30][31][32][33]. Regarding the incidence of the primary endpoint, up to five variables that achieved P-values < 0.05 in the univariable analyses were available in the multivariable Cox proportional hazards analyses.…”

Section: Discussionmentioning

confidence: 99%

Impact of an angulated aorto-septal relationship on cardio-cerebrovascular outcomes in patients undergoing hemodialysis

Nakayama,

Yamamoto,

Ozeki

et al. 2024

PLoS ONE

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Aortic and valvular calcification are well-known risk factors for cardio-cerebrovascular events in patients undergoing hemodialysis. We investigated the clinical impact of an angulated aorto-septal angle as a result of aortic elongation due to aortic calcification on cardio-cerebrovascular outcomes in patients undergoing hemodialysis. We investigated 306 patients (mean age 65.4 years, 68% male) who underwent pre-scheduled routine echocardiography between April and September 2018. The angle between the anterior wall of the aorta and the ventricular septal surface (ASA) was quantified. We determined aortic and mitral valve calcification scores based on calcified cardiac changes; the aortic and mitral valve scores ranged between 0–9 and 0–6, respectively. The primary endpoint was a composite including cardio-cerebrovascular events and cardio-cerebrovascular death. The mean duration of dialysis among the patients in this analysis was 9.6 years. The primary endpoint was observed in 54 patients during the observational period (median 1095 days). Multivariable Cox proportional hazards analyses identified left ventricular ejection fraction (per 10% increase: hazard ratio [HR] 0.67; 95% confidential interval [CI] 0.53–0.84, P = 0.001), left ventricular mass index (per 10 g/m2 increase: HR 1.14; 95% CI 1.05–1.24, P = 0.001), ASA (per 10 degree increase: HR 0.69; 95% CI 0.54–0.88; P = 0.003), and aortic valve calcification score (HR 1.15; 95% CI 1.04–1.26, P = 0.005) as independent determinants of the primary endpoint. Kaplan-Meier analysis showed a higher incidence of the primary endpoint in patients with ASA <119.4 degrees than those with ASA ≥119.4 degrees (Log-rank P < 0.001). An angulated aorto-septal angle is an independent risk factor for cardio-cerebrovascular events and cardio-cerebrovascular death in patients undergoing hemodialysis.

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Section: Discussionmentioning

confidence: 99%

Impact of an angulated aorto-septal relationship on cardio-cerebrovascular outcomes in patients undergoing hemodialysis

Nakayama,

Yamamoto,

Ozeki

et al. 2024

PLoS ONE

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“…HR is associated with disease prognosis. Inaguma et al ( 29 ) reported that, in a multicenter prospective cohort study of 1,102 dialysis patients, resting HR before the first dialysis was found to be associated with all-cause mortality after starting dialysis. Patients with HR ≥ 101 bpm had significantly higher all-cause mortality than those with HR between 80 and 100 bpm, suggesting that HR may have a predictive value for disease regression.…”

Section: Discussionmentioning

confidence: 99%

Predictive Value of Heart Rate and Blood Pressure on the Prognosis of Postural Tachycardia Syndrome in Children

et al. 2022

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BackgroundTo investigate the predictive value of heart rate (HR) and blood pressure (BP) on the prognosis of postural tachycardia syndrome (POTS) in children.Materials and Methods53 cases of children aged 5 to 15 years who visited in the Pediatric Syncope Specialist Clinic of The Second Xiangya Hospital of Central South University for unexplained syncope or syncope precursor were diagnosed with POTS by head-up tilt test (HUTT) as the POTS group. 38 healthy children aged 5 to 16 years who underwent physical examination at the Child Health Care Clinic of the hospital in the same period were matched as controls (control group). The children with POTS were followed up after 3 months of treatment and were divided into good prognosis group (40 cases) and poor prognosis group (13 cases) according to the results of HUTT re-examination and whether the symptoms improved or not. HR and BP indicators were collected from each group at baseline and during HUTT.ResultsThere were 91 research subjects, of which 45 are males, with a mean age of 11.52 ± 2.13 years. (1) HR at 5 and 10 min (HR 5 and HR 10, respectively), HR difference at 5 and 10 min (HRD 5 and HRD 10, respectively), and HR and BP product at 5 and 10 min (RPP 5 and RPP 10, respectively) were greater in the POTS group than in the control group (P < 0.01). (2) HR 5, HR 10, HRD 5, HRD 10, and RPP 10 in children with POTS were smaller in the good prognosis group than the poor prognosis group (P < 0.01). (3) The area under curve was 0.925 on the four combined indicators (HR 5, HR 10, HRD 5, and HRD 10), predicting a good prognosis of POTS, sensitivity of 99.99%, and specificity of 75.00%.ConclusionsHR 5, HR 10, HRD 5, HRD 10, and RPP 10 and the four combined indicators (HR 5, HR 10, HRD 5, and HRD 10) had predictive value for the POTS prognosis in children. The predictive value of the four combined indicators for the POTS prognosis was better than that of the single HR 5, HRD 5, and RPP 10.

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“…A study of 1102 new HD patients found that those with a resting heart rate >100 beats/min before their initial dialysis (N = 69) had an adjusted all‐cause mortality rate 2.3‐fold higher than those with a heart rate of 80‐100 beats/min. Patients with heart failure, atrial fibrillation, beta blocker use, and other confounders were excluded from the study …”

mentioning

confidence: 99%

“…Patients with heart failure, atrial fibrillation, beta blocker use, and other confounders were excluded from the study. 6 Continuous cardiac rhythm monitoring using implant loop recorders was performed in 66 HD patients for up to 1 year. Clinically significant arrhythmias were detected 1678 times in 44 patients (most often bradycardia, <40 beats/min; N = 1461).…”

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confidence: 99%

Briefly Noted

Sherman¹

2018

Seminars in Dialysis

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Association between resting heart rate just before starting the first dialysis session and mortality: A multicentre prospective cohort study

Abstract: The resting heart rate just before starting the first dialysis session was associated with all-cause mortality after dialysis initiation.

Cited by 4 publications

References 18 publications

Impact of an angulated aorto-septal relationship on cardio-cerebrovascular outcomes in patients undergoing hemodialysis

Impact of an angulated aorto-septal relationship on cardio-cerebrovascular outcomes in patients undergoing hemodialysis

Predictive Value of Heart Rate and Blood Pressure on the Prognosis of Postural Tachycardia Syndrome in Children

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