Association between renin–angiotensin–aldosterone system-related genes and blood pressure in a Korean population

Abstract

AIMS. Blood pressure control is influenced by various genetic and environmental factors, and genetic susceptibility is important in the development of essential hypertension. Because the renin-angiotensin-aldosterone system (RAAS) has a key role in vasoconstriction, vasodilation, and sodium and electrolyte balance, it is central in blood pressure control and so is an appropriate target in hypertension treatments. The present study assessed the association of RAAS-related genes with blood pressure and hypertension in a Korean population. Single nucleotide polymorphisms (SNPs, n = 114) in nine RAAS-related genes (AGT, REN, ACE, ACE2, AGTR1, CYP11B2, NR3C2, MAS1, and CMA1) were assessed for their correlation with blood pressure and hypertension using genotype data of 8842 individuals from the Korea Association Resource subject pool. MAJOR FINDINGS. Linear regression analysis revealed a statistically significant association with blood pressure of 10 SNPs in six genes (ACE, ACE2, CYP11B2, NR3C2, MAS1, and CMA1). An additional hypertension case-control study identified 10 SNPs in NR3C2 and ACE that were linked to hypertension. PRINCIPAL CONCLUSION. Three SNPs (rs11737660, rs6810951, and rs10519963) in NR3C2 correlate with both blood pressure and hypertension. Genetic polymorphisms in RAAS-related genes appear to be associated with hypertension in a Korean population.

Association Analysis of Reactive Oxygen Species-Hypertension Genes Discovered by Literature Mining

“…The most frequent gene was AGT (angiotensinogen [serpin peptidase inhibitor, clade A, member 8]), which was reported on 320 ROS-hypertension articles, but it was not associated with hypertension in this study or our previous report [22]. Most of the genes that were published in more than 40 articles were not associated with hypertension or showed weak associations; 6 of 17 genes were significant, and the lowest p-value was 0.014 (nitric oxide synthase 1 [neuronal], NOS1 ).…”

Gene-Gene Interactions in Renin-Angiotensin-Aldosterone System Contributes to End-Stage Renal Disease Susceptibility in a Han Chinese Population

“…Several studies recently identified RAAS gene mutations and polymorphisms that affected host susceptibility to several diseases, including hypertension [7], type 2 diabetes [8], myocardial infarction [9], chronic kidney disease [6, 10], and ESRD [11]. Some studies also indicated that RAAS gene single nucleotide polymorphisms (SNPs) could alter homeostasis to an abnormal state [12, 13].…”

Is the role of the angiotensin-converting enzyme gene in Alzheimer's disease independent of hypertension?

“…Although hypertension itself has a multifactorial pathogenesis [29] , ACE, as part of the RAAS system, has shown the strongest association with hypertension after adjusting for age, sex, and weight in a genome-wide association study that was conducted in Korea and other countries [30,31] . A recent genome-wide association study investigating ACE2 polymorphisms among Chinese and Caucasian participants has reported significant associations in women with hypertension or increased diastolic blood pressure [32] .…”