Association between regional longitudinal strain and left ventricular thrombus formation following acute myocardial infarction

Olsen, Flemming Javier; Pedersen, Sune; Galatius, Søren; Fritz‐Hansen, Thomas; Gislason, Gunnar

doi:10.1007/s10554-020-01825-5

Cited by 15 publications

(10 citation statements)

References 20 publications

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“…material). The studies were published between 2002 and 2021, including three cohort studies [8-10] and sixteen case-control studies [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. There were ten studies from Asian countries such as China, Japan, Turkey, and Saudi Arabia, five from European countries such as the UK and Denmark, three from North America, and one from Australia.…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

Incidence and Risk Factors of Left Ventricular Thrombus in Acute ST-Segment Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention: A Meta-Analysis

Wang

Yan

et al. 2022

Med Princ Pract

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Objective: Left ventricular thrombosis (LVT) is a common complication of acute ST-segment elevation myocardial infarction (STEMI). This study attempted to synthesize the available evidence to understand the incidence and risk factors of LVT in acute STEMI patients undergoing primary percutaneous coronary intervention (PCI). Methods: We searched PubMed, Embase, Cochrane Library, and Web of Science for studies published from January 2001 to January 2022. The random-effects and fixed-effects model meta-analysis estimated pooled incidence, mean difference (MD), odds ratio (OR), and 95% confidence interval (CI). Review Manager 5.4 software was used for meta-analysis performance. Results: The results of meta- analysis showed that the incidence of LVT in acute STEMI treated by primary PCI was 4% [95% CI (0.03, 0.05)], and the overall pooled incidence in patients with anterior STEMI was 10.0% [95% CI (0.07, 0.12)]. Anterior STEMI [OR =11.93, 95%CI (6.25,22.78), p =0.0003.], left anterior descending-related infarct [OR =6.85, 95%CI (3.70,12.66), p< 0.00001.], left ventricular wall motion abnormalities [OR =7.53, 95%CI (3.18,17.82), p< 0.00001.], and lower post-PCI LVEF [MD = 13.78, 95%CI (12.15, 15.41), p< 0.00001.] were risk factors for post-PCI LVT. Conclusion: The incidence of LVT after acute STEMI in the PCI era remains high. This study provides a preliminary overview of STEMI patients at risk for post-PCI LVT and will help the design of prospective randomized controlled trials(RCTs) for the management and prevention of LVT.

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Section: Study Selection and Characteristicsmentioning

confidence: 99%

Incidence and Risk Factors of Left Ventricular Thrombus in Acute ST-Segment Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention: A Meta-Analysis

Wang

Yan

et al. 2022

Med Princ Pract

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“…1. A total of 23 studies met the inclusion criteria after screening 1491 potentially relevant studies [5–9,14–31].…”

Section: Resultsmentioning

confidence: 99%

“…The description of the study design, number of participants, participant characteristics and patient inclusion criteria in the included studies are shown in Table 1. There were 4 prospective cohort studies [7,14,16,21], 10 retrospective cohort studies [5,17,19,20,22,24,26,28,30,31], 2 cross-sectional studies [9,15], 3 case–control studies [6,8,25] and 4 post-hoc analyses of existing studies [18,23,27,29]. These studies took place in the USA, China, Turkey, Australia, Germany, Denmark, Saudi Arabia and the UK between 2000 and 2019.…”

Section: Resultsmentioning

confidence: 99%

Predictors of left ventricular thrombus after acute myocardial infarction: a systematic review and meta-analysis

Kwok

Bennett

Borovac

et al. 2023

Coronary Artery Disease

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Left ventricular thrombus (LVT) is a recognized complication of acute myocardial infarction (AMI) which can cause significant morbidity and mortality from systemic embolism. We conducted a systematic review and meta-analysis of factors that have been shown in studies to be independently predictive of LVT post-AMI. A total of 23 studies met the inclusion criteria with 1 047 785 patients. The proportion of patients with LVT ranged from 0.2% in the nationwide study in the USA to 36.1% in the cohort of patients with LV aneurysm. Pooled results from nine studies suggest that greater values for left ventricular ejection fraction is associated with reduced odds of LVT formation [odds ratio (OR) 0.90; 95% confidence interval (CI), 0.86–0.93; I2 = 76%]. Left ventricular aneurysm was a significant predictor of LVT formation (OR 6.07; 95% CI, 2.27–16.19; I2 = 91%; seven studies) and anterior location of MI was also a significant predictor (OR 7.72; 95% CI, 2.41–24.74; I2 = 69%; four studies). Three studies suggest that there was an increase in odds of LVT formation with greater values of C-reactive protein (OR 2.06; 95% CI, 1.07–3.97; I2 = 89%; three studies). The use of glycoprotein IIb/IIIa inhibitors (OR 2.52; 95% CI, 1.55–4.10; I2 = 0%; two studies) and greater SYNTAX score (OR 1.21; 95% CI, 1.08–1.36; I2 = 46%; two studies) were associated with LVT. In conclusion, patients with reduced ejection fraction, AMI and with left ventricular aneurysm are at risk of LVT formation and careful imaging evaluation should be performed to identify LVT in these patients to prevent stroke or peripheral embolism.

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“…The regional strain analysis is also important in cardiac function assessment, especially in regional motion. Recent studies (29,30) have indicated that regional circumferential and longitudinal strain impairment in patients with myocardial infarction could help in differentiating between damaged and normal myocardium. Another study (7) reported that subclinical LV dysfunction was correlated to the impaired regional strain for the lateral wall in myocarditis with a normal EF.…”

Section: Discussionmentioning

confidence: 99%

Feasibility of one breath-hold cardiovascular magnetic resonance compressed sensing cine for left ventricular strain analysis

Chen

Pan²,

Hu³

et al. 2022

Front. Cardiovasc. Med.

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ObjectiveTo investigate the feasibility of 3D left ventricular global and regional strain by using one breath-hold (BH) compressed sensing cine (CSC) protocol and determine the agreement between CSC and conventional cine (CC) protocols.MethodsA total of 30 volunteers were enrolled in this study. Cardiovascular magnetic resonance (CMR) images were acquired using a 1.436 T magnetic resonance imaging (MRI) system. The CSC protocols included one BH CSC and the shortest BH CSC protocols with different parameters and were only performed in short-axis (SA) view following CC protocols. Left ventricular (LV) end-diastole volume (EDV), end-systole volume (ESV), stroke volume (SV), and ejection fraction (EF) global and regional strain were calculated by CC, one BH CSC, and shortest BH CSC protocols. The intraclass correlation coefficient (ICC) and coefficient of variance (CV) of these parameters were used to determine the agreement between different acquisitions.ResultsThe agreement of all volumetric variables and EF between the CC protocol and one BH CSC protocol was excellent (ICC > 0.9). EDV, ESV, and SV between CC and shortest BH CSC protocols also had a remarkable coherence (ICC > 0.9). The agreement of 3D LV global strain assessment between CC protocol and one BH CSC protocol was good (ICC > 0.8). Most CVs of variables were also good (CV < 15%). ICCs of all variables were lower than 0.8. CVs of all parameters were higher than 15% except global longitudinal strain (GLS) between CC and shortest BH CSC protocols. The agreement of regional strain between CC and BH CSC protocols was heterogeneous (-0.2 < ICC < 0.7). Many variables of CVs were poor.ConclusionNotably, one BH CSC protocol can be used for 3D global strain analysis, along with a good correlation with the CC protocol. The regional strain should continue to be computed by the CC protocol due to poor agreement and a remarkable variation between the protocols. The shortest BH CSC protocol was insufficient to replace the CC protocol for 3D global and regional strain.

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Association between regional longitudinal strain and left ventricular thrombus formation following acute myocardial infarction

Cited by 15 publications

References 20 publications

Incidence and Risk Factors of Left Ventricular Thrombus in Acute ST-Segment Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention: A Meta-Analysis

Incidence and Risk Factors of Left Ventricular Thrombus in Acute ST-Segment Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention: A Meta-Analysis

Predictors of left ventricular thrombus after acute myocardial infarction: a systematic review and meta-analysis

Feasibility of one breath-hold cardiovascular magnetic resonance compressed sensing cine for left ventricular strain analysis

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