Association between respiratory diseases and molar-incisor hypomineralization: A systematic review and meta-analysis

Né, Yago Gecy de Sousa; Frazão, Déborah Ribeiro; Lopes, Géssica de Oliveira; Fagundes, Nathália Carolina Fernandes; Souza-Rodrigues, Renata Duarte de; Paula-Silva, Francisco Wanderley Garcia; Maia, Lucianne Cople; Lima, Rafael Rodrigues

doi:10.3389/fmed.2022.990421

Cited by 2 publications

(2 citation statements)

References 57 publications

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“…Molar hypomineralization (MH), commonly referred to as molar–incisor hypomineralization, is a DDE associated with a variety of environmental etiologies including childhood illnesses that occurs between birth and 3 years of age [ 81 , 82 , 83 ]. Maternal illness is associated with MH, indicating that prenatal stressors can play a role as well as perinatal and postnatal factors such as prematurity, caesarean section birth, kidney disease, urinary tract infection, and gastric disorders, to name a few [ 84 ].…”

Section: Environmental Etiologies Of Developmental Defects Of Enamelmentioning

confidence: 99%

Enamel Phenotypes: Genetic and Environmental Determinants

Wright

2023

Genes

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Dental enamel is a specialized tissue that has adapted over millions of years of evolution to enhance the survival of a variety of species. In humans, enamel evolved to form the exterior protective layer for the crown of the exposed tooth crown. Its unique composition, structure, physical properties and attachment to the underlying dentin tissue allow it to be a resilient, although not self-repairing, tissue. The process of enamel formation, known as amelogenesis, involves epithelial-derived cells called ameloblasts that secrete a unique extracellular matrix that influences the structure of the mineralizing enamel crystallites. There are over 115 known genetic conditions affecting amelogenesis that are associated with enamel phenotypes characterized by either a reduction of enamel amount and or mineralization. Amelogenesis involves many processes that are sensitive to perturbation and can be altered by numerous environmental stressors. Genetics, epigenetics, and environment factors can influence enamel formation and play a role in resistance/risk for developmental defects and the complex disease, dental caries. Understanding why and how enamel is affected and the enamel phenotypes seen clinically support diagnostics, prognosis prediction, and the selection of treatment approaches that are appropriate for the specific tissue defects (e.g., deficient amount, decreased mineral, reduced insulation and hypersensitivity). The current level of knowledge regarding the heritable enamel defects is sufficient to develop a new classification system and consensus nosology that effectively communicate the mode of inheritance, molecular defect/pathway, and the functional aberration and resulting enamel phenotype.

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Section: Environmental Etiologies Of Developmental Defects Of Enamelmentioning

confidence: 99%

Enamel Phenotypes: Genetic and Environmental Determinants

Wright

2023

Genes

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“…MIH was also found to be associated with postnatal medical conditions, such as high fever [13], respiratory illness (bronchitis or asthma) in the first 4 years of life [14][15][16][17], otitis media [18,19], and chickenpox [20,21].…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of Developmental Enamel Defects in Israeli Children and Its Association with Perinatal Conditions: A Cross-Sectional Study

et al. 2023

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Molar incisor hypomineralization (MIH) and deciduous molar hypomineralization (DMH) affect the first permanent molars and second primary molars, respectively, causing a greater dental treatment burden and worse oral health quality of life among affected children. We assessed the prevalence and risk factors of MIH and DMH among 1209 children aged 3–13 years who attended a university dental clinic in Israel in 2019–2020. Clinical examinations were conducted to assess the presence of DMH and MIH. Potential etiological factors of MIH and DMH, including demographics, the mother’s perinatal health, and the child’s medical history during the first three years of life, were retrieved using a questionnaire. To examine the associations between the demographic and clinical variables and the prevalence of MIH and DMH, continuous variables were tested using the Kruskal–Wallis test with Bonferroni corrections. Categorical variables were analyzed by chi-squared test. Multivariate logistic regression was conducted to evaluate which of the significant variables found in the univariate analysis could predict a diagnosis of both MIH and DMH. The prevalence of MIH and DMH was 10.3% and 6.0%, respectively. Age ≥5 years, taking medications during pregnancy and severe lesions were associated with a greater risk for a diagnosis of DMH + MIH. Multivariate logistic regression with adjustment for age showed that the severity of hypomineralization was positively and significantly associated with a diagnosis of MIH + DMH with an odds ratio of 4.18 (95% confidence interval 1.26–17.16), p = 0.03. MIH should be diagnosed and monitored in young children to prevent further deterioration. Moreover, a preventive and restorative program for MIH should be established.

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Association between respiratory diseases and molar-incisor hypomineralization: A systematic review and meta-analysis

Cited by 2 publications

References 57 publications

Enamel Phenotypes: Genetic and Environmental Determinants

Enamel Phenotypes: Genetic and Environmental Determinants

The Prevalence of Developmental Enamel Defects in Israeli Children and Its Association with Perinatal Conditions: A Cross-Sectional Study

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