“…To improve the accuracy of the results, compared to the MR-Egger method, we performed complementary analyses using the weighted median method and the simple mode and weighted mode. To detect and correct horizontal pleiotropy by removing outliers, we used the Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO) test 12 . Statistical analysis was performed using R (version 4.3.1) and R packages (TwoSampleMR and MR-PRESSO).…”