Association between Renal Function Tests and Pentachlorophenol Exposure

Abstract

Data are presented and renal function tests and Pcp measurements on consecutive blood and urine samples collected from 18 workers at a wood treatment plant before, during, and after a 20-day vacation. Pcp concentrations in blood averaging 5.1 ppm before vacation fell to 2.2 ppm during vacation but with a temporary rise early in this nonexposure period, suggesting a body tissues store of Pcp which was mobilized in response to a negative Pcp balance. Urine Pcp concentrations showed similar but less marked variations. Creatinine clearance and phosphorus reabsorption values were depressed before vacation but showed significant improvement during vacation, suggesting that Pcp exposure reduced both glomerular filtration rate and tubular function, with recovery following a nonexposure period.

Effect of Pentachlorophenol (PCP) on Frog Cornea Epithelium

“…A slight negative hydrostatic pressure was applied to the lower chamber to help secure the cornea to the copper grid. Control (regular) solutions contained (in mM) (stroma): Na + , 102; K + , 4.0; Ca 2+ , 1; Mg 2+ , 0.8; Cl − , 106.2; SO 4 2− , 0.8; phosphate, 1; and glucose, 10; (tear): Na + , 100; K + , 4; Ca 2+ , 1; Cl − , 97; HCO 3 − , 5; phosphate, 1; and glucose, 10. K + was substituted for Na + in high K + solutions.…”

Toxicology of Fungicides

“…Short-term respiratory exposure may result in transient mild liver dysfunction (increased bilirubin, serum glutamatepyruvate and oxaloacetic-pyruvate transaminases, and -glutamyl transferase) with abnormal porphyrin metabolism (increased uroporphyrin and -aminolevulinic acid) (Fielder et al, 1982;Jirasek et al, 1974;Kozak et al, 1979). Reversible renal function changes (decreased creatinine clearance and phosphaturia) have been described (Begley et al, 1977). There are no clinical indications of peripheral neuropathy, although exposed workers have been shown to have decreased sensory nerve conduction rates (Triebig et al, 1981).…”

A Morbidity Study of Former Pentachlorophenol-Production Workers

“…The chronic effects of exposure to PCP have been studied in PCP production workers (4-10), PCP formulators (11), wood treatment workers (12,13), sprayers (11), and sawmill workers (14)(15)(16). Several studies have demonstrated that exposure to commercial PCP can produce chloracne (4,8-10,17,18).…”