Association Between Response Inhibition and Working Memory in Adult ADHD: A Link to Right Frontal Cortex Pathology?

Clark, Luke; Blackwell, Andrew D.; Aron, Adam R.; Turner, Danielle C.; Dowson, J. H.; Robbins, Trevor W.; Sahakian, Barbara J.

doi:10.1016/j.biopsych.2006.07.020

Cited by 159 publications

(108 citation statements)

References 54 publications

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“…Imaging studies have shown that a right-dominant network including the middle and inferior frontal gyri is linked to inhibitory control (Garavan et al, 1999;Aron et al, 2003) and to top-down control in a more general sense (Fassbender et al, 2006). Furthermore, several studies have associated insufficient functioning of the right hemisphere frontostriatal circuitry to inadequate response suppression in attention deficit hyperactivity disorder (Casey et al, 1997;Clark et al, 2007), and patient studies have linked right prefrontal lesions to deficits in sustained attention (Wilkins et al, 1987;Rueckert and Grafman, 1996). In the current study, further revealed that for both ROIs, mean signal changes were smaller during undistracted attention than during divided attention (p<0.001 in both cases).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Media multitasking is associated with distractibility and increased prefrontal activity in adolescents and young adults

et al. 2016

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Media multitasking is associated with distractibility and increased prefrontal activity in adolescents and young adults Moisala, M.; Salmela, V.; Hietajärvi, L.; Salo, E.; Carlson, S.; Salonen, O.; Lonka, K.; Hakkarainen, K.; Salmela-Aro, Katariina; Alho, K.Moisala, M., Salmela, V., Hietajärvi, L., Salo, E., Carlson, S., Salonen, O., . . . Alho, K. (2016). Media multitasking is associated with distractibility and increased prefrontal activity in adolescents and young adults. NeuroImage, 134, 113-121. doi:10.1016NeuroImage, 134, 113-121. doi:10. /j.neuroimage.2016 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT Conflict of interest statement:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.Keywords: media multitasking, attention, prefrontal cortex, fMRI A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPTPage 2

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Section: Accepted Manuscriptmentioning

confidence: 99%

Media multitasking is associated with distractibility and increased prefrontal activity in adolescents and young adults

et al. 2016

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“…For example, prior research shows evidence of a positive relation between ADHD and individual creativity (Abraham et al 2006;Shaw and Brown 1991;White and Shah 2006). The lower inhibitory control associated with ADHD (Barkley 1997;Clark et al 2007) has multiple behavioral consequences including a difficulty focusing attention on a given task, mind-wandering and a lower ability to distinguish irrelevant from relevant stimuli. Though this may hinder productivity in a formal work environment, in particular in terms of ''in-role performance'' (Halbesleben et al 2013), an ''uninhibited imagination'' has been found conducive to creative thinking (Carson et al 2003).…”

Section: Adhd-like Behavior and The Work Environmentmentioning

confidence: 99%

ADHD-like behavior and entrepreneurial intentions

et al. 2015

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Little is known about the relation between entrepreneurship and the extent of psychiatric symptoms. Validated psychiatric symptom scores are seldom used for non-clinical reasons. One prevalent symptom that deserves our interest is Attention Deficit and Hyperactivity Disorder (ADHD). ADHD is a developmental disorder characterized by inattentiveness and hyperactivity that has been linked to occupational choice and performance. Building on the person-environment fit literature, we hypothesize that individuals who exhibit behavior associated with ADHD are more likely to have entrepreneurial intentions. Using a sample of 10,104 students enrolled in higher education, we can confirm our prediction that students with a higher level of ADHD-like behavior are more likely to have entrepreneurial intentions. Additionally, we show that risk taking propensity is a mediator that partly explains this positive effect. Our study points to the importance of behavioral tendencies associated with developmental disorders, when making entrepreneurship decisions. Our study contributes to the literature on the determinants of entrepreneurship, which so far has largely neglected the effects of psychiatric symptoms on entrepreneurship.Electronic supplementary material The online version of this article

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“…Visual-spatial working memory has received relatively more attention in the literature. Several studies have documented visual-spatial working memory deficits in adults with ADHD (Clark et al, 2007;Dowson et al, 2004;McLean et al, 2004;Young, Morris, Toone, & Tyson, 2007), as well as deficits in sustained visual attention (Egeland, 2007). ADHD related visual-spatial working memory deficits tend to become more pronounced with increased task difficulty (Young et al, 2007) and may be associated with dysfunction in right prefrontal cortex brain regions (Clark et al, 2007).…”

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confidence: 99%

“…Several studies have documented visual-spatial working memory deficits in adults with ADHD (Clark et al, 2007;Dowson et al, 2004;McLean et al, 2004;Young, Morris, Toone, & Tyson, 2007), as well as deficits in sustained visual attention (Egeland, 2007). ADHD related visual-spatial working memory deficits tend to become more pronounced with increased task difficulty (Young et al, 2007) and may be associated with dysfunction in right prefrontal cortex brain regions (Clark et al, 2007). Although some researchers believe that spatial working memory impairments are secondary to the difficulties with inhibitory control that are often associated with ADHD (Ross, Harris, Olincy, & Radant, 2000), others view the spatial working memory deficit as a primary problem (Westerberg, Hirvikoski, Forssberg, & Klingberg, 2004).…”

mentioning

confidence: 99%

The effects of distraction and a brief intervention on auditory and visual-spatial working memory in college students with attention deficit hyperactivity disorder

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O'Keeffe

et al. 2012

Journal of Clinical and Experimental Neuropsychology

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Association Between Response Inhibition and Working Memory in Adult ADHD: A Link to Right Frontal Cortex Pathology?

Cited by 159 publications

References 54 publications

Media multitasking is associated with distractibility and increased prefrontal activity in adolescents and young adults

Media multitasking is associated with distractibility and increased prefrontal activity in adolescents and young adults

ADHD-like behavior and entrepreneurial intentions

The effects of distraction and a brief intervention on auditory and visual-spatial working memory in college students with attention deficit hyperactivity disorder

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